Abstract:
Chemical exchange saturation transfer (CEST) imaging is an important molecular MRI technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. Applications of CEST or more specially protein-based amide proton transfer (APT) imaging in identifying molecular markers in gliomas has been explored in recent years. In this paper, after briefing the basic principles and quantification methods of CEST imaging, I review its early applications in identifying IDH mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we will discuss the limitations or weaknesses in these studies.
Audience Take Away Notes:
- Learn the novel CEST imaging technique
- Researchers could expand their research and explore new applications on all fronts
- Radiologists could enhance their daily clinical practice
