The purpose of this historical review is to trace the application of radiopharmaceuticals for diagnosis of tumors and treatment of cancer in the past half a century in Japan. Positron Emission Tomography?PET?using 18F labelled fluorodeoxyglucose (a radioactive glucose analog) has [....] » Read More
Despite aggressive therapy consisting of surgery followed by radio/chemotherapy Glioblastoma (GBM) recurs in almost all patients and, currently, there are no proven therapies to treat recurrent GBM (rGBM). Recent developments in nanomedicine provide new and promising opportunitie [....] » Read More
Hepatocellular carcinoma (HCC) is one of the most lethal cancers for humans. MAN2A1-FER is one of the most frequent oncogenic fusion genes in the HCC. In this report, we showed that MAN2A1-FER ectopically phosphorylated the extracellular domains of PDGFRA, MET, AXL, and N-cadheri [....] » Read More
Amide proton transfer (APT) imaging is a novel protein-based molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. APT imaging is a specific type of chemical exchange saturation transfer imaging. Theoretically, the APT-MRI signal d [....] » Read More
In this presentation the a case report will be presented focusing on the effects of mild hyperbaric oxygen therapy (mHBOT) in a patient with a severe pain symptomatology due to the sequelae of a radiotherapy cycle for prostate adenocarcinoma. A physiological discussion on the bio [....] » Read More
Gastrointestinal metastases of lung cancer are relatively uncommon, yet occur at a higher frequency than would be expected among patients that exhibit a longer survival interval. Metastases that arise in the small intestines are often associated with no or few symptoms such that [....] » Read More
Introduction: Lubumbashi is the 2nd city in the DRC, 2,812,000 inhabitants (2023). Its pediatric oncology unit (CUL) works in collaboration with ophthalmologists, pathologists, surgeons, imagers, etc…(RCP). Financially supported by several NGOs including AMCC, GFAOP&h [....] » Read More
Introduction: In hematolymphoid malignancies a proper evaluation of bone marrow smears is important to assess post-chemotherapy related changes in bone marrow. Morphological examination holds importance in differentiating between marrow in remission vs minimal residual disease. I [....] » Read More
We present three cases of benign pediatric tumors in which there was significant diagnostic dilemma. We share our experience how a pre-sacral dermoid cyst gave rise to bowel bladder obstruction and subsequent incontinence, a retroperitoneum teratoma just superior to left kidney m [....] » Read More
Epigenetics' role in non-small cell lung cancer (NSCLC) and coronary artery disease (CAD) is currently emerging as a crucial player at several levels, ranging from pathophysiology to treatments. We aim to determine the combination of certain regular epigenetic controls that d [....] » Read More
Introduction: Squamous cell carcinoma of the buccal mucosa is the most common oral cavity cancer in Southeast Asia. In India, 60 to 80% of oral squamous cell carcinoma cases present with advanced stage as compared to 40% in developed countries. Carcinoma of the buccal mucosa is t [....] » Read More
Breast cancer is the second leading cause of mortality and fatal disease among women, making it a serious public health issue at present. Timely diagnosis plays a pivotal role in improving prognosis and survival rates, underscoring the urgency for early detection. Fortunately, ad [....] » Read More
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with worst prognosis. Cytotoxic chemotherapy is the mainstay of treatment for the advanced stage disease. However, response rates to these agents are limited and many responders eventually become [....] » Read More
Objective: I aimed to investigate the potential immunomodulatory role of complex Autophagy, Toll-like Receptors and PI3-Akt signaling networks/cross-talks in single cell immunobiology by targeting circulating tumor cells in benign prostate hyperplasia and prostate cancer for even [....] » Read More
Chemical exchange saturation transfer (CEST) imaging is an important molecular MRI technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. Applications of CEST or more specially protein-based amid [....] » Read More
Introduction: The rationale for combination therapy in treating cancer is to use drugs with different mechanisms of action, thereby reducing the likelihood that resistant cancer cells will develop. CLX-155A is an oral prodrug conjugate hydrolyzed by intestinal enzymes to yield 5& [....] » Read More
Introduction: The rationale for combination therapy in treating cancer is to use drugs with different mechanisms of action. This approach reduces the likelihood that resistant cancer cells will develop. CLX-155A is an oral prodrug conjugate hydrolyzed by intestinal enzymes to yie [....] » Read More
Recently, we have discovered the small-molecule degraders of ubiquitin-like modifier 1 (SUMO1) that has been considered as undruggable oncoprotein. The degrader compounds degrade SUMO1 oncoprotein through activation of Cullin-1 E3 ligase-mediated ubiquitination of the protein in [....] » Read More
The term posterior reversible encephalopathy syndrome (PRES) refers to an acute syndrome characterised by a range of neurological symptoms and posterior transient changes on neuroimaging. Common clinical presentation includes headache, confusion, visual disturbances, seizures, an [....] » Read More
Follicular dendritic cell sarcoma (FDCS) is a rare type of sarcoma that originates from the stromal component of the germinal center of the B-follicle. Its presentation and prognosis vary, as it can be nodal or extranodal, localized or multifocal, and can be fatal in 20% of cases [....] » Read More
Introduction: The effects of oncological treatments on emotional well-being can negatively impact sexual health and intimate relationships. Improvements in cancer management have prolonged patient survival, highlighting the importance of addressing sexual health following diagnos [....] » Read More
Introduction: The American Cancer Society (ACS) has established guidelines to improve the quality of life and survival of cancer survivors. Adherence to these recommendations is low internationally, and there is no available data in Uruguay. Objective: To determine the proport [....] » Read More
Chromatin bridges are strings of chromatin connecting the anaphase poles or daughter nuclei and have been linked to tumourigenesis. Chromatin bridges can arise from segregation of interlinked chromosomes after improper resolution of double strand DNA catenates, or from dicentric [....] » Read More
Extracellular vesicle (EV)-based communication is an evolutionarily conserved mechanism of intercellular communication, from bacteria to humans. Eukaryotic EVs are nanosized particles of endosomal origin that carry and deliver to target cells complex cargo including DNA, RNA, pro [....] » Read More
Introduction: During the early stages of the COVID-19 pandemic, Multiple Myeloma (MM) patients exhibited a high hospitalization rate (56%), with 20% requiring critical care and an 18% increased mortality risk. MM patients undergoing anticancer therapy who contracted symptomatic C [....] » Read More
According to the Barcelona Clinic Liver Cancer (BCLC) staging system, only the advanced stage (stage C) hepatocellular carcinoma (HCC) patient is eligible for systemic treatments. In addition to tyrosine kinase inhibitors, multikinase inhibitors and anti-vascular-endothelial gr [....] » Read More
Introduction: Lung cancer is primarily considered a disease of older adults with a history of smoking; however, there is a growing recognition of lung cancer occurring in younger, non-smoking individuals. A subset of these patients presents with driver mutations, such as anaplast [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. If unresolved, chromatin bridges can break in cytokinesis leading to micronuclei formation and accumulation of DNA damage. To prevent this, human cells form accumulation [....] » Read More
The extracellular matrix (ECM) plays an important role in the progression of cancer. Collagen is the most abundant component in ECM, and is involved in the biological formation of cancer. Although type XI collagen is a minor fibrillar collagen, collagen XI alpha 1 chain (COL11A1) [....] » Read More
An 88-year-old male patient was referred to our hospital for unexplained anemia, Gastric fiberscope revealed gastric cancer. No metastasis was suspected on admission. However, his anemia sustained in spite of the treatment with blood transfusion and iron supplement. His LDH level [....] » Read More
Introduction: Up until recently, it was thought that cancer may strike without warning. Now, however, we know that each type of cancer has a specific cause, so let's see whether we can treat them all separately. We can now pinpoint the causes of every type of cancer as well a [....] » Read More
Aims and Objectives: The study evaluated the psycho-oncology parameters, including denial, anger, bargaining, depression, acceptance, and bereavement (nick-named DABDAB) and others. This study investigated whether or not there is a need to employ (full-time or visiting) psycho-on [....] » Read More
Introduction: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver that typically arises in the context of chronic liver disease and cirrhosis. Biochemical markers such as alpha-fetoprotein (AFP) and liver function tests (LFTs) are often used to aid diagnosis. [....] » Read More
Nanomedicines are promising strategies for anticancer therapy; however, camouflaging nanomedicines with cell based carrier i.e. RBC/Platelet membrane would significantly prolong its retention time in the bloodstream, enhance the targeting ability and reduce the off-target effects [....] » Read More
Psycho oncology is an interdisciplinary field at the intersection of psychology and oncology, focusing on the psychological, social, behavioral and ethical aspects of cancer. Psycho oncology plays a vital role in the comprehensive care of cancer patients, encompassing psychologic [....] » Read More
Introduction: The tobacco epidemic is a major public health threat, causing over 8 million deaths annually, including 1.2 million from second-hand smoke. Death from cancer is twice as high among smokers in comparison to nonsmokers, with having four times greater risk of death fro [....] » Read More
Advancements in artificial intelligence (AI) are revolutionizing various sectors and rapidly reshaping cancer research and personalized clinical care. The combination of big data and powerful computing capacity has unlocked the transformative potential of AI-based approaches, par [....] » Read More
Most cancer-related deaths are caused by metastases, yet the mechanisms that promote metastatic dissemination are not fully defined. To identify mutational drivers of metastasis in skin cancer, we analyzed 41 metastatic cutaneous squamous cell carcinomas (cSCC) and patient-matche [....] » Read More
Background: Hemi-maxillectomy, the surgical removal of part of the maxilla, often results in significant defects that affect speech, mastication, and aesthetics. These defects can lead to nasal regurgitation, impaired speech, and psychological distress. Objective: Th [....] » Read More
Background: Placement of self-expandable metal stents (SEMS) by endoscopy has become a recommend treatment for esophagojejunal anastomotisis leakage (EJAL). There is no clear conclusion on whether neoadjuvant therapy will increase the incidence of EJAL in adenocarcinoma of the ga [....] » Read More
Backgroud: Ovarian cancer is the most malignant gynecological tumor, although maintenance therapy with poly (ADP?ribose) polymerase inhibitor (PARPi) has improved patient outcomes, PARPi resistance remains a major challenge in clinical practice. Therefore, there is an urgent need [....] » Read More
Diseases and molecular targets considered undruggable, particularly those hidden within the tumor microenvironment (TME), remain challenging for existing therapeutic approaches. In such cases RNA interference (RNAi) therapeutics, such as small interfering RNA (siRNA) present a po [....] » Read More
Background: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is known for its aggressiveness, early metastasis, and poor prognosis. Despite advancements in diagnostic techniques and treatments, the survival rate remains low. Understanding metabolic reprogr [....] » Read More
Title : Genomic instability analysis in DNA from papanicolaou test provides a new avenue for early diagnosis of high-grade serous ovarian cancer
Sergio Marchini, Humanitas Research Hospital, Italy
Epithelial ovarian cancer (EOC) is the 5th cancer-related cause of death among women worldwide. EOC is usually diagnosed at an advanced stage when tumour cells have already spread throughout the pelvis in the peritoneal cavity. Five-year survival rate is around 30% in patients wi [....] » Read More
Title : Micro-Invasive solid papillary carcinoma of the nipple: A case study
Shinya Tajima, National Hospital Organization, Shizuoka Medical Centre, Japan
Herein, we would like to present the case of about 80-year-old female. Her chief complaint was bloody nipple discharge in the left breast. She came to our hospital for thorough examination and treatment. Ultrasonography detected intraductal carcinoma of about 10mm spreading. The [....] » Read More
Title : Multiple endocrine neoplasia and sporadic insulinomas
Klaus Brusgaard, Odense University Hospital, Denmark
Functional pancreatic neuroendocrine tumors (PNETs) may be hereditary or sporadic. Hereditary forms are often caused by MEN1 mutations. The majority of insulinomas are sporadic, solitary and low-grade. The tumorigenesis in sporadic insulinomas is not well described. We describe t [....] » Read More
Title : Multiplexed detection of biomarkers for early-stage ovarian cancer
Michael Thompson, University of Toronto, Canada
Ovarian cancer(OC) results in some 150,000 deaths worldwide of nearly 300,000 new cases each year. Unfortunately, only 20% of patients are diagnosed at the early stages (I and II) of the disease when treatment is most effective, leading to a 5-year relative survival rate of only [....] » Read More
Title : MYC expression is an adverse prognostic factor ALK+ anaplastic large cell lymphoma
Jie Xu, The University of Texas MD Anderson Cancer Center, United States
The role of MYC dysregulation has been studied extensively in B cell lymphomas, but little is known about its significance in T cell lymphomas. This study, for the first time in the literature, assessed the clinicopathologic and prognostic significance of MYC expression in [....] » Read More
Title : ColoNode analysis of colorectal cancer lymph nodes - An improved method for assessment of tumor stage and prognosis
Marie Louise Hammarstrom, Umea University, Sweden
Colorectal cancer is globally one of the most prevalent cancers and a common cause of cancer-related mortality. The curative treatment is surgery. Unfortunately, recurrence is common with approximately 25% of the patients having relapse. Lymph node (LN) metastasis is the single m [....] » Read More
Title : Genomic analyses of circulating cell free DNA in follicular lymphoma: Diagnostic prognostic and therapeutic implications
Can Kucuk , Dokuz Eylul University, Turkey
In this talk, the potential of cfDNA genotyping on diagnosis and prognostication of follicular lymphoma (FL) will be presented. As a frequent non-Hodgkin lymphoma type, FL is generally indolent with a variable clinic presentation including asymptomatic as well as symptomati [....] » Read More
Title : Innate lymphoid cells and cancer: A new frontier in immunology
Giuseppe Ercolano, University of Naples Federico II, Italy
Innate lymphoid cells (ILCs) have emerged as pivotal players in the immune system, with their roles extending far beyond traditional innate immunity. Recent advances in immunology have highlighted the significant influence of ILCs on tumor development, progression, and response t [....] » Read More
Title : Towards a home companion diagnostic test for the early detection of breast cancer
Nur Aimi Aliah Zainurin, Aberystwyth University, United Kingdom
Breast cancer is one of the deadliest cancers with 685,000 deaths and 2.26 million cases reported in 2020. Early detection is crucial for better treatment outcome. Mammography is the gold standard screening modality for breast cancer diagnosis but use of a cost-effective companio [....] » Read More
Title : Proposal for new diagnostic criteria for sarcopenia based on CT Imaging in Saudi population: A novel method in oncology research
Zahra Husain, Eastern Health Cluster, Saudi Arabia
Background: Sarcopenia has been shown to be an independent predictor of lower overall survival in oncology patients. Several studies have used computed tomography (CT) to measure psoas muscle surface area to define sarcopenia. However, the cut-off values based on CT imaging remai [....] » Read More
Title : New paradigm shift towards pancreatic cancer enabling nano- based biosensors for detection of exosomes
Tanvi Gupta, National Cheng Kung University, Taiwan
Pancreatic cancer shows high mortality rate with poor prognosis and is expected to be the major cause of cancer deaths by 2030. Due to its aggressive nature for growth and progression, it usually goes unnoticed at an early stage due to lack of symptoms and by the time diagnosis a [....] » Read More
Title : Melanoma with brain metastasis
Maria Zahra, Cardiff and Vale NHS trust hospital, United Kingdom
Melanoma metastasis to brain. A case related to the presentation of a patient who presented with seizures and CT head revealed space occupying lesion. This patient had a background of Melanoma for which he had a biopsy done and he was waiting the results. Audience Take Away No [....] » Read More
Title : Introducing CancerHubs: A systematic data mining and elaboration approach for identifying novel cancer related protein interaction hubs
Nicola Manfrini, University of Milan, Italy
Introduction: Discovering the players and understanding the molecular mechanisms involved in cancer initiation and progression are fundamental issues for developing effective diagnostic tools and targeted therapies. Traditional methods for predicting protein involvement in cancer [....] » Read More
Title : Implementation of Enhanced Recovery After Surgery (ERAS) protocols in cancer surgery: A case report
Amrita Anand Dhar, Leicester Royal Infirmary, United Kingdom
Introduction: Enhanced Recovery After Surgery (ERAS) protocols represent a paradigm shift in perioperative care, focusing on evidence-based practices to reduce surgical stress, optimize pain management, and accelerate postoperative recovery. Initially developed for colorectal sur [....] » Read More
Title : Vacuum assisted breast biopsy: What can we do during an active bleeding and vasovagal syncope in order to complete the procedure?
Ivelis M Sarachi, Centro Diagnostico Mon, Argentina
Vacuum Assisted Breast Biopsy (VABB) is a minimally invasive procedure in which a suspicious breast sample (BS) is removed with a vacuum pump through a small skin incision under local anesthesia. Can be performed under mammography (M), US or MRI guidance. Our topic is the VABB M [....] » Read More
Title : Noninvasive nondestructive comparison of pigmented and nonpigmented melanomas using vibrational optical coherence tomography
Frederick H Silver, Robert Wood Johnson Medical School, Rutgers University, United States
We have developed a new noninvasive technique termed vibrational optical coherence tomography (VOCT) to optically image and measure the resonant frequency of cellular, blood vessel, papillary collagen, and fibrotic tissue in the skin. Preliminary results on normal skin indicate t [....] » Read More
Title : Targeted immunotherapy to inhibit circadian-disruption induced aggressive tumorigenesis
Tapasree Roy Sarkar, Texas A&M University, United States
Background: Epidemiological studies have shown that circadian rhythm disruption (CRD) is associated with the risk of breast cancer. However, the role of CRD in mammary gland morphology and aggressive basal mammary tumorigenesis and the molecular mechanisms underlying CRD and canc [....] » Read More
Title : ATAD2 is a driver and a therapeutic target in ovarian cancer that functions by upregulating CENPE
Romi Gupta, The University of Alabama at Birmingham, United States
Ovarian cancer is a complex disease associated with multiple genetic and epigenetic alterations. The emergence of treatment resistance in most patients causes ovarian cancer to become incurable, and novel therapies remain necessary. We identified epigenetic regulator ATPase famil [....] » Read More
Title : An attention based network for improved glioma grading
Sreedevi Gutta, California State University San Marcos, United States
Accurate prediction of glioma grade is significant for treatment planning and management. Prior studies require a segmentation network to extract the tumor region, which was then used by classification network for grade prediction. However, tumor segmentation was a challenging pr [....] » Read More
Title : Cancer: An overview
Harris Phillip, NHS, United Kingdom
In this presentation, I will explore the growth of cancer treatment and recognise some of our failures. I will lament that despite the strides made we are unable to find a cure. We will reflect on the papyrus papers in which is a description of the way cancer can be treated but a [....] » Read More