Clinical trial design is an essential component of advancing cancer treatment, and innovations in this area are critical to improving patient outcomes. New methodologies focus on more flexible trial designs, such as adaptive trials, which allow modifications to be made based on interim results, speeding up the process of identifying effective treatments. Patient recruitment is also a key area of improvement, with efforts to include more diverse populations in clinical trials to ensure treatments are effective across different demographics. Precision medicine is shaping clinical trial design by tailoring treatments to the genetic makeup of individuals, increasing the likelihood of success. These innovations not only optimize the trial process but also help deliver better therapies to patients more efficiently.