Combination therapies leverage the synergistic effects of multiple treatment modalities, such as chemotherapy, radiation, and immunotherapy, to enhance therapeutic efficacy. These approaches aim to overcome resistance mechanisms, target multiple cancer pathways, and achieve better outcomes than monotherapies. For instance, chemo-radiation has become a standard for treating certain solid tumors, while combining immunotherapy with targeted therapies has shown promise in advanced cancers. Clinical trials investigating these combinations provide insights into optimal dosing, sequencing, and patient selection, paving the way for more personalized and effective cancer care strategies.