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COPD 2021

Rekha Khandia

Rekha Khandia, Speaker at Pulmonology Congress
Barkatullah University, India
Title : Role of Parainfluenza virus (PIV) and Human metapneumo virus (HMPV) and their codon choices involved in causing lung infection


At present, almost all countries are suffering with the deadly consequences of the SARS CoV-2 virus. Though ~80% among affected patients get recovered from this disease but patients suffering from comorbidities especially heart and lung diseases like, COPD (Chronic Obstructive Pulmonary Disease), asthma, lung cancer, etc. are at high risk of fatal consequences of the viral infection. As the disease COVID-19 caused by the SARS CoV-2 in such patients affect the airflow and increases inflammation in respiratory tract further leading to death. Other viruses like parainfluenza virus (PIV) and human metapneumo virus (HMPV) are minor pathogens like coronaviruses, also affect all age group including children suffering from asthma. These viruses are contagious and classified under the same family Paramyxoviridae. We performed computational study involving various CUB indices to understand the synonymous codon usage pattern and host adaptation of both PIV and HMPV viral genome using the genome sequences available on NCBI. In this study, we have considered a total of 120 transcripts (30 transcripts of PIV and 90 transcripts of HMPV) that are an exact multiple of three bases and having a start and stop codon without any unknown base (N) in the entire length of coding sequences. The nucleotide composition analysis, in both PIV and HMPV, depicted A and T preference over G and C at first and third codon positions. The RSCU analysis represented A/U ending codons preference over G/C ending codons in both the viral genome. Codon adaptation index (CAI), RCDI and similarity index are the major parameters that reveals host relatedness, the present study showed strong host adaptation for Homo sapiens.


Dr. Rekha Khandia, M.Sc., Ph.D. (Biotechnology) is an assistant professor at the Department of Biochemistry & Genetics, Barkatullah University, Bhopal (India). She achieved her graduate and post-graduate degree at the Institute of Microbiology and Biotechnology, University Teaching Department (UTD), Bhopal. She carried out research work on anthrax and did her Ph.D. degree in 2009 at ICAR- National Institute of High-Security Animal Diseases, Bhopal. She received many national and state-level awards in literature and science and fellowships due to her outstanding performance throughout her academics. She developed interest and expertise in reverse genetics techniques that led her to generate reassortant avian influenza virus as a potential vaccine candidate against highly pathogenic avian influenza. She further worked under CDDL (Central Disease Diagnostic Laboratory, Ministry of Agriculture, Govt. of India) at ICAR- National Institute of High-Security Animal Diseases, Bhopal, during 2003-2014, an OIE (World organization for Animal health) as a research associate. She has published more than 80 research articles in Scopus Indexed Journals and received 9000+ citations. She got an appreciation letter from ICAR, Krishi Bhavan, New Delhi, for her excellent contribution in earning the recognition of “OIE referral lab” for Avian Influenza disease for ICAR-NIHSAD. This expertise remained fruitful for the country's interest in the particular case of bird-flu diagnosis and vaccination program of AIV H5N1 highly pathogenic strain.