IMPORTANT UPDATE
Over the past few days, the Organizing Committee, Editorial Team and Onsite Staff has worked continuously to organize the event in-person, but continued travel restrictions by universities and countries forced us to convert COPD 2021 to fully virtual event.
We are constantly monitoring the worldwide developments corresponding to coronavirus outbreak and the status is rapidly evolving. WHO and CDC notify large gatherings are still a high COVID-19 risk.
Many universities still have restrictions for its staff and to tackle the COVID-19 situation, most of the countries have imposed travel restrictions, border closures and mandatory self-quarantine. As the measures imposed, many participants have reported unexpected flight cancellations and limited flight availability, preventing them to join us for in-person meeting. Considering all these, the conference committee has decided to turn "International Conference on COPD and Asthma" into complete virtual event. We assure that you will have worthy interaction virtually and the program will compose high-quality talks.
Meeting invitation with login credentials will be sent to your respective emails. We very much hope to see you on-screen September 22 nd !!
For any further questions or concerns, please contact us at: [email protected]
WELCOME TO COPD 2021
Magnus Group welcomes Pulmonologists, Respirologists, Respiratory Care Practitioners, and Respiratory Medicine specialists across the world to discuss current trends in Pulmonology at the first edition of the "International Conference on COPD and Asthma" (COPD 2021) which is scheduled Virtually during September 22-23, 2021. It deals with various aspects based on the theme "Exchange questions, answers and best practices in the field of COPD and Asthma”.
The aim of this conference is to learn and share innovative ideas and developments on current research by gathering leading worldwide researchers, industry researchers, scholars, decision-makers, and other professionals in COPD and Asthma. This COPD 2021 conference is going to be one of the most remarkable events of the year.
COPD 2021 will entail world-class keynote talks, speakers presenting their research works in the form of oral and poster presentations with interactive networking sessions, one-to-one meetings, exhibitor presentations, and workshops.
Upcoming Conferences: COPD Conferences 2021 | Pulmonology Conferences | Lung Conferences | COPD 2021 | COPD Congress | Pulmonology Conference 2021
Earlybird Registrations Closes on August 17th 2021
Scientific Sessions
- Chronic Obstructive Pulmonary Disease
- Asthma and Allergy
- Stages of Asthma
- Diagnosis methods for Pulmonary disorders
- COPD Pathogenesis
- Lung Transplantation
- Pediatric Pulmonology & Critical care
- Pulmonary Rehabilitation
- Respiratory Tract Infections
- Cardio Pulmonary Disorders
- COPD and Air Pollution
- Respiratory and sleep Medicine
- Respiratory Failure and COPD Complications
- Self-Management and Prevention of COPD
- Asthma Immunopathology
Scientific Committee Members
Allen Fred Fielding
Temple University, USA
John Kirkpatrick Field
University of Liverpool, UK
Jacqueline McGlade
UCL Institute for Global Prosperity, UK
Jordan Minov
Institute for Occupational Health of R. North Macedonia, R. North MacedoniaSpeakers
Rodney E. Wegner
Allegheny Health Network Cancer Institute, USA
Pier Luigi Paggiaro
University of Pisa, Italy
Athanasios Colonias
Allegheny Health Network Cancer Institute, USA
Zachary D Horne
Allegheny Health Network Cancer Institute, USA
Simon Walsh
Pfizer Healthcare Ireland, Ireland
Maria Semitekolou
Biomedical Research Foundation of the Academy of Athens, Greece
Ana Beatriz Villasenor-Altamirano
UNAM-LIIGH, Mexico
Valerii A. Voinov
Pavlov First Saint Petersburg State Medical University, Russia
Irine Pkhakadze
Akaki Tsereteli State University, Georgia
Elizabeth Aitcheson
Liverpool Heart and Chest Hospital, United KingdomMedia Partners
Past Conference Information
2nd Edition of International Conference on Oncologyand Radiology 2018 Report:
Magnus Group Successfully completed “2nd Edition of International Conference on Oncology and Radiology which was held in Rome, Italy, during September 17-19, 2018.
Cancer Conference 2018 witnessed an amalgamation of outstanding speakers who enlightened the crowd with their knowledge and confabulated on various new-fangled topics related to the field of Oncology and Radiology. The extremely well-known conference hosted by Magnus Group was marked with the attendance of young and brilliant researchers, business delegates and talented student communities representing diverse countries around the world.
For ICOR 2018 Final Program: Click Here
For ICOR 2018 Abstract Book: Click Here
For ICOR 2018 Gallery: Click Here
Magnus Group is privileged to thank the Organizing Committee Members and Keynote Speakers for making their contributions in the form of very informative presentation
Lucio Miele, Louisiana State University Health Sciences Center, USA
Elizabeth Franzmann, Vigilant Biosciences, USA
Rossana Berardi, Universita Politecnica delle Marche, Italy
Tamara Lah Turnsek, National Institute of Biology, Slovenia
Jozef Sabol, Department of Crisia Management, PACR, Czech Republic
Upcoming COPD Conferences: COPD Conferences 2021 | Pulmonology Conferences | Pulmonology Conferences 2021 | Asthma Conferences | Asthma Conferences 2021
ICOR 2018 Speaker Line Up:
Victoria Seewaldt, City of Hope Comprehensive Cancer Center, USA
Annika Lindstrom, CKF Dalarna, Uppsala University, Sweden
Francesco Izzo, National Cancer Institute of Naples, Italy
Jerome Paillassa, Centre Hospitalier Universitaire d'Angers, France
Yaoru Huang, Taipei Medical University Hospital, Taiwan
Igor Pogrebniakov, SRI of clinical and experimental radiology of N.N.Blokhin CRC, Russian Federation
Erwin Danil Yulian, University of Indonesia, Indonesia
Surajit Pathak, Chettinad Academy of Research and Education, India
Joshua D. Palmer, Ohio State University Wexner Medical Center, United States
Mark S. Parker, VCU Medical Center, USA
Francesco Giovinazzo, University Hospital of Southampton NHS Foundation Trust, UK
Myron R. Szewczuk, Queen’s University, Canada
Giulia Zumbo, Southampton General Hospital, Uk
Marina De Rosa, University of Naples Federico II, Italy
Jose Carlos dos Santos, Universitatsklinikum Heidelberg, Germany
Chiu Sai Yiu Richard, Hong Kong Baptist Hospital, Hong Kong
Neeraj Jain, Sri Guru Ram Das University of Health Science, India
Ivana Jovcevska, University of Ljubljana, Slovenia
Cagri Oner, Maltepe university, Turkey
Bahadir Batar, Namik Kemal University School of Medicine, Turkey
Ocung guido, Makerere University, Uganda
Jalil Ur Rehman, Baluchistan University of Information Technology Engineering , Managements and Science, Pakistan
ICOR 2018 Poster Presenters:
Joo Hee Yoon, The Catholic University of Korea, Korea, Republic of
Martina Seifrtova, Charles University, Czech Republic
Masaru Shimada, Yokohama City University, Japan
Radim Havelek, Charles University, Czech Republic
Jung Hwan Yoon, The Catholic University, Korea, Republic of
Miyoung Park, The Catholic University of Korea, Korea, Republic of
Chae Ri Park, Asan medical center (AMC), Korea, Republic of
Youn Kyoung Jeong, Korea Institute of Radiological & Medical Sciences, Korea, Republic of
Jan Marek, Faculty Hospital Hradec Kralove, Czech Republic
Magnus Group would like to thank all the participants for their wonderful involvement towards the event which helped us for successful execution of this event.
Upcoming COPD Conferences: COPD Conferences 2021 | Pulmonology Conferences | Pulmonology Conferences 2021 | Asthma Conferences | Asthma Conferences 2021
Details of upcoming COPD Conferences :
| Conference Name | Place | Date |
| COPD Conference 2021 | Paris, France | September 22-23, 2021 |
3rd Edition of Global Conference on Pharmaceutics and Drug Delivery Systems (PDDS 2019) Report:
Magnus Group successfully completed 3rd Edition of Global Conference on Pharmaceutics and Drug Delivery Systems (PDDS 2019) at Paris, France during June 24-26, 2019.
Day 1: June 24, 2019 (Monday)
The conference was initiated by Moderator Fabien Gosselet from Blood-brain barrier laboratory, Artois University, France with the Honourable presence of the Keynote forum. The list includes:
Vladimir P. Torchilin, Northeastern University, USA
Robert Houlden, Formulytica Pty. Ltd, Australia
Robert P. Bianchi, Prescription Drug Research Center, USA
Georgina Kate Such, University of Melbourne, Australia
Oral Presentations were held on Novel Developments In Drug Delivery System, Formulation Technologies, Advanced Drug Delivery Systems, Drug Delivery Through BBB, Biodrugs, Biomolecules and Therapeutics Session under the guidance of Session chairs.
Day 1 Speakers with their Presentation Details:
Upcoming COPD Conferences: COPD Conferences 2021 | Pulmonology Conferences | Pulmonology Conferences 2021 | Asthma Conferences | Asthma Conferences 2021
| Title: Docetaxel-liposomes prepared by the dual centrifugation method: Effect of propylene glycol and lipid charge on liposomal characteristics |
| Ann Mari Holsæter, The Arctic University of Norway, Norway |
| Title: Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments |
| Jan Tavernier, UGent/VIB, Belgium |
| Title: Lipid and carbohydrate based delivery vesicles for gene therapeutics: Approaching difficult diseases |
| Kira Astakhova, Technical University of Denmark, Denmark |
| Title: In vitro modeling of the blood-brain barrier to assess CNS drug delivery |
| Fabien Gosselet, Blood-brain barrier laboratory, Artois University, France |
| Title: Prototyping and evaluating a novel humanoid chewing robot for drug delivery using a medicated chewing gum |
| Kazem Alemzadeh, University of Bristol, UK |
| Title: Multifunctionalized and targeted biocatalytic nanoreactor for combinatory treatment of ER+ breast cancer |
| Rafael Vazquez-Duhalt, Universidad Nacional Autónoma de México, Mexico |
| Title: New approach to study difference in NSAIDs enantiomer activity, including chiral inversion |
| Tatyana Viktorovna Leshina, Voevodsky Institute of Chemical Kinetics and Combustion of Russian Academy of Science, Russia |
| Title: In situ delivery and production system of anti-cancer molecules with gene-engineered |
| Shun’ichiro Taniguchi, Shinshu University School of Medicine, Japan |
| Title: Influence of mucoadhesivity on the bioavailability of nanoparticulate drug delivery systems |
| Ylenia Zambito, University of Pisa, Italy |
| Title: Systemic liver-targeting delivery of a novel DNA/RNA heteroduplex oligonucleotide via an enteral route |
| Chie Watanabe, Josai University, Japan |
| Title: Physicochemical and biophysical study of mechanisms the drugs bioavailability enhancement with new multifunctional delivery systems |
| Nikolay E. Polyakov, Voevodsky Institute of Chemical Kinetics and Combustion of Russian Academy of Science, Russia |
| Title: Designing ADME formulations with matching exposures to amorphous solid dosage forms |
| Aditya Tatavarti, Merck Sharp & Dohme Inc, USA |
| Title: Wound healing mats made of layer by layer coated nanoparticles and electrospun nanofibers |
| Gulcin Arslan Azizoglu, Ege University, Turkey |
| Title: In vitro model of diclofenac sodium gel delivery through pig skin |
| Enkelejda Goci, Aldent University, Albania |
| Title: Influence of formulation and freeze drying process variations on protein stability |
| Paritosh Pande, IMA Life North America and University of Connecticut, USA |
| Title: Valproic acid encapsulated biodegradable microneedles for treatment of androgenetic alopecia |
| Shayan Fakhraei Lahiji, Yonsei University, South Korea |
| Title: Therapeutic effects of trehalose liposomes against tumors along with apoptosis |
| Yoko Matsumoto, Sojo University, Japan |
Day 2: June 25, 2019 (Tuesday)
Day 2 was initiated by Moderator: Elinaz Farokhi from San Diego State University, USA and the Keynote Forum included:
Mino R. Caira from University of Cape Town, South Africa
Angelita Rebollo from CIMI Paris, France
Rui Tamura from Kyoto University, Japan
Oral Presentations were held on Nanotechnology in Pharmaceutics and Drug delivery systems, Pharmacovigilance and Drug Safety, Therapeutic Drug Carrier Systems, Cellular Targeting and Intracellular Delivery, Pharmaceutical Microbiology and Biotechnology, Vaccine design and drug delivery technology
Day 2 Speakers with their Presentation Details:
| Title: Nano- versus micro-particles for S-nitrosoglutathione formulation |
| Marianne Parent, Université de Lorraine, France |
| Title: Pseudomonas aeruginosa type 3 secretion system mediated antigen delivery for cancer immunotherapy |
| Toussaint Bertrand, University Grenoble Alpes, France |
| Title: Engineering novel selectivity into metalloantibodies germline-encoded precursor to the murine anti-S1P metalloantibody in E.coli and baculovirus-insect cell system |
| Elinaz Farokhi, San Diego State University, USA |
| Title: Discovery of novel bacterial genes encoding the enzymes acting on modified uracil/uridine derivatives and their use for gene therapy in cancer treatment |
| Jaunius Urbonavi?ius, Vilnius Gediminas Technical University, Lithuania |
| Title: Drug delivery to the skin: Nanostructures for the treatment of precancerous actinic keratosis |
| Silvia Tampucci, University of Pisa, Italy |
| Title: Liposomes as valuable drug delivery systems for siRNA and Hsp90 inhibitors to target triple negative breast tumors |
| Juliette Vergnaud-Gauduchon, Université Paris-Sud, France |
| Title: A RNA producing DNA hydrogel as a platform for a high performance RNA interference system |
| Nokyoung Park, Myongji University, South Korea |
| Title: Metal-organic framework nanoparticles preparation of sildenafil: A new window in the treatment of pulmonary arterial hypertension |
| Haissam Abou Saleh, Qatar University, Qatar |
| Title: Release and activity of the broad spectrum antibiotic Rifampicin from biodegradable polymer PLGA |
| Justine Fraser, The University of Strathclyde, UK |
| Title: Role of the optimal dynamic state and stabilized catalytic complex for rational design of pharmaceutical enzymes: Engineering of streptokinase with enhanced, fibrin-dependent activity |
| Farzin Roohvand, Pasteur Institute of Iran, Iran |
| Title: Pharmacovigilance: Aims, challenges and perspective |
| Razan Ghattas Mhanna, Lebanese International University, Lebanon |
| Title: Original Synthesis of natural acetogenins, fattyacids and lembehynes as a potential drugs for treatment of cancer and neurodegenerative diseases |
| Vladimir A. D’yakonov, Institute of Petrochemistry and Catalysis of RAS, Russia |
| Title: The nuclear membrane as a barrier to the action of anthracycline chemotherapeutics |
| Gulnihal Ozcan, Koc University Research Center for Translational Medicine, Turkey |
| Title: Global legal tools for pharmacovigilance and risk control |
| Eliana Silva De Moraes, Partner at Silva de Moraes Associes, France and Brazil |
| Title: Self-propelled objects with high autonomy for transportation |
| Satoshi Nakata, Hiroshima University, Japan |
Poster Presentations held on Day 2 included presentation from various topics on pharmaceutics, drug safety, drug delivery, Nanotechnology in Pharmaceuticsand Drug delivery systems, Pharmacovigilance and Drug Safety, Therapeutic Drug Carrier Systems, Cellular Targeting and Intracellular Delivery, Pharmaceutical Microbiology and Biotechnology, Vaccine design and drug delivery technology, Novel Developments In Drug Delivery System, Formulation Technologies, Advanced Drug Delivery Systems, Drug Delivery Through BBB, Biodrugs, Biomolecules and Therapeutics and many more…
Poster Presenters with their Presentation Details:
| Title: HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors |
| Mamuka Kvaratskhelia, University of Colorado School of Medicine, USA |
| Title: Study of the capability of Chitosan-Glutathione nanoparticles to modulate redox state in human Chondrocytes |
| Roberto Diaz-Torres, National University of Mexico, Mexico |
| Title: The biomedical application of biogenic silver nanoparticles produced from Cotyledon orbiculata |
| Samantha Meyer, Cape Peninsula University of Technology, South Africa |
| Title: Nano-amorphous abiraterone acetate formulation with improved bioavailability and eliminated food effect |
| Tamás Jordán, NanGenex Inc, Hungary |
| Title: Dissolution study of drug release from biopolymer matrix tablets |
| Kevin Matzick, University of Pardubice, Czech Republic |
| Title: TAA-induced liver damage in KLF10 knockout mice |
| Azra Memon, Inha University, Republic of Korea |
| Title: Neuropeptide Y-based recombinant peptides improve bone loss in mice by regulating hematopoietic stem/progenitor cell mobilization |
| Hee Kyung Jin, Kyungpook National University, Republic of Korea |
| Title: Antitumor effects of retargeted AAV2 virus on ovarian cancer in vivo |
| Hyung Jun Ahn, Korea Institute of Science and Technology, South Korea |
| Title: Niosomal encapsulation of Curcumin: Characterization and its potential as a therapeutic intervention in asthma |
| Dinesh Kumar Chellappan, International Medical University, Malaysia |
| Title: Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells |
| Jiyon Lee, Konkuk University, Republic of Korea |
| Title: Kinetics of pentoxifylline release from hydrophilic, lipophilic and dual matrix tablets |
| Barbora Slezáková, University of Pardubice, Czech Republic |
| Title: Development of rotigotine nanoparticles and its effect on haloperidol induced Parkinsonian symptoms in rats |
| Subrat Kumar Bhattamisra, International Medical University, Malaysia |
| Title: Synthesis, evaluation and computational simulation of novel coumarin derivatives as potential acetylcholinesterase inhibitors |
| Haeil Park, Kangwon National University, Republic of Korea |
| Title: Characterization and validation of tumor cell-selective penetrating peptides |
| Angelita Rebollo, CIMI Paris, France |
| Title: Freshwater sapropel extract for use in medicine and pharmaceutics |
| Aneka Klavina, Rigas Stradi?š University, Latvia |
| Title: Fabrication and characterization of transdermal patch loaded with Ascorbic acid |
| Ahlam Zaid Alkilani, Zarqa University, Jordan |
| Title: Nanoemulsion–laden organogels of lidocaine as lipid–based systems for topical delivery |
| Rania Hamed, Al-Zaytoonah University of Jordan, Jordan |
| Title: Anti-cancer effect of Tuberatolide B in MDA-MB-231 cells through induction of ROS and inhibition of STAT3 pathway |
| Areumi Park, Korea Institute of Ocean science & Technology, Republic of Korea |
| Title: Protective effect of Bis (3-bromo-4,5-dihydroxybenzyl) ether against LPS-induced inflammatory response in RAW 264.7 macrophages through ROS-mediated ERK signaling pathway |
| Soo-Jin Heo, Korea Institute of Ocean science & Technology, Republic of Korea |
| Title: Saringosterol acetate suppressed hepatocelluar carcinoma growth and metastasis in a zebrafish xenograft model |
| Eun-A Kim, Korea Institute of Ocean science & Technology, Republic of Korea |
| Title: Molecular weight characterization of sodium carboxymethyl cellulose by advance polymer chromatography |
| Ekaterina Sobich, AbbVie Deutschland GmbH & Co. KG R&D, Germany |
| Title: Strategies to increase the passage of large molecules through the blood brain barrier |
| Charlotte Lombardi, Grenoble-Alpes University, France |
| Title: Peptide functionalized nanoparticles for the selective induction of apoptosis in target cells |
| Mervin Meyer, University of the Western Cape, South Africa |
| Title: Cell-free expression of a membrane antigen for vaccine uses |
| Geraldine Mayeux, University Grenoble Alpes, France |
| Title: Thermoresponsive in situ gelling systems for ophthalmic drug delivery |
| Concepción Renedo Laguna, University of Seville, Spain |
Best poster awards was received by:
Rania Hamed, Al-Zaytoonah University of Jordan, Jordan
Mervin Meyer, University of the Western Cape, South Africa
Day 3: June 26, 2019 (Wednesday)
Moderator: Maria van Dongen from The Janssen Pharmaceutical Companies of Johnson & Johnson, Belgium has initiated the keynote session which included:
Ülo Langel from Stockholm University, Sweden
El Hassane Larhrib from University of Huddersfield, UK
Marlene Lúcio from CF-UM-UP, Portugal
Amanda Silva Brun from CNRS, Université Paris-Diderot, France
Oral Presentation on Day 3 were held on Advances in Biotherapeutics-Drug Discovery and Development, Drug discovery and Screening, Pharmaceutical Analysis and Quality Assurance , Pharmaceutical Research & Development sessions
Day 3 Speakers with their Presentation Details:
| Title: Antibody-guided discovery of potent small-molecule fusion inhibitors of influenza virus |
| Maria van Dongen, The Janssen Pharmaceutical Companies of Johnson & Johnson, Belgium |
| Title: Targeting liver function to circumvent neuronal and cardiac dysfunctions linked to hyperhomocysteinemia |
| Nathalie Janel, University Paris Diderot, France |
| Title: Detection of “Hidden” drug resistance by the EZMTT assay |
| Benfang (Bennie) H. Ruan, Zhejiang University of Technology, China |
| Title: New indications for FDA-approved drugs: Selective inhibition of the growth of Helicobacter pylori by covalent allosteric regulation of urease |
| Fang Wu, Shanghai Jiao Tong University, China |
| Title: Chimeric antigen receptor(CAR)-T CELL; a biodrug as cancer therapeutic agent |
| Preeti Sharma, Satosh Medical College and Hospital, India |
| Title: Freshwater Sapropel as raw material in medicine and pharmaceutical production |
| Agris Auce, Rigas Stradins University, Latvia |
| Title: P-selectin targeted nanocarriers are efficient drug delivery systems to activated endothelium |
| Manuela Calin, Institute of Cellular Biology and Pathology “N. Simionescu”, Romania |
| Title: Development of novel leads for triple-negative breast cancer immunotherapy |
| Jing Yu, Shanghai Jiao Tong University, China |
| Title: Novel small molecules for PPARs modulation and their potential use for treatment of metabolic disorders |
| Antonio Laghezza, Università degli Studi di Bari “Aldo Moro”, Italy |
| Title: Caloric restriction and longevity |
| Bartolome Ribas Ozonas, Royal National Academy of Pharmacy, Institute of Spain. Madrid, Spain |
| Title: Synactix Inc and academic case studies of targeted therapy |
| Hong-yu Li, University of Arkansas for Medical Sciences, USA |
| Title: Liposomal encapsulation of silver nanoparticles suppresses nanoparticle-induced ROS and inflammation, and induces caspase-dependent apoptosis |
| Azeez Yusuf, Technical University Dublin, Ireland |
| Title: Development of substances with biological and pharmacological activity based on structural nucleus hybrids from phytochemical compounds like secondary metabolites |
| José Eduardo Cuéllar, Universidad Nacional de Colombia, Colombia |
| Title: Aspects of controlled-release dosage forms in veterinary medicine with emphasis on GRDF |
| Eran Lavy, Hebrew University of Jerusalem, Israel |
Upcoming COPD Conferences: COPD Conferences 2021 | Pulmonology Conferences | Pulmonology Conferences 2021 | Asthma Conferences | Asthma Conferences 2021
Conference Schedule
12:00-12:10 (GMT)
12:10-15:30 (GMT)
Keynote Session
15:30-15:50 (GMT)
Refreshment Break
15:50-17:30 (GMT)
Break Out Session I
17:30-17:50 (GMT)
Refreshment Break
17:50-19:30 (GMT)
Break Out Session II
12:00-12:10 (GMT)
Introduction
12:10-15:30 (GMT)
Keynote Session
15:30-15:50 (GMT)
Refreshment Break
15:50-17:30 (GMT)
Break Out Session I
17:30-17:50 (GMT)
Refreshment Break
17:50-18:50 (GMT)
Poster Session
18:50-19:30 (GMT)
Prize Distribution and Closing Ceremony
Get in Touch Make Inquiry
Please feel free to contact us for any information, all the queries will be answered by the conference secretariat within 24 hrs.
Videos Gallery (Our Past Events)
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Cancer Conference 2018 | Rome, Italy
Pharma Conference 2017 | Valencia, Spain
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Testimonials
I want to thank for the tremendous work on the organization of the forum and the success of the event. Impressions are the most positive. I hope for further meetings and wish you all good luck.
It was fruitful meeting and there were many interesting presentations from the field of plant science and biotechnology
Thank you very much for such a wonderful Congress! I was very glad to spend these wonderful days with you. I hope to see you soon.
It was well attended with very timely presentation. Once again, this was one of the best organized international conferences I have ever had.
