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COPD 2022

Piotr kusnierczyk

Piotr kusnierczyk, Speaker at COPD congress 2022
Polish Academy of Sciences, Poland
Title : Genetics of endoplasmic reticulum aminopeptidases in non-small cell lung cancer - differences between smokers and never-smokers



Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components, of which endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) are most genetically polymorphic. We compared the distribution of ERAP1 and ERAP2 single nucleotide polymorphisms (SNPs) in Polish patients with non-small cel lung cancer (NSCLC) and controls, stratified according to their smoking status. We found significant but opposite associations in never-smokers and in smokers of all tested SNPs (rs26653, rs2287987, rs30187, and rs27044) but one (rs26618) in ERAP1. No significant associations were seen in ERAP2. Haplotype analysis indicated that the distribution of many ERAP1/2 haplotypes is opposite, depending on smoking status. Additionally, haplotypic combination of low activity ERAP1 and the lack of an active form of ERAP2 seems to favor the disease in never-smokers. We also revealed interesting associations of some ERAP1 polymorphisms with: age at diagnosis (rs26653), disease stage (rs27044), overall survival (rs30187), and response to chemotherapy (rs27044). The results presented here may suggest the important role for ERAP1 in the anti-cancer response, which is different in smokers versus never-smokers, depending to some extent on the presence of ERAP2, and affecting NSCLC clinical course.


Piotr Kusnierczyk currently works at the Department of Clinical Immunology, Polish Academy of Sciences. Piotr does research in Immunology and Genetics. He was born in 1943 in Warsaw. Piotr Kusnierczyk received his Master's in Biology in 1965, Jaguellonian University, Cracow, Poland and did his Master in Biochemistry in 1868, at the University of Wrocław, Wrocław, Poland. He was a visiting scientist in the College of Georgia, Augusta, the USA in 1998. He achieved the promotion of Science research fellow in the Japan Society from the Department of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan in 1987. Piotr Kusnierczyk is also the titular Professor and Head of the Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wrocław, Poland in present 2006. Piotr Kusnierczyk achieved the membership in the Polish Society of Experimental and Clinical Immunology, Polish Society of Immunogenetics, The European Alliance of Associations for Rheumatology, Study Group on MHC-I-opathy. He has more than 121 publications in Pubmed. Their most recent publication is 'HLA-C*06:02-independent, a gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis. He has 178 publications in various journals.