Title : Biocompatibility of calcium silicate-based root canal sealers
Abstract:
Endodontic treatment is a multi-step procedure, and different materials are used in this process. Endodontic materials should be biocompatible, non-toxic, well tolerated by periapical tissues, and stimulating healing properties. Biocompatibility is the compatibility of the material with the biological functions of tissues while in contact with vital tissues without causing tissue reactions such as systemic or local toxicity, allergic, genotoxic, mutagenic, and carcinogenic effects. The biocompatibility of root canal sealers is very important. Root canal sealers, which can cause a toxic reaction and tissue necrosis, may prevent tissue healing as well as affect the success of endodontic treatment. Bioactive materials are used in endodontic procedures to improve healing results. In endodontics, root canal sealers with different contents and properties are classified in various forms. Calcium silicate-based root canal sealers are becoming popular in endodontics due to their strong biological attractiveness, supported by various studies showing their biocompatibility and bioactivity. Tri/dicalcium silicate-based root canal sealers are marketed under different brand names. Tricalcium silicate materials exhibit bioactive properties due to their ability to form hydroxyapatite on their surfaces and osteogenic effect. This presentation aims to review the biocompatibility properties of calcium silicate-based root canal sealers, with an emphasis on their benefits, shortcomings, and clinical applications, and propose rational indications for these sealers based on available information. Thus, it will help to provide a perspective on developments in this field.
