HYBRID EVENT: You can participate in person at Singapore or Virtually from your home or work.

8th Edition of International Conference on
Dentistry and Oral Health

March 25-27, 2024 | Singapore
Dental 2022

Takehisa Iwai

Takehisa Iwai, Speaker at Dental Conferences
Tsukuba Vascular Center, Japan
Title : Periodontal bacteria induced arterial and venous thrombus in the rats: Its pathology, immunology and the pathogenesis for Buerger disease and atherosclerosis


Periodontal bacteria had been detected from various vascular disease or related disorders. And statistically these are believed as one of the pathogenesis of the diseases. However, the pattern of the reaction and inflammation analysis has been unclear. Our rat model revealed that the inflammatory reaction including natural immunological reaction demonstrated clearly. And pathological changes were strongly similar to Buerger disease (thromboangiitis obliterans). When the atherosclerotic factors including hypertension, diabetes, or hyperlipidemia are mixed, pathological changes are estimated to contribute to the atherosclerosis progress occurred in the heart, brain, carotid arteries and so on. We show the clinical cases including other hypothesis. In these discovery, as the intimal trauma is initiated by lipo-poly-saccharides (LPS), pathogen must be Gram negative anaerobic bacteria. The bacteria live a short time (several hours) and die soon. We named it ‘Kamikaze infection’ (not real infection).


Emeritus Professor of Tokyo Medical and Dental University, Director of Tsukuba Vascular Center, and President of Japanese Society pf Phlebology.

Major field: Vascular Surgery.

Education: 1967 Tokyo Medical and Dental Univ. Faculty of Medicine graduation.

Professional experience: 1992 Associate Prof. Tokyo Medical and Dental Univ. 1st Dep. of Surgery.1997 Prof. Tokyo Medical and Dental Univ. 1st Dep. of Surgery. 2000 Prof Tokyo Medical and Dental Univ. Graduate School of Medicine, 2007 Director of Tsukuba Vascular Center. Award: International Union of Angiology 1st Prize, London.
Short Bio:1978 Ph.D. Tokyo Medical and Dental Univ. Honor member of Japanese Society of Vascular Surgery.