Periodontal bacteria induced arterial and venous thrombus in the rats: Its pathology, immunology and the pathogenesis for Buerger disease and atherosclerosis

Periodontal bacteria had been detected from various vascular disease or related disorders. And statistically these are believed as one of the pathogenesis of the diseases. However, the pattern of the reaction and inflammation analysis has been unclear. Our rat model revealed that the inflammatory reaction including natural immunological reaction demonstrated clearly. And pathological changes were strongly similar to Buerger disease (thromboangiitis obliterans). When the atherosclerotic factors including hypertension, diabetes, or hyperlipidemia are mixed, pathological changes are estimated to contribute to the atherosclerosis progress occurred in the heart, brain, carotid arteries and so on. We show the clinical cases including other hypothesis. In these discovery, as the intimal trauma is initiated by lipo-poly-saccharides (LPS), pathogen must be Gram negative anaerobic bacteria. The bacteria live a short time (several hours) and die soon. We named it ‘Kamikaze infection’ (not real infection).