Blood & its products as regenerative agents in Dentistry

Bone regeneration in dentistry involves the use of cells, biological or artificial biometric scaffolds, and biofactors that promote cell growth and differentiation along complex pathways to repair the tissue. Growth factors have a crucial role in this process since they influence the chemotaxis, differentiation, proliferation, and synthetic activity of bone cells, thereby regulating physiological remodeling and bone healing. That makes the use of autologous and recombinant growth factors (GF) a rapidly growing field of regenerative dentistry focusing on manipulating GF and secretory proteins to maximize the healing of bone and soft tissues. Most of the growth factors derived from autologous blood are released upon platelet activation, and their clinical use has been popularized with Platelet-rich plasma (PRP), Platelet-rich fibrin (PRF) & its advancements namely A-PRF& i-PRF, Concentrated Growth Factors (CGF), Sticky Bone Concept, etc. It is time to use this ‘BLOOD’ in different ways to achieve regenerative potential in the field of dentistry.