Title : Inflammatory cytokines cell expression to predict the malignant transformation of oral mucosal lichen planus
Abstract:
Introduction:
Oral Mucosal Lichen Planus (OMLP) is a common disease where current evidence have shown cell-mediated immunity are involved in the cause of OMLP.
A new IL-17 producing CD4 T cell Subset, Th17, is thought to play a role in maintaining this immune system equilibrium. Recently Th17 (CD4+ IL-17) cells were identified in periodontal disease tissue and were thought to play a role in pathogenesis of periodontal disease.
Oral Mucosal Lichen Planus (OMLP) is a common disease where current evidence have shown cell-mediated immunity are involved in the cause of OMLP.
A new IL-17 producing CD4 T cell Subset, Th17, is thought to play a role in maintaining this immune system equilibrium. Recently Th17 (CD4+ IL-17) cells were identified in periodontal disease tissue and were thought to play a role in pathogenesis of periodontal disease.
Materials and Methods:
To determine, through a literature review, whether Th17 immune cell expression is associated with the clinical type and pathogenesis of oral mucosal lichen planus (OMLP).
To determine, through a literature review, whether Th17 immune cell expression is associated with the clinical type and pathogenesis of oral mucosal lichen planus (OMLP).
Results & Discussion:
The aetiology of OMLP remains unclear. A delayed hypersensitivity immune reaction, in which the release of cytokines by activated T cells leads to the attraction of inflammatory cells and to the destruction of keratinocytes by cell-mediated cytotoxicity, has been implicated in the pathogenesis of OLP. Recent studies indicate that the cytokine IL-17 is the major mediator of tissue inflammation in several autoimmune and inflammatory diseases, and concluded that Th17 cells may play an important role in the pathogenesis of OMLP. IL-17 can contribute in the pathogenesis of OLP by enhancing T cell-mediated reactions and inducing production of chemokines and other cytokines and therefore, predict the eventual malignant transformation of oral mucosal lichen planus (OMLP).
The aetiology of OMLP remains unclear. A delayed hypersensitivity immune reaction, in which the release of cytokines by activated T cells leads to the attraction of inflammatory cells and to the destruction of keratinocytes by cell-mediated cytotoxicity, has been implicated in the pathogenesis of OLP. Recent studies indicate that the cytokine IL-17 is the major mediator of tissue inflammation in several autoimmune and inflammatory diseases, and concluded that Th17 cells may play an important role in the pathogenesis of OMLP. IL-17 can contribute in the pathogenesis of OLP by enhancing T cell-mediated reactions and inducing production of chemokines and other cytokines and therefore, predict the eventual malignant transformation of oral mucosal lichen planus (OMLP).
Conclusion:
In conclusion, this literature review suggests a possible role of IL-17 in the pathogenesis of OMLP and may support a hypothesis that shifting of the immune system towards a Th17 response may be involved in OMLP.
In conclusion, this literature review suggests a possible role of IL-17 in the pathogenesis of OMLP and may support a hypothesis that shifting of the immune system towards a Th17 response may be involved in OMLP.
