Title : Biomimetic synthesis of drug-nanoparticles: an excipient free novel drug delivery system to treat skin fibrosarcoma in model animals
Abstract:
Nanomedicines have been widely exploited in target specific delivery of core pharmaco-materials. Traditional pharmaceutical approaches, implied in the synthesis of nano-sized formulations, need special types of chemical agents and appliances. The high end infrastructure, special storage conditions and other related matters required in the development of nano-formulations, make the whole process very expensive and thereby cannot be afforded by the common man. Besides, existing methods also rely on usage of additives or excipients, a special class of chemicals. Barring few exceptions, the usage of excipients is curtailed by several undesirable features. Such issues necessitate strategies that lead to development of an excipient free drug delivery system. Considering the fact that plant-based extracts have great potential to induce synthesis of metal core based nano-particles. In the present study, we propose a prototype employing various types of plant extract that facilitates green synthesis of nano-sized supra-molecular assemblies of some potent, organic molecules based, antimicrobial and anticancer drugs. The as-synthesized nanoparticles not only retained the pharmacological activity of the parent compound, however, also improved their efficacy against both cancer as well as microbial diseases.
