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8th Edition of

International Conference on Materials Science and Engineering

March 10-12, 2025 | Rome, Italy

Materials 2025

Exploring graphene oxide nanocomposites in cancer therapy

Speaker at International Conference on Materials Science and Engineering 2025 - Paulo Cesar De Morais
Catholic University of Brasilia, Brazil
Title : Exploring graphene oxide nanocomposites in cancer therapy

Abstract:

In this keynote talk, the use of the Hill model to assess the Benchmark dose (BMD), the lethal dose 50 (LD50), the cooperativity (E) and the dissociation constant (K) while analyzing cell viability data using nanomaterials will be explored. The presentation is addressed to discuss the antitumor potential while combining radiofrequency (RF) therapy and selected nanomaterials. In particular, it will be discussed the use of nanocomposites, for instance those comprising graphene oxide (GO) surface functionalized with polyethyleneimine (PEI) and decorated with gold nanoparticles (GO-PEI-Au). Data collected from the cell viability assays using different tumor cell lines (e.g. LLC-WRC-256 and B16-F10) will be presented and discussed. The findings will demonstrate that while the tested nanocomposite (e.g. GO-PEI-Au) may be biocompatible against different cancer cell lines in the absence of radiofrequency (nRF), the application of radiofrequency (RF) enhances the cell toxicity by orders of magnitude, pointing to prospective studies with the tested cell lines using tumor animal models.

Biography:

Professor De Morais, PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013. UnB’s Emeritus Professor (2014); Visiting Professor at the Huazhong University of Science and Technology (HUST) – China (2012-2015); Distinguished Professor at the Anhui University (AHU) – China (2016-2019); Full Professor at the Catholic University of Brasília (CUB) – Brazil (since 2018); CNPq-1A Research Fellow since 2010; 2007 Master Research Prize from UnB. Held two-years (1987-1988) post-doc position with Bell Communications Research, New Jersey – USA. Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais (UFMG) – Brazil. With more than 12,500 citations, He has published more than 500 papers (Web of Science) and more than 16 patents.

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