Title : Liposomes in Ocular Drug Delivery
Abstract:
Liposomes are known to have significance in drug delivery owing to their unique structure prove to be which enables the formulator to choose from both the hydrophilic and hydrophobic drugs as it serves promising for both. Basically, liposomes are vesicular systems which constitutes of an aqueous core surrounded by phospholipids layers of natural or man-made origin. The aqueous core can be filled with active molecule or medication and the drug delivery then takes place, thus due to this unique nature Liposomes hold a promising position in delivery of ophthalmic products. Ocular route is highly compliant to the patient however due to several disadvantages like ocular surface barriers, ocular drainage and lack of penetration limits the usage of this route. Liposome can be employed as a vectored delivery approach to the eye as is biodegradable and biocompatible nano-carrier and can widen the permeation of poorly absorbed drug molecules by binding to the corneal surface and improving residence time. Chronic ocular contagious infections such as conjunctivitis, bacterial keratitis requires formulators to elevate drug concentration at the site of infection and in addition management of these diseases requires recurrent administrations of the formulation which may result in developing drug resistance and reduces patient compliance. Ergo, In order to curtail pre-corneal drainage and increase bioavailability of the current study establishes a role of liposomal formulation for the delivery of drug targeting ocular infections.
