The global outbreak of SARS CoV2/ Covid19 is a great challenge for new concepts and strategies in different fields as glycobiology, nanomedicine or nanopharmacology. When correlating clinical data obtained from patients in intense care units with tools used in structural biology [....] » Read More
The World Health Organization and countries worldwide have acknowledged that the COVID-19 pandemic has been a fast-evolving situation and a terrible threat to people of all ages. In the face of such an alarming situation with a heavy toll on healthcare services and vulnerable ind [....] » Read More
Chemotherapy with no or minimal side effects is an urgent need. One means of attaining it is through gene delivered prodrug therapies (GDEPTs). Prodrugs are harmless until activated by a bacterial or viral gene product; they can kill tumors without side effects if the activating [....] » Read More
The most effective method of treating allergic diseases is allergen-specific immunotherapy (SIT). To reduce the risk of side effects and improve delivery of allergens to the mucosa, various delivery systems such as liposomes, dendrimers, nanoparticles, etc. can be used. Today, th [....] » Read More
Great interest has been directed towards plants as a sustainable source of antioxidant and antidiabetic materials. To avoid the destructive harvesting and promote stabilized usage of plant, leaves are used as the prime component for the study. The Phenolic compounds constitute on [....] » Read More
In the prevailing coronavirus disease-2019 (COVID) times, scientists are eager to develop vaccine against COVID-19, and careful measures are being taken to develop an effective drug. Meanwhile, several antiviral compounds have been repurposed for the COVID-19 treatment, and drug [....] » Read More
In 2020, COVID‐19 has created a major threat to human population across the world. In this pandemic, it is very difficult to discover novel drugs immediately. So, natural remedies for the prevention and treatment of COVID-19 has been widely accepted as the rapid way for effecti [....] » Read More
Vesicles are the amphilic structure having aqueous core at the center. These vesicular drug delivery systems(VDDS)have found to be more valuable for controlled drug delivery, generally classified as Lipoidal biocarriers (e.g. Liposomes, ethosomes and transfersomes) and Non-lipoid [....] » Read More
The state of one's skin has been said to represent one's overall health and age. Nutrition and its effects on the skin have raised the interest of scientists and clinicians around the world for ages. One of the elements that contribute to overall skin health is nutritio [....] » Read More
Liposomes are known to have significance in drug delivery owing to their unique structure prove to be which enables the formulator to choose from both the hydrophilic and hydrophobic drugs as it serves promising for both. Basically, liposomes are vesicular systems which constitut [....] » Read More
As per the WHO statistics, approximately 60% of the currently available anti-cancer chemotherapeutics are natural in origin. Flavonoids and Terpenoids constitute a distinct subset of such natural molecules. These molecules, found in various fruits and vegetables and other plant s [....] » Read More
Most commonly used route of administration for drugs is oral route. Poor water solubility or permeability of medications, as well as a wide pH range displayed by the gastro intestinal tract, are all obstacles to oral absorption.Hypertension, which is currently a worldwide e [....] » Read More
Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and sup [....] » Read More
Background: Drug companies rely on their marketing activities to influence physicians. Previous studies showed that pharmaceutical companies succeeded to manage physicians prescribing behavior in developed countries. However, very little studies investigated the impact of phar [....] » Read More
The current study was designing to explore the impact of pulses flour coating on fries in order to evaluate their impact on short term appetite, postprandial glucose and food intake. In first phase, the pulses (chick pea and mash bean) were procured from local market of Faisalaba [....] » Read More
pharmacopollution is a public health and environ-mental outcome of some active pharmaceutical ingredients(API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are thep harmaceutical industry, healthcare facilities (e.g., ho [....] » Read More
Information and significance of Artificial intelligence in healthcare industry, its applications, examples, AI used around the world, drug delivery through use of tools requiring intelligence, using AI powered tools in research, AI assisted surgeries.
Different chemotherapeutic strategies like Maximum Tolerable Dosing (MTD), Metronomic Chemotherapy (MCT), and Antiangiogenic (AAG) drug are available; however, the selection of the best therapeutic strategy for an individual patient remains uncertain till now. Several analytical [....] » Read More
A series of fifteen computationally bioactive 1,3-thiazolidin-4-ones fused with 1-(pyrimidin-2-yl)-1H-imidazol-4-yl moieties (1–15) were synthetically prepared and assessed for antimicrobial potential against the four strains (two gram-positive and two gram-negative). The s [....] » Read More
Nitrosamine impurities have been in the center of the stage of impurities in drug products for the past 3 years. Regulators and industry have been deliberating the methods for determining limits for this special class of mutagenic/carcinogenic impurities. Preliminary guidelines h [....] » Read More
In the search for new antibiotics with new mechanisms of action to overcome bacterial antibiotic resistance, we present our results based on sugar-based bactericides targeting membrane lipid polymorphism. The mode of action involves membrane permeabilization by local induct [....] » Read More
Wound dressing technology is of major interest in the actuality in order to avoid undesired effects when burns or skin wounds are treated, especially their risk for microbial contamination and subsequent infection. Hence, silver nanoparticles had claimed importance as an antimicr [....] » Read More
The first case of COVID-19 was reported in Malaysia on 25th January 2020. Since then, multiple series of COVID-19 waves occurred with different SARS-CoV-2 variants of concern dominating. The pandemic COVID-19 hit Malaysia with total cases of 3,528,557 and RT value of 1.02 were re [....] » Read More
Background: The advent of HAART dramatically reduced the clinical impact of HIV infection. Dual Nucleoside Reverse Transcriptase Inhibitors (NRTIs) with either protease inhibitors (PI) or Non-nucleotide/s Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are the bac [....] » Read More
Aim and Objective: To remain safe for further processing or human consumption, study of stressed degradation for the identification of feasible degradants is required. The stability indicating high performance thin layer chromatographic method was developed by using Camag HPTLC s [....] » Read More
Background and objectives: Different countries, including India witnessed sharp increase in SARS-CoV-2 cases and deaths associated with a rising proportion of B.1.617 variant. The strain was characterized by L452R and E484Q primary mutations in the receptor binding domain (RBD) d [....] » Read More
Abstract: The present study evaluated the anticancer effect of methanolic extract of Cordia dichotoma bark (MECD) against Ehrlich ascites carcinoma (EAC) cells induced in albino mice and against human cancer cell lines (MDA-MB-231 and MCF-7 cells). There were significant fall in [....] » Read More
Present study aims to utilize low temperature hot melt extrusion (HME) as a novel technology to mask bitter taste and also to develop a flexible and palatable solid oral dosage form to improve patient compliance. Pediatric patients need different oral dosage forms than adults due [....] » Read More
Bimetallic nanoparticles comprise two definite metals, having characteristic amalgamation and chemical chronology that give them unique geometry and specific functions. Bi-metallic nanoparticles also referred as doped nanoparticles show increased solubility with reduced particle [....] » Read More
The title of the talk include the information available in print meadia and e- media. The journey of Digital Drug Marketing was staretd in 1997 as Food and Drug administration, released guidelines for “Direct-to-Consumer (DTC)” advertising in this year. The talk will [....] » Read More
Recently, numerous heterocyclic compounds from the series of s-triazine and thiazolidinone have been synthesized and their pharmacological activity has therefore investigated. It has been accomplished that, s-triazine ring frame with thiazolidinone hold a extensive spectrum of bi [....] » Read More
Background: Cancer is the disease that causes the highest numbers of morbidity and mortality in the world, being one of the main symptoms chronic pain. Moderate and severe pain is usually treated with opioids, whose efficacy is proven but with several risks for the patient such a [....] » Read More
In recent years, cell cycle and checkpoint pathways regulation are offering new therapeutic approaches against cancer. 2-Indolinone, is a well exploited scaffold in the anticancer domain. Accordingly, the current work describes merged structural hybrids and ligand based design an [....] » Read More
In the present work,two plants from the Mentha genus, collected in Algeria (Mentha spicataL. and Mentha pulegium L.) were examined for radical-scavenging activity (RSA) using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic ac [....] » Read More
Microbubble and nanobubble technologies have gotten a lot of interest in recent years because of their vast range of applications in science and technology, including water treatment, biomedical engineering, and nanomaterials. There are also several intriguing physicochemical asp [....] » Read More
This study presents the in vivo and in vitro activity of dihydroanthracene disulfonic acid derivative, a new preparation with patent DE102004003030 A1. The in vivo study was performed in a 61-year-old patient of the UHC “Mother Theresa” Tirana with colon resection and [....] » Read More
Introduction and aims: Vaginal candidiasis is one of the most prevalent problems that women face throughout their lives. Considering the side effects and drug-drug interactions associated with the oral route, local administration of drugs is a first approach for the manageme [....] » Read More
Background: NF-kB contributes to the biosynthesis of various chemokines, cytokines, andenzymes. It plays many crucial roles in the upstream neuroinflammatory pathways. Thephosphorylation of Ser32 and 36 residues of IkB subunit leads to disruption of the bind between NF-kB complex [....] » Read More
Solid dispersion technology is the science of dispersing one or more active ingredients in an inert matrix in the solid stage to achieve an increased dissolution rate or sustained release of drug, altered solid state properties and improved stability. Fenofibrate (FNO), a pro-dru [....] » Read More
Streptococcus pneumoniae remains a primary cause of many diseases that leads to mortality worldwide. This study aimed to assess the effects of saponin encapsulated by ferritin nanoparticles on pulmonary changes induced by Streptococcus pneumoniae in NMRI mice. After fabrication a [....] » Read More
Microsponges drug delivery, because of their benefits has got a lot of potential and is very emerging field have been leading researchers around the globe to investigate them as drug carrier. Microsponges are polymeric drug delivery system composed of porous microspheres. T [....] » Read More
Title : Synergism in the permeability of the blood-brain barrier of heavy elements under the influence of electromagnetic fields.
Bartolome Ribas Ozonas, Royal National Academy of Pharmacy, Spain
The possible effects of electro magnetic fields (EMF) in the human body are explained because the external EMF, as a physic toxic agent, induced to a possible physiological and biochemical molecular effects as in the electron transfer chain in the mitochondria, synthesis by ATP-s [....] » Read More
Title : Rejuvenation of old drugs by repurposing, formulation and salt formation
Abraham Avi J Domb , The Hebrew University of Jerusalem, Israel
The introduction of a new drug entity to the clinic may take many years with a significant investment. Thus, only a few dozen of new drug entities are approved by the FDA each year. Chemical modification of existing drugs for improved properties or generating new IP, is considere [....] » Read More
Title : Pathology and Patient Safety: The vital role of electronic medical record and pathology informatics in error reduction and precision medicine
Consolato M Sergi, University of Ottawa, Canada
Electronic medical record (EMR)'s use has increased exponentially worldwide. The traditional pen and paper way to record events and data in a patient's chart has evolved to EMR, allowing numerous opportunities. There is the potential to provide higher quality and safer ca [....] » Read More
Title : Anti-inflammatory and Anti-oxidative Effects of Febuxostat on Periodontitis Rats Model
Naseratun Nessa, Kyoto Prefectural University of medicine, Japan
Objectives: Periodontal disease is quite prevalent and affects about 20-50% of global population. Periodontitis is a chronic inflammatory disease of the supporting structures of the teeth. When periodontal pathogens enter into the blood stream, such lifestyle diseases develop. Fe [....] » Read More
Title : Nano modification of Antrodia cinnamomea exhibit anti-inflammatory action and improves the migratory potential of myogenic progenitors
Mridula Prakash Menon, National Ilan University, Taiwan
Skeletal myogenesis involves the formation of new skeletal muscular tissue. During an injury, the skeletal muscle stem cells known as the satellite cells get activated and undergo proliferation, migration, and differentiation to complete the process of myogenesis. Muscle wasting [....] » Read More
Title : Dendrobium nobile Lindl. alkaloids-mediated protection against Aβ25-35-induced synaptic deficits is dependent on activation of Wnt/β-catenin pathway in rats and in cells
Wei Zhang, Guizhou University, China
Synaptic degeneration, associated mitochondrial dysfunction and accumulation of amyloid-β peptide are considered as the important manifestation which leads to cognitive impairment and memory loss in Alzheimer’s disease (AD)-affected brain. Avoiding the early characteri [....] » Read More
Title : Statistically Designed Terbinafine Hydrochloride Ethosomal Gel for Enhancement of Transdermal Delivery: In-silico Molecular docking, In vitro, Ex vivo and Stability Study
Hemalata Suhasrao Dol, Bharati Vidyapeeth College of Pharmacy, India
Terbinafine HCl (TH), an allylamine antifungal (BCS-II) drug has poor solubility and high permeability. In the present work, we have investigated the potential of ethosomes as vesicular lipid nanocarrier for enhancement of transdermal application of TH. The In-silico molecular do [....] » Read More
Title : Formulation and Evaluation of Biodegradable Polymeric Scaffolds containing Mupirocin Microspheres for Improved Wound Healing
Neha Manish Munot, Vishwakarma University, India
Development of a bio-composite using synergistic combination is a promising strategy to address various pathological manifestations of acute and chronic wounds. In the present work, we have combined three materials viz., mupirocin as an antimicrobial drug, mupirocin-chitosan micr [....] » Read More
Title : Polymeric Scaffold loaded with Polyphenolic Compound as Wound Dressings: A promising approach to wound healing
Shilpa Nilesh Shrotriya, Bharati Vidyapeeth University, India
Wounds are physical injuries which result in loss of the skin surface integrity. Proper healing of wound is essential for restoration of disturbed functions of skin. In the present research, we report fabrication of polyphenolic compound loaded nanofibrous scaffold as wound dress [....] » Read More
Title : Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein
Ruchika Bajaj, University of California, United States
P-glycoprotein (P-gp) plays a critical role in drug oral bioavailability and modulation of this transporter can alter the safety and/or e?cacy pro?le of substrate drugs. Individual oral molecular excipients that inhibit P-gp function have been considered as a mechanism for improv [....] » Read More
Title : Showcasing the Quality by Design Framework on Nano Drug Delivery Systems
Suryakanta Swain, The Assam Kaziranga University, India
The Quality by Design (QbD) approach empowers the researchers to minimize the number of experimental trials, errors and time during process of formulation development. It helps to identify the significant, influential factors such as critical material attributes, critical formula [....] » Read More
Title : revolution in nanotherapeutics for treatment and management of high grade glioblastoma Multiform
Aarti V Belgamwar, Institute of Pharmacutical Education and Research, India
Intracranial malignancies represent 1.4% of diagnosed cancers and Glioblastoma multiform (GBM) is one of the most aggressive malignant tumors with an overall dismal survival averaging one year despite multimodality therapeutic interventions including surgery, radiotherapy and con [....] » Read More
Title : Development And Optimization Of Nano-Emulsion Containing Rosemary Extract As Skin Rejuvenate Agent As A Novel Drug Delivery System
Devshree Gayakwad, Acropolis Institute of Pharmaceutical Education and Research, India
The effective delivery of Herbal drugs as a cosmetic formulation with the minimum side effects and better therapeutic efficacy has remained active area of research for many decades. This study aimed to developed and optimization oil in water (o/w) nano-emulsion containing r [....] » Read More
Title : Advanced multifunctional carbon dots/porphyrins for cancer diagnosis and photodynamic therapy
Gil Goncalves, University of Aveiro, Portugal
According to the findings of this study, a novel approach has been developed to address the constraints of employing porphyrins in photodynamic treatment, which include their low solubility and aggregation in biological contexts. The conjugation of porphyrins with graphene quantu [....] » Read More
Title : Phytochemical-based nanoformulation against Hepatocellular carcinoma
Lekshmi R Nath , AIMS Health Science Campus, India
Hepatocellular carcinoma (HCC) is one of the deadliest malignancies being the 3rd leading cause of cancer death worldwide. The current treatment of HCC fails to provide tumor specificity, causing many systemic toxicities and poor overall survival benefits especially for patients [....] » Read More
Title : All-trans retinoic acid loaded chitosan lipid nanocomplex for enhancing its diabetic nephropathy healing effect
Marwa Hasanein Mohamad Asfour, National Research Centre, Egypt
The present study aims to formulate all-trans retinoic acid (ATRA) loaded chitosan lipid nanocomplex (CHLNC) for enhancing its solubility and oral delivery. This is to improve ATRA therapeutic effect on diabetic nephropathy (DN). CHLNC was prepared by o/w homogenization, employin [....] » Read More
Title : Assessment of Marquesan Rauvolfia nukuhivensis bioactive content
Phila Raharivelomanana, University of French Polynesia, French Polynesia
Rauvolfia genus, grown in tropical areas, is well-known for its many species used in traditional medicine which healing properties inspired pharmacological studies leading to successful discovery of innovative drugs through years. Finding of these drugs were directly related to e [....] » Read More