The new EU GMP Annex 1 for sterile Manufacturing was published in August 2022. The industry does now have one year time for implementation. Exception loading and unloading for the Lyophilization which provides an implementation time of two years. What does this mean for sterile M [....] » Read More
The prevalence of diabetes and obesity is an increasing worldwide problem, and is referred to as the twin epidemics. In the physiological context, today we know that native glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are incretin hormone [....] » Read More
Ulcerative colitis (UC) is a continual, relapsing inflammatory illness that mainly involves from rectum to submucosa. Curcumin (Cur) has been reported as a credible phytochemical component with effective treatment activity against UC, but it is prone to degradation during the dig [....] » Read More
General and local anaesthetics are widely used during surgical interventions. These drugs have usually associated with mild and reversible local adverse drug reactions (ADRs), but also with more severe and systemic ADRs, including respiratory and cardiovascular depression and ana [....] » Read More
One of the novel advanced techniques established for enhancement of the dissolution rate and bioavailability, controlling or modifying drug release, taste masking, and stabilizing the active pharmaceutical ingredient (API) is Hot melt extrusion (HME). A combination of Drugs [....] » Read More
COVID‐19 has created a major threat to the human population across the globe. Since 2020, there are many mutations in SARS CoV-2 like Alpha, Beta, Delta and Omicron etc. Out of this Omicron variant is one of the fastest-spreading diseases in Covid-19. But still, we are no [....] » Read More
Background: Diabetes Mellitus (DM) has impacted 422 million people worldwide and is responsible for around 1.5 million fatalities. Drug utilisation studies and the quality of life of diabetes patients are critical disease management evaluation markers. Materials and Methods: 1 [....] » Read More
Background: During covid pandemic period our home restricted life led to many undesirable physical, physiological and mental alterations. Yoga a traditional system of medicines by virtue of its holistic approach towards health and disease and also due to reasonable cost, the [....] » Read More
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, several [....] » Read More
A carcinogen in any agent able to cause cancer in humans or animals increases cancer incidence or malignancy or shortens the latency period. A chemical is considered carcinogenic after being intensively studied by researchers and after one or more agencies evaluated the evidence [....] » Read More
All stakeholders involved in food production are becoming increasingly concerned about how animal production affects the health of people, animals, and the environment in a "One Health" approach. The ongoing use of pharmaceuticals in animals used for food production is [....] » Read More
The approach to hyponatremia is in a state of flux, especially in differentiating the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) from cerebral-renal salt wasting (RSW) because of diametrically opposite therapeutic goals of water-restricting in SIADH and a [....] » Read More
Since antient time human beings have been utilizing herbs as rich source of natural medicines. In the modern world, majority of the population trust allopathic medicines to treat most of the diseases without realizing that, plenty of the modern day’s medicines are also obta [....] » Read More
Butea monosperma (Family Fabaceae) popularly known as ‘dhak’ or ‘palas’, commonly known as ‘Flame of forest’ is an important plant and is extensively utilized for lac cultivation. Butea monosperma is found in countries like India, Bangladesh, N [....] » Read More
As an alternative to traditional needle injections, a number of non-invasive administrations have lately surfaced. The least unattractive approach among them is a transdermal drug delivery system (TDDS), which has a low rejection rate, excellent ease of administration, and outsta [....] » Read More
The present study focused on the formulation of mucoadhesive bilayer composite films for the treatment of periodontitis and the evaluation of its physicochemical properties. The primary layer was prepared by flaxseed and HPMC composite to sustain the release of doxycycline hyclat [....] » Read More
Nasopharyngeal carcinoma (NPC) is diverse cancer with no well-defined tumor antigen, associated with oncogenic Epstein-Barr Virus (EBV), and with usually late-stage diagnosis and survival <40%. Current radio- and chemotherapy have low effectiveness and cause adverse effects. I [....] » Read More
A specific HS-GC method has been developed, optimized, and validated for the determination of genotoxic impurity Bromoethane in Vigabatrin (VGB) drug substance. Chromatographic separation of genotoxic Bromoethane impurity was achieved on DB-1 column (30m × 0.53 mm, 5.0 μ [....] » Read More
Title : Extracellular vesicles as delivery vehicles of therapeutic compounds
Stefania Raimondo, University of Palermo, Italy
Extracellular vesicles (EVs) are lipoproteic particles released by organisms belonging to different kingdoms, and research in recent years has indicated they are mainly involved in cross-kingdom interaction. The content of EVs consists of various biomolecules, such as proteins, n [....] » Read More
Title : Role of nanoformulations in treating Cystic Fibrosis
Bhupendra Gopalbhai Prajapati, Shree S.K.Patel College of Pharmaceutical Education and Research, India
Cystic fibrosis is a genetic disease caused by CFTR gene mutations resulting in impaired mucociliary clearance and causing infection, inflammation, and insufficiently working respiratory system. This disease affects more than seventy thousand people across the globe. Multi-organ [....] » Read More
Title : Pathology and patient safety: The vital role of electronic medical record and pathology informatics in error reduction and precision medicine
Consolato M Sergi, University of Ottawa, Canada
Electronic medical record (EMR)'s use has increased exponentially worldwide. There is a large variety of laboratory information systems (LIS) in the modern healthcare, which may have remarkable advantages over the traditional pen and paper way to record events and data in a p [....] » Read More
Title : mRNA-based systemically delivered directed gene therapy using nanomaterials
A C Matin, Stanford University, United States
The presentation focuses on systemically administered targeted gene therapy using mRNA instead of DNA; why the former is superior for this purpose will be discussed. Lipid nanoparticles (LNPs) and, more recently, extracellular vesicles (EVs, aka exosomes) have proven effective ve [....] » Read More
Title : Mucoadhesive electrospun fibrous systems for the fast and sustained delivery of drugs
Luis Jesus Villarreal Gomez, Autonomous University of Baja California, Mexico
The necessity of new systems for drug delivery in children and specific procedures is clearly needed, in the case of children the difficulty of the correct dose administration is a problem when the drug carrier is not easy to administrate by a non-specialized adult. Mucoadhesive [....] » Read More
Title : 15,16-dihydrotanshinone-I-laden PLGA-co-PEG nanoparticles are potential therapeutic agents for the treatment of colorectal cancer by targeting the β-catenin/CD36 axis
Kwan Hiu Yee, Hong Kong Baptist University, China
15,16-dihydrotanshinone I (DHTS) is tanshinones, a class of lipophilic abietane diterpenes rich in Salvia miltiorrhiza Bunge. It has many pharmacological activities. However, the poor solubility and biocompatibility of DHTS have hindered its clinical application. To enhance the s [....] » Read More
Title : Evaluation of medicine implementation: Nursing habits
Saliha Koc Aslan, Acibadem Healthcare Group, Turkey
Objective: This work aims to examine nurse's medicine implementation Material and Method: This is a retrospective work. 10198 nurses who join the process of medicine implementation in a group hospital between the years of 2017-2020 generates. The number of nurses to be sam [....] » Read More
Title : Cytotoxic potential of culinary herbs
Jegathambigai R Naidu, Manipal University, Malaysia
Recent advances in our understanding of the cellular and molecular events of carcinogenesis have led to the development of a promising therapeutic strategy for the treatment and prevention of cancer. Chemoprevention can be defined as the use of substances of chemical (natural or [....] » Read More
Title : Intranasal delivery of Galanin receptor 2 and Neuropeptide Y1 receptor agonists enhances spatial memory and antidepressant effects in rats: Linking to hippocampal neurogenesis.
Manuel Narvaez Pelaez, University of Malaga, Spain
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases and depression, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for Neuropeptide Y (NPY) and galanin (GAL) inter [....] » Read More
Title : Patients’ access to essential Medicines at primary healthcare facilities: A crosssectional study in khartoum state, Sudan, 2022
Lina Abdelrahman Osman Hemmeda , University of Khartoum, Sudan
Access to free essential medicines is a critical component of universal health coverage. However, the availability of essential medicines in Sudan isn't well studied. As well, the majority of Sudanese people lack health insurance, making out-of-pocket sp ending the primary so [....] » Read More
Title : The study of antimicrobial activity of synthesized and natural-source chemical compounds by optical fluorescence respirometry using a Ru(II)-based oxygen-sensitive sensor
Katarzyna Turecka, Medical University of Gdansk, Poland
The determination of the number of microorganisms is very important a.o. in the field pharmacy, biotechnology or clinical microbiology. Studying the antimicrobial properties of natural or synthetic products requires testing many samples, against many bacteria or fungi in a short [....] » Read More
Title : Quality control of medicines and the role of quality control laboratory
Merita Kucuku, Freelance consultant, Albania
The role of the laboratory is very important for the quality control of medicines, especially for imported medicines. People very often discuss for the efficacy of medicines and this answer can give from the laboratory. Quality control of medicines has an impact on public health [....] » Read More
Title : Application of cactus pear (Opuntia ficus-indica l.) Cladodes in the formulation of an hand moisturizer creamIn this current study we are interested in the study of a part of the prickly pear (the cladodes) which constitute a by-product and can be exploited in many applications and are characterized by their effect on health and their richness in b
Fatiha Brahmi, University of Bejaia, Algeria
In this current study, we are interested in the study of a part of the prickly pear (the cladodes) which constitute a by-product and can be exploited in many applications and are characterized by their effect on health and their richness in bioactive compounds. Before formulating [....] » Read More
Title : Glandora rosmarinifolia essential oil: A potential natural anticancer agent
Manuela Labbozzetta, University of Palermo, Italy
Identifying, testing and implementing the use of new medicinal plants in current therapeutic protocols is a very complex, time-consuming and costly process. In many situations, the focus is on the study of plant extracts as it is known that in some cases the activity of the phyto [....] » Read More
Title : Separation and assay of sorbitol and sucralose binary mixture by extraction using HPLC/ELSD method
Miranda Fawzi Kamal Younis, Damanhour University, Egypt
An accurate, rapid and sensitive novel chromatographic method has been developed, validated and applied for the determination of Sucralose and Sorbitol; each compound in the presence of the other, in their binary mixtures. Isosweet ® artificial sweetener is a co-formula [....] » Read More
Title : Pediatric brain on cannabinoids: Adverse effects of cannabinoid products in children and adolescents
Peter B Chase, Essentia Health- St. Mary's Medical Center, United States
Cannabinoids (phytocannabinoids and synthetic cannabinoids) are most often used during adolescence and given the changing norms, enhanced potency, reduced societal perceptions of risk and multitude of forms of products for consumption, clinicians need to become more cognizant of [....] » Read More
Title : Gastroprotective effect of an aqueous extract of syzygium aromaticum (L.) Merr. & Perry (Myrtaceae) In wistar rats
Irie bi Jean severin, Felix Houphouet-Boigny University , Cote d'Ivoire
In Africa, 80% of the population uses medicinal plants for their primary health care. In Ivory Coast, Syzygium aromaticum (Myrtaceae) is used in traditional medicine in the treatment of gastric ulcers. This study aims to verify the gastroprotective effect of an aqueous extract of [....] » Read More
Title : Theranostic hyaluronan coated edta modified magnetic mesoporous silica nanoparticles for targeted delivery of cisplatin
Khatereh zarkesh, Hormozgan University of Medical Sciences, Iran (Islamic Republic of)
One of the eminent capabilities of nanoparticles in drug delivery is active targeting. Mesoporous silica nanoparticles (MSNs) are among the well-known nanocarriers, which have been utilized for gene and drug deliveries due to their particular physical and chemical properties.&nbs [....] » Read More
Title : Enhancing drug loading of Phenytoin into nanoemulsion via hydrophobic ion pairing and its potential to prevent in-vitro precipitation upon serial dilution at blood pH
Dimple Modi, GlaxoSmithKline, United States
Phenytoin was originally formulated in organic solvents at pH 12 and has been used via intravenous administration in treating epilepsy. However, due to its unfavorable pKa (8.3) with respect to physiological blood pH 7.4, it resulted in poor solubility and precipitation that caus [....] » Read More