Cystic fibrosis is a genetic disease caused by CFTR gene mutations resulting in impaired mucociliary clearance and causing infection, inflammation, and insufficiently working respiratory system. This disease affects more than seventy thousand people across the globe. Multi-organ [....] » Read More
Context and objectives: The treatment of chronic wounds is difficult and expensive. This situation is aggravated by the phenomenon of antibiotic resistance, a public health problem. It is linked to self-medication, non-rational use of conventional antibiotics and empirical use of [....] » Read More
Background: During covid pandemic period our home restricted life led to many undesirable physical, physiological and mental alterations. Yoga a traditional system of medicines by virtue of its holistic approach towards health and disease and also due to reasonable cost, the [....] » Read More
Recent advances in our understanding of the cellular and molecular events of carcinogenesis have led to the development of a promising therapeutic strategy for the treatment and prevention of cancer. Chemoprevention can be defined as the use of substances of chemical (natural or [....] » Read More
COVID‐19 has created a major threat to the human population across the globe. Since 2020, there are many mutations in SARS CoV-2 like Alpha, Beta, Delta and Omicron etc. Out of this Omicron variant is one of the fastest-spreading diseases in Covid-19. But still, we are no [....] » Read More
Mallotus philippinensis is widely distributed in outer Himalayan regions under the Euphorbiaceae family and are reported to have several pharmacological activities. It has been used as herbal medicine in India and the bark of the plant is used for several disorders like typhoid, [....] » Read More
The present study focused on the formulation of mucoadhesive bilayer composite films for the treatment of periodontitis and the evaluation of its physicochemical properties. The primary layer was prepared by flaxseed and HPMC composite to sustain the release of doxycycline hyclat [....] » Read More
Micoballoons of Olmesartan (OLM)were formulated by solvent diffusion method using HPMC, Eudragit and Ethyl Cellulose as rate-controlling polymers. The yield of Micoballoons up to 75.2 - 91.68% and shows good flow properties and on the basis of optical microscopy for prepared Mico [....] » Read More
Breast cancer metastasis is a serious cause of morbidity and mortality in females globally. Metastatic cells show immune evasion, drug resistance and relapse and frequently differ from the preceding primary breast cancer in properties. Several biological processes, including tumo [....] » Read More
Despite the availability of sufficient data on the effects of individual metal exposure on living organisms, a critical knowledge gap still exists in predicting effects of multi-metals particularly on the pituitary-testicular axis. Thus, the aim of the present study was to check [....] » Read More
Access to free essential medicines is a critical component of universal health coverage. However, the availability of essential medicines in Sudan isn't well studied. As well, the majority of Sudanese people lack health insurance, making out-of-pocket sp ending the primary so [....] » Read More
A carcinogen in any agent able to cause cancer in humans or animals increases cancer incidence or malignancy or shortens the latency period. A chemical is considered carcinogenic after being intensively studied by researchers and after one or more agencies evaluated the evidence [....] » Read More
Cannabinoids (phytocannabinoids and synthetic cannabinoids) are most often used during adolescence and given the changing norms, enhanced potency, reduced societal perceptions of risk and multitude of forms of products for consumption, clinicians need to become more cognizant of [....] » Read More
One of the novel advanced techniques established for enhancement of the dissolution rate and bioavailability, controlling or modifying drug release, taste masking, and stabilizing the active pharmaceutical ingredient (API) is Hot melt extrusion (HME). A combination of Drugs [....] » Read More
The prices of patented pharmaceutical drugs like Afifon became a public concern and politicians all over the world discussed this matter. These prices are causing concern to Health Funds whose budget did not increase according to the prices of drugs. We look at the strategy of Is [....] » Read More
The COVID-19 pandemic continues to be a big threat to the world, this pandemic has had a profound impact on the health, social, and economic situation of the world. One of the biggest challenges of this pandemic is to deal with the continuity of pharmaceutical manufacturing & [....] » Read More
While the treatments for the respiratory disease vary, the efficacy of drugs is frequently limited by their inability to reach the target site of action. One of the largest limitations underlying current treatment methodologies is the inability for therapeutics to discriminate be [....] » Read More
Sickle Cell Anemia (SCA), also called Sickle Cell Disease (SCD), is an inherited hematological disorder characterized by a syndrome of acute anemia and a painful crisis. The sickling hemoglobin, Hgb-S caus- es viscosity and inflammation of blood vessels. Eventually, the red blood [....] » Read More
Title : mRNA-based systemically delivered directed gene therapy using nanomaterials
A C Matin, Stanford University, United States
The presentation focuses on systemically administered targeted gene therapy using mRNA instead of DNA; why the former is superior for this purpose will be discussed. Lipid nanoparticles (LNPs) and, more recently, extracellular vesicles (EVs, aka exosomes) have proven effective ve [....] » Read More
Title : Pro and con to dermpharm and tox assays- 2023
Howard I Maibach, University of California, United States
In the days before World War 2, Dr. Draize at FDA conceptualized models predictive of potential for skin irritation and allergic contact dermatitis potential that with modifications based on newer experimental data have stood the test of time and remain efficient to today. The in [....] » Read More
Title : Mucoadhesive electrospun fibrous systems for the fast and sustained delivery of drugs
Luis Jesus Villarreal Gomez, Autonomous University of Baja California, Mexico
The necessity of new systems for drug delivery in children and specific procedures is clearly needed, in the case of children the difficulty of the correct dose administration is a problem when the drug carrier is not easy to administrate by a non-specialized adult. Mucoadhesive [....] » Read More
Title : Pathology and patient safety: The vital role of electronic medical record and pathology informatics in error reduction and precision medicine
Consolato M Sergi, University of Ottawa, Canada
Electronic medical record (EMR)'s use has increased exponentially worldwide. There is a large variety of laboratory information systems (LIS) in the modern healthcare, which may have remarkable advantages over the traditional pen and paper way to record events and data in a p [....] » Read More
Title : EU GMP annex1 barrier system and PIC/s annex 2A on cell and gene therapy
Richard Denk, SKAN AG, Switzerland
The new EU GMP Annex 1 for sterile Manufacturing was published in August 2022. The industry does now have one year time for implementation. Exception loading and unloading for the Lyophilization which provides an implementation time of two years. What does this mean for sterile M [....] » Read More
Title : Extracellular vesicles as delivery vehicles of therapeutic compounds
Stefania Raimondo, University of Palermo, Italy
Extracellular vesicles (EVs) are lipoproteic particles released by organisms belonging to different kingdoms, and research in recent years has indicated they are mainly involved in cross-kingdom interaction. The content of EVs consists of various biomolecules, such as proteins, n [....] » Read More
Title : Dual GIP/GLP-1 receptor stimulation in treatment of type 2 diabetes mellitus – The ground-breaking 'twincretin' approach
Miroslav Radenkovic, University of Belgrade, Serbia
The prevalence of diabetes and obesity is an increasing worldwide problem, and is referred to as the twin epidemics. In the physiological context, today we know that native glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are incretin hormone [....] » Read More
Title : Development and validation of quantitative analysis using head space gas chromatographic method [HS-GC] of genotoxic impurity bromoethane in vigabatrin drug substance
Narapereddy Krishna Prasad, Reckitt Benckiser LLC, United States
A specific HS-GC method has been developed, optimized, and validated for the determination of genotoxic impurity Bromoethane in Vigabatrin (VGB) drug substance. Chromatographic separation of genotoxic Bromoethane impurity was achieved on DB-1 column (30m × 0.53 mm, 5.0 μ [....] » Read More
Title : Quality control of medicines and the role of quality control laboratory
Merita Kucuku, Freelance consultant, Albania
The role of the laboratory is very important for the quality control of medicines, especially for imported medicines. People very often discuss for the efficacy of medicines and this answer can give from the laboratory. Quality control of medicines has an impact on public health [....] » Read More
Title : Evaluation of medicine implementation: Nursing habits
Saliha Koc Aslan, Acibadem Healthcare Group, Turkey
Objective: This work aims to examine nurse's medicine implementation Material and Method: This is a retrospective work. 10198 nurses who join the process of medicine implementation in a group hospital between the years of 2017-2020 generates. The number of nurses to be sam [....] » Read More
Title : 15,16-dihydrotanshinone-I-laden PLGA-co-PEG nanoparticles are potential therapeutic agents for the treatment of colorectal cancer by targeting the β-catenin/CD36 axis
Kwan Hiu Yee, Hong Kong Baptist University, China
15,16-dihydrotanshinone I (DHTS) is tanshinones, a class of lipophilic abietane diterpenes rich in Salvia miltiorrhiza Bunge. It has many pharmacological activities. However, the poor solubility and biocompatibility of DHTS have hindered its clinical application. To enhance th [....] » Read More
Title : Genetic association between mild Osteogenesis Imperfecta(OI) and postmenopausal osteoporosis
Eiman Mohammad Shahrour, Tishreen University, Syrian Arab Republic
Background: Mild osteogenesis imperfecta OI and postmenopausal osteoporosis are both bone disorders. Mild OI may be associated with postmenopausal osteoporosis. According to NCBI, COL1A2rs72658152 (COL1A2G661S) is a pathogenic proven cause of the association between mild OI and p [....] » Read More
Title : Thiadiazine-2-thione derivatives as new cell- cycle inhibitors
Tarek Aboul Fadl, Assiut University, Egypt
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, several [....] » Read More
Title : Intranasal delivery of Galanin receptor 2 and Neuropeptide Y1 receptor agonists enhances spatial memory and antidepressant effects in rats: Linking to hippocampal neurogenesis.
Manuel Narvaez Pelaez, University of Malaga, Spain
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases and depression, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for Neuropeptide Y (NPY) and galanin (GAL) inter [....] » Read More
Title : EBV latent membrane protein 1 augments gammer-delta T cell cytotoxicity against nasopharyngeal carcinoma by induction of butyrophilin molecules
Yue liu, Hong Kong Baptist University, China
Nasopharyngeal carcinoma (NPC) is diverse cancer with no well-defined tumor antigen, associated with oncogenic Epstein-Barr Virus (EBV), and with usually late-stage diagnosis and survival <40%. Current radio- and chemotherapy have low effectiveness and cause adverse effects. I [....] » Read More