HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.
Siraj Khan, Speaker at Pharma Conferences
Qarshi Industries, Pakistan
Title : Innovative approaches in novel drug delivery systems: Enhancing efficacy and targeted therapy

Abstract:

The development of novel drug delivery systems (NDDS) represents a transformative advancement in pharmaceutical sciences, aimed at enhancing the precision, efficiency, and safety of therapeutic interventions. This research explores state-of-the-art NDDS, including nanoparticle-based systems, liposomal encapsulation, and polymeric carriers, which are designed to optimize drug bioavailability, control release rates, and target specific tissues or cells. Our lab conducted extensive in vitro and in vivo studies on these systems, demonstrating significant improvements in therapeutic outcomes. For instance, nanoparticle-based delivery of anti-cancer drugs resulted in a 50% increase in tumor reduction compared to conventional methods, while liposomal encapsulation of antibiotics showed a 70% decrease in bacterial load with reduced systemic toxicity. The research methodology involved synthesizing nanoparticles using biodegradable polymers and characterizing their size, surface charge, and drug-loading efficiency. These nanoparticles were then tested on cancer cell lines to assess their cytotoxicity and uptake efficiency. The in vivo studies involved animal models where the biodistribution, pharmacokinetics, and therapeutic efficacy of the drug-loaded nanoparticles were evaluated. The results indicated that the nanoparticles provided a sustained release of the drug, resulting in prolonged circulation time and enhanced accumulation in the tumor tissue, thereby improving the therapeutic index of the anti-cancer drugs. Similarly, liposomal encapsulation of antibiotics was explored to address the challenge of multidrug-resistant bacterial infections. The liposomes were formulated to enhance the stability and bioavailability of the antibiotics, reducing the required dosage and minimizing adverse effects. In vitro assays demonstrated a significant increase in antibacterial activity, while in vivo studies in infected animal models showed a marked reduction in bacterial load and improved survival rates. This study also delves into the challenges of translating these innovative drug delivery systems from the laboratory to clinical settings. Issues such as large-scale manufacturing, stability, regulatory approval, and cost-effectiveness are discussed. The potential for NDDS to facilitate personalized medicine is also highlighted, where treatments can be tailored to individual patient profiles for optimal efficacy and minimal side effects. The findings of this research underscore the critical role of innovative drug delivery technologies in the evolution of modern therapeutics. By enhancing the delivery and efficacy of drugs, NDDS hold the promise to revolutionize patient care, offering new hope for the treatment of various diseases, particularly those with limited therapeutic options. Future research should focus on overcoming the translational challenges and further optimizing these systems for widespread clinical use.

Keywords: Novel Drug Delivery Systems, Nanoparticle-Based Delivery, Targeted Therapy, Bioavailability, Therapeutic Efficacy

Audience Take Away Notes:
Attendees will gain a comprehensive understanding of novel drug delivery systems (NDDS), such as nanoparticle-based systems and liposomal encapsulation, which they can apply in pharmaceutical development to design more effective and safer drug delivery mechanisms. The presentation will provide practical methodologies for synthesizing and characterizing these systems, streamlining laboratory workflows and enhancing research efficiency. This knowledge will be valuable for researchers and faculty looking to expand their studies or integrate advanced drug delivery concepts into their teaching. Additionally, the insights will help pharmaceutical scientists develop more accurate and efficient drug formulations, addressing common challenges like poor solubility and stability, ultimately leading to innovative solutions in drug development and improved patient care

Biography:

Siraj Khan has been honored with the prestigious title of International Best Researcher at the International Congress for Research Excellence 2024. He holds a Doctoral and MS degree in Plant Sciences from Quaid-i-Azam University Islamabad, Pakistan. Dr. Khan's extensive academic and professional journey includes serving as a Senior Scientific Officer at Qarshi Herb Research Center and Qarshi University, within Qarshi Herbal Industries (Pvt.) Ltd in Hattar, Haripur, Pakistan. His expertise spans various laboratory techniques, such as Light and Scanning Electron Microscopy, HPLC, GCMS, LCMS, CC, TLC, NMR, and Spectrophotometry. Additionally, he is proficient in microbiology, phytoremediation, DNA and RNA extraction, PCR, Gel electrophoresis, landscape management, orchid management, herbarium techniques, and digitalization. Dr. Khan has made significant contributions to plant systematics, taxonomy, plant physiology, and evolution, with a focus on exploring the medicinal properties of herbs. He has published 20 research articles and actively participated in 33 international conferences and workshops. He has also organized 22 conferences, demonstrating his leadership and organizational skills within the academic community. His accolades include memberships in esteemed organizations such as the Royal Microscopical Society and the American Society for Microbiology, and he serves as a permanent reviewer for journals like "Plant Science Today" and "Microscopy Research and Technique."In addition to his academic achievements, Dr. Khan has received awards such as the Merit Scholarship during his MPhil at Quaid-i-Azam University and a certificate of excellence as the best reviewer for "Chemical Science International Journal" in 2020. His research on the medicinal properties of herbs, particularly in combating cancer, and his expertise in phytoremediation, highlight his contributions to healthcare and environmental sustainability. Dr. Khan's dedication to botanical sciences and his pursuit of excellence have earned him international recognition as an exemplary researcher, making a significant impact on both academia and broader human well-being.

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