Title : Mesenchymal stem cell–derived exosomes in neurological disorders
Abstract:
Exosomes are released by hematopoietic and non-hematopoietic stem cell origin. With ever-increasing developments of MSCs-Exo research,several research achievements have been made on the potential mechanism of MSCs-Exo and therapeutic effect in a variety of Neurological diseases, showing great potential for Neuromuscular regeneration. Not only the treatment-related research of MSCs-Exo is still in the early stage, but also there are many research gaps and problems should be explored and solved. First of all, exosome bioactivity must be detected precisely. Only when exosomes have biological activity can they show function for diagnosing or treating neurologic diseases. The next one, for exosomes biodistribution, in vivo tracking and targeting should be monitored. The most important gap is exosomes composition standardizations, therefore sharing the clinical experiment could fill this gap about using dose, source production and so on. This presentation includes an unbelievable muscle power improvement in two cases in the first week after exosome injection .These observations suggest cell-signaling improvement may induce neuroplasticity and neurorehabilitation.
