We performed ,in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and Axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases.Some years later,&nbs [....] » Read More
The management of complex wounds is a huge challenge. It is associated with necrosis, infections and tissue losses. It need intense care and substantial cost. These cares include surgical and pharmaceutical interventions associated with risks, side effects and morbidity. The e [....] » Read More
OUTLINE Discuss the history and properties of MSCs Discuss rationale for use of uMSC in COVID-19 Present institutional Protocol for use of uMSC in COVID-19 pneumonia Present local experience and outcome of patients treated with uMSC with COVID-19 Key [....] » Read More
The world advancing rapidly in the field of technology, a simple example is our mobile phone. However, when compared to healthcare, the diagnostic and treatment of diseases are still very poor and surgery has not changed significantly compared with 50 years ago. There is plenty o [....] » Read More
Developed a Rapid Parallel Search (RPS) technology shows keys to preventing the spread of virus outbreaks by exactly and quickly identify sick and asymptomatic carriers. RPS uses the time-tested Scanning Electron Microscopy (SEM) and Artificial Neural Network (ANN) methods for de [....] » Read More
α-Synucleinopathies is characterized with accumulation of misfolded α-synuclein (α-syn), including Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB), and Multiple System Atrophy (MSA). Emerging evidence indicates that pathogenesis of α-synucl [....] » Read More
Cell fate determination induced by cell signaling is central to stem cells and regenerative medicine. Pluripotent stem cells such as embryonic stem cells (ESC) are an attractive model for understanding the relationship between cell signaling and cell fates. Cultured mouse ESCs ar [....] » Read More
The peripheral nervous system consists of glial cells and neurons that receive the necessary chemical, physical, and mechanical stimuli for their adhesion, proliferation, and differentiation from their extracellular milieu. Mechanotransduction refers to the ability of a cell to [....] » Read More
Placental extract formulation Regenerin (Patent no- RU 2469704 CI, dt: 07.07.2011) has been reported to possess antioxidant, antimicrobial, anti-inflammatory, cellular proliferation, and tissue regeneration properties. Considering the properties of placental extract, the present [....] » Read More
Poorly functioning scaffold materials and limitations in material-cell construction technology remain problems in bone tissue engineering. Electrospinning has been proven to be a suitable and available technique for production of 3D biomimetic scaffolds. To overcome these problem [....] » Read More
Exosomes are released by hematopoietic and non-hematopoietic stem cell origin. With ever-increasing developments of MSCs-Exo research,several research achievements have been made on the potential mechanism of MSCs-Exo and therapeutic effect in a variety of Neurological diseases, [....] » Read More
The potential of thermomechanical effect of pulsed-periodic mid-IR laser radiation for the stimulation of tissue self-restoration and for implant modeling is discussed. The principle underlying the effect includes thermal and mechanical components when radiation is absorbed by in [....] » Read More
Introduction: Skeletal muscle injury is a common clinical challenge. It is usually associated with fibrosis and disability. Regenerative medicine is an emerging promising strategy that could improve such cases. However, it is not clear if stem cells have beneficial long-term effe [....] » Read More
Background: The benefits gained by improved RBCs component quality should more than justify any real or perceived inconvenience to the blood services in implementing adjustments to their processing procedures or additional processing costs of the introduction of new generation RB [....] » Read More
Chitosan a deacetylation derivative of chitin, has several applications in biomedical and healthcare research as a result of being abundant in nature and its unique physicochemical properties such as biocompatibility and biodegradability. Functionalising chitosan improves its pro [....] » Read More
Osteoporosis is a disorder characterized by bone mass loss due to reduced calcium absorption. The menopause stage induces downregulation of calcium absorption in the intestine which caused low estrogen levels. One of the sources of estrogen could be phytoestrogen from Tofu. Exoge [....] » Read More
Advanced cell culture technologies and especially three-dimensional (3D) cell cultivation combined with modern biotechnological methods are increasingly applied to regenerate damaged and diseased tissue, such as skin, cartilage or bones. In order to monitor and follow 3D cell cu [....] » Read More
Title : Electroactive polymer-based smart scaffolds for tissue engineering and regenerative medicine
Federico Carpi, University of Florence, Italy
Cellular scaffolds are a critical component of any system for tissue engineering and regenerative medicine. So far, poor attention has been focused on scaffolds that can mimic the extracellular matrix not only statically, but also dynamically, especially for tissues that have to [....] » Read More
Title : Open abdomen and negative pressure wound therapy for acute peritonitis especially in the presence of anastomoses and ostomies
Orestis Ioannidis, Aristotle University of Thessaloniki, Greece
Acute peritonitis is a relatively common intra-abdominal infection that a general surgeon will have to manage many times in his surgical carrier. Usually it is a secondary peritonitis caused either by direct peritoneal invasion from an inflamed infected viscera or by gastrointest [....] » Read More
Title : Mechanical modulation of cell response in 3D bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
The fabrication of human tissues and organs exhibiting structural, mechanical and biological function remains a major challenge due to their structural complexity, multicellular composition, spatial heterogeneity of the ECM and, in most cases, the presence of a vascular network. [....] » Read More
Title : Patenting bioprinting innovations: An australian perspective
Pratap Devarapalli, University of Tasmania, Australia
Three-dimensional (3D) Bioprinting also known as 3D biofabrication is an additive manufacturing process that involves printing of biological material in the form of 3D structures such as tissues, scaffolds and organs. The applications of 3D Bioprinting range from personalized 3D [....] » Read More
Title : Clinical application and value of a new type of double-layer artificial dermis in the treatment of skin and soft tissue defects at the tip of fingers and toes
Haidong Liang, The Second Affiliated Hospital of Dalian Medical University, China
Finger tip skin and soft tissue defect is one of the most common hand injuries. Although many professional literatures have introduced and described its surgical treatment methods in detail,.treatment methods can not be widely developed because of their high requirements on micro [....] » Read More
Title : Transcriptional elements in the MMP13 gene: Can we target it in osteoarthritis?
Sara Ibrahim AlSalhi, University of Liverpool, United Kingdom
MMP13 is a primary catabolic factor involved in cartilage degradation through its ability to cleave type II collagen. Transcriptionally, MMP13 is regulated by 2 main elements; proximal promoter and distal enhancers. The aim of the study is to identify transcriptional elements tha [....] » Read More
Title : Cellular Mechanism in support of perinatal Amnion Epithelial Stem Cell Transplantation without Immunosuppression
Roberto Gramignoli, Karolinska Institutet, Sweden
The full-term placenta is a non-controversial and readily available source of stem cells for regenerative medicine. Our group was the first to isolate and validate regenerative effects offered by human amnion epithelial cells (hAEC), correcting congenital metabolic disorders. In [....] » Read More
Title : Design of 3D bioengineered personalized scaffolds to potentiate bone ingrowth and angiogenic network for oral tissues reconstruction
Christiane Salgado, Institute of Research and Innovation in Health(i3S), Brazil
Population ageing (>70 years) and associated risk factors (alcohol addiction and smoke - 85%) increase the number of oral cancer (more frequently, head and neck squamous cell carcinoma - HNSCC) cases requiring large bone defects repair, raising the need for bone and oral mucos [....] » Read More
Title : Biomimetic 3D bioprinted scaffold for sutureless corneal regeneration
Neha Ashok Waghmare, Pandorum Technologies Pvt. Ltd, India
Cornea is the first transmitting layer of the eye, responsible for 75% of its refractive power. Damage to the cornea can cause blindness, which affects over 12 million people worldwide. While corneal transplant remains the sole treatment option to restore vision in many severe ca [....] » Read More
Title : Bioactive snail mucus promotes cell attachment and mechanical properties of porous agarose 3D scaffold for tissue engineering applications
Victor A, Indian Institute of Science, India
Snail mucin, obtained from snails, is a complex substance that has been recounted to contain glycosaminoglycans (GaGs), allantoin, hyaluronic acid, elastin, and glycolic acid. Some of these constituents, especially GaGs, are essential for reducing cartilage deterioration and infl [....] » Read More
Title : In situ regeneration needs to establish a precise cellular microenvironment to restore renal function
Shrikant L Kulkarni, Kulkarni Clinic, India
As the patients with diabetes and obesity continue to grow, the trend of increasing prevalence of ckd will not to end. The current therapeutic option for ckd is ineffective. In spite of having, adequate reserve of cells and mechanism to repair the damaged tissue is replaced by fu [....] » Read More
Title : Predicting performance of nanofibrous scaffolds for skin tissue engineering: Deep learning compared to machine learning regression models
Dina Ahmed Salem, Misr University for Science and Technology, Egypt
On a medical side, lot of attention is directed nowadays to the field of Tissue Engineering and Regenerative Medicine. Skin Tissue Engineering provides a significant improvement to wounds healing with a remarkable effect on scars formation. Skin components can be rebuilt with saf [....] » Read More
Title : Smart hydrogel films for wound monitoring and healing
Diana Stan, Titu Maiorescu University, Romania
It is estimated that up to 2% of the population in developed countries will suffer from a chronic wound in their lifetime. This number will most likely increase due to the fact that the life expectancy increases and the world population with chronic diseases, such as diabetes and [....] » Read More
Title : Therapeutic applications of mesenchymal stromal cells in COVID-19: Promising evidence from in vitro results.
Panagiotis Mallis, Biomedical Research Foundation Academy of Athens, Greece
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic, which was initiated in December 2019. COVID-19 is characterized by a low mortality rate (< 6%); however, this percentage is higher [....] » Read More
Title : Tissue Engineering Approach to Decrease Complications after Surgical Treatment of Pressure Injuries in Spinal Cord Injured Patients
Alessandro Bertolo , Swiss Paraplegic Research, Switzerland
Pressure injuries (PI) are chronic wounds caused by increased pressure over a prolonged period of time. Interruption of blood circulation leads to a shortage of oxygen, nutrient supplies, accumulation of toxic by-products and tissue necrosis. Patients with spinal cord injury (SCI [....] » Read More
Title : Recellularized organs as ex vivo models for colorectal cancer metastasis
Onwuegbuchulam Olachi Angelica, University Hospital Muenster Germany, Germany
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. The main factor leading to mortality is the development of metastasis, mostly occurring in the liver. Reasons why the liver is the main metastatic site for CRC and which factors lead to inv [....] » Read More
Title : RADA16-I based scaffolds for wound healing and regenerative medicine
Deptula Milena, Medical University of Gdansk, Poland
In regenerative medicine there is a strong need for therapeutic delivery systems and tissue scaffolds. Additionally, wound healing complications affect thousands of people each year. The biggest problem constitute chronic wounds, e.g. diabetic ulcers. Currently available methods [....] » Read More
Title : Hydrogels reinforced with TiO2-NPs for wound healing application
Adnan Alizadeh Naini, Shiraz University, Iran (Islamic Republic of)
Full-thickness wounds are a growing problem due to their high costs and complications. Despite recent advances in wound healing, several systemic and local factors can impair the physiological healing process. This article briefly examines the role of titanium dioxide nanoparticl [....] » Read More
Title : Electrical stimulation in nerve tissue engineering. Multifactorial analysis in vitro
Yusser Olguin, Federico Santa Maria Technical University, Chile
Electrical stimulation in nerve tissue engineering is a way to promote cell differentiation, which experimentally demonstrates efficiency and characteristics dependent on the form of stimulation. Considering that the materials used to develop scaffolds usually incorporate chemica [....] » Read More