Small activating RNAs (saRNA) are double stranded 21 nucleotide RNA that either target promoters or enhance genes leading to mRNA upregulation. saRNAs can be delivered with liposomes into the systemic circulation or subcutaneously by conjugation with aptamers or GalNAC. MTL-CEBPA [....]
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The fabrication of human tissues and organs exhibiting structural, mechanical and biological function remains a major challenge due to their structural complexity, multicellular composition, spatial heterogeneity of the ECM and, in most cases, the presence of a vascular network. [....]
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Cellular scaffolds are a critical component of any system for tissue engineering and regenerative medicine. So far, poor attention has been focused on scaffolds that can mimic the extracellular matrix not only statically, but also dynamically, especially for tissues that have to [....]
» Read More
Acute peritonitis is a relatively common intra-abdominal infection that a general surgeon will have to manage many times in his surgical carrier. Usually it is a secondary peritonitis caused either by direct peritoneal invasion from an inflamed infected viscera or by gastrointest [....]
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Christiane Salgado , Institute of Research and Innovation in Health(i3S), Brazil
Population ageing (>70 years) and associated risk factors (alcohol addiction and smoke - 85%) increase the number of oral cancer (more frequently, head and neck squamous cell carcinoma - HNSCC) cases requiring large bone defects repair, raising the need for bone and oral mucos [....]
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Traditional 2D flat cell cultures of cancer cells and in vivo animal experiments remain the most commonly used techniques as in vitro and in vivo platforms for cancer research, drug screening and toxicity tests prior to entering human clinical trials. This is due to their low cos [....]
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Cells can migrate individually between tissues and organs or collectively in tightly or loosely associated groups. In both cases, cell migration is regulated by extracellular cues of very different natures. Here I will describe a cellular mechanism called curvotaxis that enables& [....]
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Electrical conductivity plays a crucial role in a wide range of biological applications including biosensors, drug delivery, and in particular tissue engineering. In tissue engineering towards the regeneration of tissues, such as nerves, cardiac, and muscles, electrical conductiv [....]
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Snail mucin, obtained from snails, is a complex substance that has been recounted to contain glycosaminoglycans (GaGs), allantoin, hyaluronic acid, elastin, and glycolic acid. Some of these constituents, especially GaGs, are essential for reducing cartilage deterioration and infl [....]
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In regenerative medicine there is a strong need for therapeutic delivery systems and tissue scaffolds. Additionally, wound healing complications affect thousands of people each year. The biggest problem constitute chronic wounds, e.g. diabetic ulcers. Currently available methods [....]
» Read More
Pressure injuries (PI) are chronic wounds caused by increased pressure over a prolonged period of time. Interruption of blood circulation leads to a shortage of oxygen, nutrient supplies, accumulation of toxic by-products and tissue necrosis. Patients with spinal cord injury (SCI [....]
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Fibrinogen is an attractive candidate for a wide range of regenerative treatments due to its bioactivity and FDA-approval.
Aim: We therefore sought to modify fibrinogen through covalent attachment of heparin. Heparin is desirable as it binds a significant number of growth fact [....]
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Sara Darakhshan, Kermanshah University of Medical Sciences, Iran (Islamic Republic of)
Uncontrolled bleeding is the primary reason for death in traumatic conditions and surgeries. Excessive bleeding causes a loss of hemodynamics, which leads to the need to receive blood, prolongs surgery time, and imposes significant costs on the health system. Therefore, using saf [....]
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Title : Small activating RNA from concept to phase 2 clinical trials
Nagy Habib, MiNA Therapeutics Ltd, United Kingdom
Small activating RNAs (saRNA) are double stranded 21 nucleotide RNA that either target promoters or enhance genes leading to mRNA upregulation. saRNAs can be delivered with liposomes into the systemic circulation or subcutaneously by conjugation with aptamers or GalNAC. MTL-CEBPA [....] » Read More
Title : Mechanical modulation of cell response in 3D bioprinted hydrogels
Ruben F Pereira, University of Porto, Portugal
The fabrication of human tissues and organs exhibiting structural, mechanical and biological function remains a major challenge due to their structural complexity, multicellular composition, spatial heterogeneity of the ECM and, in most cases, the presence of a vascular network. [....] » Read More
Title : Electroactive polymer-based smart scaffolds for tissue engineering and regenerative medicine
Federico Carpi, University of Florence, Italy
Cellular scaffolds are a critical component of any system for tissue engineering and regenerative medicine. So far, poor attention has been focused on scaffolds that can mimic the extracellular matrix not only statically, but also dynamically, especially for tissues that have to [....] » Read More
Title : Open abdomen and negative pressure wound therapy for acute peritonitis especially in the presence of anastomoses and ostomies
Orestis Ioannidis, Aristotle University of Thessaloniki, Greece
Acute peritonitis is a relatively common intra-abdominal infection that a general surgeon will have to manage many times in his surgical carrier. Usually it is a secondary peritonitis caused either by direct peritoneal invasion from an inflamed infected viscera or by gastrointest [....] » Read More
Title : Design of 3D bioengineered personalized scaffolds to potentiate bone ingrowth and angiogenic network for oral tissues reconstruction
Christiane Salgado , Institute of Research and Innovation in Health(i3S), Brazil
Population ageing (>70 years) and associated risk factors (alcohol addiction and smoke - 85%) increase the number of oral cancer (more frequently, head and neck squamous cell carcinoma - HNSCC) cases requiring large bone defects repair, raising the need for bone and oral mucos [....] » Read More
Title : High-throughput in vitro analysis of engineered tumour microenvironments using 3D bioprinting
Panthipa Suwannakot , UNSW Sydney, Australia
Traditional 2D flat cell cultures of cancer cells and in vivo animal experiments remain the most commonly used techniques as in vitro and in vivo platforms for cancer research, drug screening and toxicity tests prior to entering human clinical trials. This is due to their low cos [....] » Read More
Title : Curvotaxis mechanism in single cells and epithelia
Laurent Pieuchot, Universite de Haute-Alsace, France
Cells can migrate individually between tissues and organs or collectively in tightly or loosely associated groups. In both cases, cell migration is regulated by extracellular cues of very different natures. Here I will describe a cellular mechanism called curvotaxis that enables& [....] » Read More
Title : Biocompatible and highly conductive aqueous-based 3D printable inks for tissue engineering applications
Aida Naseri, University of Wollongong, Australia
Electrical conductivity plays a crucial role in a wide range of biological applications including biosensors, drug delivery, and in particular tissue engineering. In tissue engineering towards the regeneration of tissues, such as nerves, cardiac, and muscles, electrical conductiv [....] » Read More
Title : Cytokine Profiling in Cultured Endometrial Cells after Hormonal Treatment
Mark Gavriel, Tel Aviv University, Israel
Will be Updated Soon...
Title : Bioactive Snail Mucus Promotes Cell Attachment and Mechanical Properties of Porous Agarose 3D Scaffold for Tissue Engineering Applications
Ajisafe Victor Ayobami, Indian Institute of Science, India
Snail mucin, obtained from snails, is a complex substance that has been recounted to contain glycosaminoglycans (GaGs), allantoin, hyaluronic acid, elastin, and glycolic acid. Some of these constituents, especially GaGs, are essential for reducing cartilage deterioration and infl [....] » Read More
Title : RADA16-I based scaffolds for wound healing and regenerative medicine
Deptula Milena, Medical University of Gdansk, Poland
In regenerative medicine there is a strong need for therapeutic delivery systems and tissue scaffolds. Additionally, wound healing complications affect thousands of people each year. The biggest problem constitute chronic wounds, e.g. diabetic ulcers. Currently available methods [....] » Read More
Title : Tissue Engineering Approach to Decrease Complications after Surgical Treatment of Pressure Injuries in Spinal Cord Injured Patients
Alessandro Bertolo , Swiss Paraplegic Research, Switzerland
Pressure injuries (PI) are chronic wounds caused by increased pressure over a prolonged period of time. Interruption of blood circulation leads to a shortage of oxygen, nutrient supplies, accumulation of toxic by-products and tissue necrosis. Patients with spinal cord injury (SCI [....] » Read More
Title : Heparin conjugated fibrin as a delivery vehicle for regenerative medicine
Silindile Ngcobo, University of Cape Town, South Africa
Fibrinogen is an attractive candidate for a wide range of regenerative treatments due to its bioactivity and FDA-approval. Aim: We therefore sought to modify fibrinogen through covalent attachment of heparin. Heparin is desirable as it binds a significant number of growth fact [....] » Read More
Title : Hemostatic polyurethane sponge containing kaolin, tannic acid and tranexamic acid
Sara Darakhshan, Kermanshah University of Medical Sciences, Iran (Islamic Republic of)
Uncontrolled bleeding is the primary reason for death in traumatic conditions and surgeries. Excessive bleeding causes a loss of hemodynamics, which leads to the need to receive blood, prolongs surgery time, and imposes significant costs on the health system. Therefore, using saf [....] » Read More