Title : Normal cellular differentiation without reprogramming pluripotent factors and banking cancer stem cells: A new era in regenerative medicine
Abstract:
Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Stem cell banking offers faster transplantation, reduced waiting times, and cost-effective treatments for degenerative diseases. However, universal preservation methods remain challenging due to donor shortages. Cancer stem cells (CSC) differentiate into multiple normal cell lineages without reprogramming pluripotent factors and escape immune detection and destruction, offering a novel strategy for disease modeling, drug discovery, and economically viable cell therapy, potentially reducing immune rejection despite diversity among individuals human leukocyte antigen markers. The research was conducted in accordance with PRISMA guidelines. The literature, including terms such as cancer differentiation, stem cell banks, pluripotency, 3D cell culture, and plasticity, was searched through Google Scholar. The work cited in the selected articles was also searched for additional relevant literature. Several cancer types that responded to differentiation therapy were focused on during the research. Solid tumors, including melanoma, neuroblastoma, osteosarcoma, hepatocellular carcinoma, and breast cancer, were found to differentiate into normal cells, while other solid tumors, such as leukemia, glioma, skin cancer, ovarian cancer, and lung carcinoma, were found to differentiate into mature cells. Moreover, clinical studies show CSCs are non-tumorigenic after differentiation, making them a viable treatment option in regenerative medicine. And absolutely guarantee that, whether for an adult or newborn, it will amount to a viable treatment in the future that could one day prevent degenerative diseases.
Audience Take Away:
- The stem cell banking sector is rapidly growing, with public hospitals and private businesses exploring various types of stem cells because stem cell banking offers faster transplantation, reduced waiting times, and reduced costs, making allogeneic stem cells useful for treating various incurable degenerative diseases.
- The objective is to store cancer stem cells and use them in an emergency so that we can save time. Every time cells are needed, one sample from the stem cell bank is taken and a fresh dose is grown. Grand View Research predicts a global stem cell market of $31.6 billion by 2030, driven by increasing stem cell banks, therapeutic potential, and regenerative medicine research. CSCs can differentiate into normal cells of interest and will never be rejected by the host immune system upon allogeneic transplantation. Moreover, clinical studies show that CSCs, upon differentiation into normal cells, are not tumorigenic. The audience will learn a new strategy in stem cell therapy to treat many incurable degenerative diseases using cancer stem cell banks
