In the 1990s, tissue engineering promised to change healthcare forever. Images on the cover of journals showed humans with almost every organ regenerated using tissue engineering approaches. From bone to skin to the brain to the heart, tissue engineering was destined to change th [....] » Read More
After high-velocity trauma, de-vascularization leads to the death of vital structures including Bone, Tendons, Muscles and loose Skin flaps. Open fractures associated with prolonged exposure of the underlying tissue and the presence of infection are critical factors, leading to f [....] » Read More
Nanofat has been reported to enhance fat graft survival by promoting neovascularization. We previously introduced fat extract (FE), a cell-free component derived from nanofat, and demonstrated its proangiogenic potential. This study aimed to investigate the effect of FE and its c [....] » Read More
Macrophages dynamically polarise into specialised phenotypes to perform an array of functions as part of both the innate immune response and tissue homeostasis. The ability of macrophages to polarise stems from the sensitivity of these cells to the local tissue environment. The c [....] » Read More
The rapid development of 3D bioprinting technologies is important for tissue engineering, regenerative medicine and drug evaluation. Designed a Roll Porous Scaffold (RPS) technology describes the ways to overcome the main imperfection of extrusion-based bioprinting and 2D “ [....] » Read More
Chronic, non-healing diabetic wounds put a massive economic burden on health services causing patient incompliance and discomfort. Thorough interpreting of chronic wound pathophysiology led to the fabrication of targeted systems of drug delivery that can improve and accelerate th [....] » Read More
Polyhydroxyalkanoates (PHA) exhibit tremendous potential for bone tissue regeneration, owing to their biocompatibility and biodegradability. To address limitations in supporting bone growth, researchers have employed a strategic approach of reinforcing PHA with calcium phosphate [....] » Read More
The decellularized tissue is famous for grafts that can be a combined growth factor. One tissue graft is dermal matrix-derived animal skin, and the source of the cocktail growth factor is platelet-rich plasma. The study developed a dermal matrix from a goat that combined with het [....] » Read More
The goal of this research is to develop a bioprinted 3D tissue model system for disease modeling and treatment with a focus on the cardiovascular and cerebrovascular systems. Such studies have been typically limited to two-dimensional (2D) culture systems, which fail to capture t [....] » Read More
L1CAM (L1, CD171) is a cell surface immunoglobulin superfamily protein normally involved in axon guidance, differentiation, and cell migration during development. LI also is expressed abnormally in many types of cancers including breast, pancreatic, colon, melanoma and glio [....] » Read More
Melanoma metastases develop through genomic changes in the tumor cells and through microenvironmental factors that create an immunosuppressive tissue microenvironment. Historically the median life expectancy for patients with stage IV melanoma was less than one year. Modulation o [....] » Read More
Skeletal tissue injury is a major burden on the global healthcare system due to an aging population. In addition, metabolic disorders such as diabetes and osteoporosis further impede the healing process. Tissue engineering scaffolds for reconstructive strategies offer exciting op [....] » Read More
One of the ways to obtain tissue-specific scaffolds is decellularization. The tissue-specific extracellular matrix (ECM) proteins preserved during decellularization make it possible not only to optimize the conditions for prolonged vital activity of attached cells but also to sti [....] » Read More
Background: Osteoarthritis (OA) is a degenerative disease linked to metabolic syndrome and chronic inflammation. Studies show that metabolic management is important in regenerative medicine treatments for degenerative diseases, including OA. The connection between metabolic sy [....] » Read More
BACKGROUND: Patients with traumatic brain injury (TBI) frequently experience chronic motor deficits, for which no approved pharmacological or biological agents are available. OBJECTIVE: To determine whether the stereotactic intracranial implantation of allogeneic modified bone [....] » Read More
Malignant melanoma is the most malignant skin tumor, which is prone to distant transfer. At present, the research methods are limited, and there is an urgent need to find new treatment targets. The results showed that UT-B overexpression in B16 cells would inhibit the cytosocytic [....] » Read More
Aging leads to a progressive decline in homeostasis and regenerative function, including age-related degeneration of stem cell function. In order to investigate whether there were differences in the functions of spermatogonial stem cells(SSCs) at different periods, magnetic activ [....] » Read More
Ovarian cancer is one of the most common gynecological malignancies. Because the early typical symptoms are not obvious, the lack of effective screening means, its mortality is the highest in gynecological tumors. Therefore, the prevention and treatment of ovarian [....] » Read More
Ovarian cancer is one of the malignancies of the female reproductive system. Due to the lack of clinical symptoms in the early stage, it is very important to study the mechanism of the occurrence and development of ovarian cancer at the molecular level for early diagnosis and pro [....] » Read More
Full-thickness wounds are a growing problem due to high costs and complications. pH variations in the wound healing process are divided into four stages: homeostasis, inflammation, proliferation, and regeneration. The transition from the inflammatory phase to the proliferative ph [....] » Read More
Acute peritonitis is a relatively common intra-abdominal infection that a general surgeon will have to manage many times in his surgical carrier. Usually it is a secondary peritonitis caused either by direct peritoneal invasion from an inflamed infected viscera or by gastrointest [....] » Read More
The fabrication of human tissues and organs exhibiting structural, mechanical and biological function remains a major challenge due to their structural complexity, multicellular composition, spatial heterogeneity of the ECM and, in most cases, the presence of a vascular network. [....] » Read More
Advances in preclinical models have allowed the creation of animals with genetic alterations that tolerate xenogeneic transplants of human hepatocytes. Over time, the loss of native (murine) hepatocytes is replaced by human cells leading to a “humanization” [....] » Read More
An analysis of the morbidity and mortality of medical personnel in different countries revealed an interesting pattern: surgeons and nurses were most often ill and dying. At the same time, the most likely version is that medical personnel violated the anti-epidemic regime. [....] » Read More
Cholelithiasis presents in approximately 20% of the total population, ranging between 10% and 30 %. It presents one of the most common causes for non malignant surgical treatment. The cornerstone therapy is laparoscopic cholecystectomy, urgent of elective. Laparoscopic cholecyste [....] » Read More
In recent years, mesenchymal stem cell (MSC) therapy has been investigated in dogs, but inconsistent outcomes have been observed. Stromal Vascular Fractions (SVFs) present a heterogeneous cell population, including MSCs, progenitor cells, endothelial cells, pericytes, and immune [....] » Read More
Accumulated evidence has emerged on the role of stem cells in key cellular functions such as their implication in host immune response and tissue regeneration. Currently, Mesenchymal Stromal Cells (MSCs), which are multipotent stem cells, have been used in a great number of clini [....] » Read More
Nowadays, biomedical engineering makes great attempts to develop materials that could imitate living tissues (mechanical properties or biocompatibility). Among them is polyetheretherketone (PEEK) which despite owing very similar mechanical properties to human bones, does not indu [....] » Read More
Warm ischemia is widely used in the treatment of renal cell carcinoma for improvement of tumor visual assessment, minimizing blood loss and providing hemostasis during partial nephrectomy. However, the resulting process of acute hypoxia leads to critical consequences for the heal [....] » Read More
The damaged nervous system leads to the impairment of the motor, sensory and autonomic functions, since the central nervous system (CNS) regeneration is very limited. Failure of axon regeneration in the CNS is partly due to the inhibitory environment, and partly due to the intrin [....] » Read More
3D cell cultures are superior in resembling the natural physiological settings of tissues compared to 2D cell cultures that limit mass transport and cell-cell interactions to two directions. The number of cells encapsulated in droplets can be regulated by controlling the cell con [....] » Read More
Hepatic progenitor cells (HPCs) form ductular reactions and peritumoral ductules in the postnatal liver. HPCs are facultative progenitors mainly derived from normal cholangiocytes activated in response to injury. Ductular reactions are observed in several chronic liver diseases, [....] » Read More
A cell type is determined by the network function of its cell identity genes, including master transcription factors that govern the expression status of this network. Cell identity transition is fundamental in normal differentiation and development, whereas a cell that loses its [....] » Read More
Biomaterials are used in regenerative medicine as wound dressings, implantable materials, controlled-release carriers, or scaffolds for tissue engineering. Chronic, nonhealing wounds are a serious problem for people suffering from diabetes. Therefore, various scientific groups ha [....] » Read More
Placental-derived mesenchymal-like adherent stromal cells (MLASCs) are proprietary culture expanded, undifferentiated mesenchymal-like adherent stromal cells derived from full term placental tissue that have immuno-modulatory and anti-inflammatory properties. These cells are avai [....] » Read More
Introduction:The high prevalence of peri-implantitis reflects the lack of effectiveness of treatment methods, which makes the search for new therapeutic approaches relevant.The use of hyaluronic acid in the treatment of peri-implantitis is expedient, which determined the purpose [....] » Read More
Diabetic foot ulcers are prevalent and long-term complications of diabetes mellitus with significant health care influences and costs. These mentionable instances of chronic wounds can be accompanied by other severe complications, including limb amputation and gangrene, infection [....] » Read More
Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Stem cell banking offers faster transplantation, reduced waiting times, and cost-effective treatments for degenerative diseases. However, universal preserva [....] » Read More
Title : RNA activation in cancer and rare genetic diseases
Nagy Habib, Imperial College London, United Kingdom
Small activating RNAs (saRNA) are double stranded 21 nucleotide RNA that either target promoters or enhance genes leading to mRNA upregulation. saRNAs can be delivered with liposomes into the systemic circulation or subcutaneously by conjugation with aptamers or GalNAC. [....] » Read More
Title : Novel molecular mechanisms and therapeutic options for pulmonary hypertension
Yong Xiao Wang, Albany Medical College, United States
Pulmonary hypertension (PH) is a common and devastating lung disease. The current primary medications for this disease are to use non-specific vasodilators, but patients do not always respond well to non-specific vasodilators. Voltage-dependent potassium channels and store-operat [....] » Read More
Title : Characterization of Mesenchymal Stem Cells (MSCs) and their use in the treatment of COVID-19
Vasiliki E Kalodimou, Director Flow Cytometry-Research, Greece
Worldwide more than 49 million individuals have been infected with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the corona virus causing COVID-19. From the World Health Organization, as of November 6, 2020, a little over 1.2 million deaths have been reported glo [....] » Read More
Title : Biofabrication of functional human intestinal tissue with villi and crypts using high-resolution 3D printing technique
Lindy Jang, Lawrence Livermore National Laboratory, United States
The epithelium of the small intestine is composed of villi that protrude into the gut lumen like fingers and crypts that are epithelial invaginations. The architecture of villi and crypts is critical to maintain intestinal homeostasis and renewal. In recent years, researchers hav [....] » Read More
Title : IPSC-MSCs for cell and gene therapy in cartilage repair
Tong Ming Liu, Institute of Molecular and Cell Biology (IMCB), Singapore
Human mesenchymal stem cells (MSCs) represent the most used stem cells for clinical application, which have been used in over 1500 clinical trials to treat over 30 diseases due to multilineage differentiation potential, secretome and immunosuppression. The clinical application of [....] » Read More
Title : Laminin peptides attached to hydrogels may serve as flexible scaffolds for tissue repair
Georgios Koliakos, Biohellenika Biotechnology, Greece
Tissue engineering and regenerative medicine seek innovative solutions to promote effective tissue regeneration. Laminins, essential components of the extracellular matrix, possess unique cell-adhesive properties crucial for tissue development and repair. A series of laminin deri [....] » Read More
Title : Next generation 3D-bioprinting through superior software modelling
Jordan Copner, Copner Biotech Ltd, United Kingdom
The 3D-bioprinting industry has witnessed significant breakthroughs and advancements through the last 10 years, including but not limited to, novel methods of material deposition and highly tuneable bioinks for printing. Whilst the industry has enjoyed a clear advancement in hard [....] » Read More
Title : Ultra-high throughput multiphoton 3D bio-printer
Linas Jonusauskas, Vital3D Technologies, Lithuania
Fast development in the field of 3D bio-printing showed immense promise in the capability to produce fully functional organs for in vitro testing or even in vivo implantation. However, while there is an abundance of methodologies that can be employed in this role, the challenge o [....] » Read More
Title : Rat kidney decellularization in purpose of development of tissue engineering scaffold and recellularization with human mesenchymal stem cells derived from human umbilical cord
Charalampos Oikonomidis, Biomedical Research Foundation Academy of Athens, Greece
Chronic kidney disease is a prevalent global issue as the 18th leading cause of death worldwide. The escalating demand for kidney transplants has prompted the scientific community to explore alternative strategies. In such a way, one promising alternative strategy to address the [....] » Read More
Title : Biodegradable electrospun PCL/GEL nanofibers: Effect of tubular halloysite on physical and biological properties
Viera Khunova, Slovak University of Technology, Slovakia (Slovak Republic)
Tubular halloysite (HNT) is environmentally friendly, biocompatible, naturally occurring aluminosilicate clay with unique structure and properties. In this study the effect of HNT structure on properties of biocompatible electrospun nanofibers based on blend of hydrophobic, synth [....] » Read More
Title : Biodegradable ultrathin nanofibrous membranes for retinal tissue engineering
Hana Studenovska, Institute of Macromolecular Chemistry, CAS, Czech Republic
Degenerative retinal diseases such as age-related macular degeneration (AMD) impair the function of the retinal pigment epithelium (RPE), which results in failure of photoreceptors and loss of vision. Replacement of the RPE by a transplantation of retinal cells via nanofibrous me [....] » Read More
Title : In vitro and in vivo osteogenic potential of bioactive glass PVA hybrid scaffolds colonized by mesenquimal stem cells
Viviane Gomide Kawa, Pontifical Catholic University of Minas Gerais, Brazil
Bioactive glass/polymer composites are promising materials for bone tissue engineering. In this project has developed porous hybrid scaffolds comprised of 50% polyvinyl alcohol/50% bioactive glass with a 70%SiO2–30%CaO composition. Prior studies have also shown the adequate [....] » Read More
Title : Optimizing electrospun biodegradable small diameter vascular graft via 3D printing reinforcement achieved a long-term patency neotissue formation in a small animal model
Obiweluozor Francis Onyekachi, Chonnam University Hospital and Medical school, Korea, Republic of
Step-wise increase in cases of patients with cardiovascular disease globally has propelled scientist in this area to develop improved commercially available artificial blood vessel with large diameter for reducing adverse responds that drive acute thrombosis and the accompanying [....] » Read More
Title : A long-acting bioactive patch consisting of copolymers with inherent antimicrobial properties
Argyro Niti, Biohellenika Biotechnology, Greece
Statement of the Problem: Wound healing takes place in successive but overlapping stages involving cells, bioactive agents and the extracellular matrix. The last decades, a number of "bioactive" patches have been developed inspired by the normal mechanisms of healing, i [....] » Read More
Title : Bioengineering of identifying transcriptional elements driving MMP13 gene in skeletal development
Sara Ibrahim AlSalhi, University of Liverpool, United Kingdom
MMP13 is a primary catabolic factor involved in cartilage degradation through its ability to cleave type II collagen. Transcriptionally, MMP13 is regulated by 2 main elements: proximal prompter and distal enhancers by both molecular and epigenetic factors. The&nbs [....] » Read More
Title : Strategy to promote neovascularization and fibrinolysis in vascular disease
Darwin Eton, Vasogenesis Inc, United States
Neovascularization (NV) via growth of collateral arteries (arteriogenesis) and capillaries, arterioles, and venules (angiogenesis) becomes impaired as ischemia from vascular disease progresses. Our premise is that overcoming hemodynamic and cellular obstacles to NV should yield a [....] » Read More
Title : Influence of exposure to pesticides on telomere length and pregnancy outcome: Diethyl phosphates but not dimethyl phosphates are associated with accelerated telomere attrition in a palestinian cohort
Jaber Jamil Haj Ali, Consulting Medical Lab, State of Palestine
Exposure to environmental pesticides during pregnancy is associated with adverse health outcomes such as low birth weight and impaired neuro-development. In this study, we assessed maternal leukocyte telomere lengths (TL) in Palestinian pregnant women and compared the data with u [....] » Read More
Title : Cellular conflict, degenerative disease onset, and nutritional demands: A novel insight into the role of single-cell nutrients as an adjuvant to cell therapy
Samar Hassab Allah Kassem Mohamed, October 6 University, Egypt
As the incidence of degenerative disease increases with age, we argue that conditions are related to nutritional defects in a particular organ. As not all genetic risk factors trigger diseases in old age, other factors likely intervene. Many recent studies have revealed nutrition [....] » Read More
Title : The role of efferocytosis in stem cell-based tissue engineering
Seyed Mohammad Gheibihayat, Shahid Sadoughi University of Medical Sciences, Iran (Islamic Republic of)
Tissue engineering is a rapidly evolving field that aims to develop new approaches for tissue regeneration using a combination of cells, growth factors, and biomaterials. Stem cells, in particular, hold great promise for tissue engineering due to their ability to differentiate in [....] » Read More
Title : Exploration of the cGMP-PKG-dependent transcriptome in photoreceptors via spatial capture technology
Jiaming Zhou, The Technology Innovation Institute (TII), United Arab Emirates
Retinitis pigmentosa (RP) refers to a group of inherited disorders that lead to the dysfunction and death of photoreceptors, which causes progressive vision loss, and there is in principle no treatment available. The cGMP-PKG system has been suggested as a disease driver in sever [....] » Read More
Title : NIR-degradable and biocompatible hydrogels derived from hyaluronic acid and coumarin for drug delivery and bio-imaging
Kwon Taek Lim, Pukyong National University, Korea, Republic of
In this work, bioorthogonal and photodegradable hydrogels derived from norbornene (Nb) functionalized hyaluronic acid and a water soluble coumarin-based cross-linker possessing terminal tetrazine (Tz) groups, were developed for NIR-responsive release of doxorubicin (DOX). The inv [....] » Read More
Title : Corneal tissue engineering at a glance
Raihaan Biju, Imperial College London, United Kingdom
Tissue engineering and regenerative medicine (TERM) has been growing rapidly and is a promising approach to address the limitations of traditional corneal transplantation and revolutionise corneal therapy. This poster provides an overview of what corneal tissue comprises of and w [....] » Read More
Title : Preliminary data of adipose stem cells and stem cells markers by flow cytometry and their use in regenerative medicine-plastic surgery
Maria Toumazou, EUC School of Medicine, Germany
In the field of regenerative medicine, basic research and preclinical studies have been conducted to overcome clinical shortcomings with the use of mesenchymal stem cells. They are present in adult tissues, including bone marrow and adipose tissue. For many years, bone marrow-der [....] » Read More
Title : MicroRNA-155 in mononuclears as a predictor of acute kidney injury in patients with ST-elevation myocardial infarction
Oleksandr Sopko, ACVC Regular Member, Ukraine
Acute kidney injury (AKI) in patients with ST-elevation myocardial infarction (STEMI) is a substantial problem, particularly, its prediction and therapy approaches. Earlier we analyzed the change of microRNAs subset in different blood fractions (plasma, platelets, mononuclears), [....] » Read More