The fabrication of human tissues and organs exhibiting structural, mechanical and biological function remains a major challenge due to their structural complexity, multicellular composition, spatial heterogeneity of the ECM and, in most cases, the presence of a vascular network. [....] » Read More
Chronic, non-healing diabetic wounds put a massive economic burden on health services causing patient incompliance and discomfort. Thorough interpreting of chronic wound pathophysiology led to the fabrication of targeted systems of drug delivery that can improve and accelerate th [....] » Read More
Abstract Osteoarthritis (OA) is the most common form of arthritis which is a degenerative joint disease causing joints to begin to break down and underlying bones to change. This “wear and tear” most frequently affects hands, hips and knees. This is important because [....] » Read More
Musculoskeletal system is an integral part of the human body which plays a crucial role to give its form and structure. Bone loss in any way is detrimental for human existence and a perfect bone substitute that can heal, reform and regenerate the lost tissues is unavailable at pr [....] » Read More
Accumulated evidence has emerged on the role of stem cells in key cellular functions such as their implication in host immune response and tissue regeneration. Currently, Mesenchymal Stromal Cells (MSCs), which are multipotent stem cells, have been used in a great number of clini [....] » Read More
The rapid development of 3D bioprinting technologies is important for tissue engineering, regenerative medicine and drug evaluation. Designed a Roll Porous Scaffold (RPS) technology describes the ways to overcome the main imperfection of extrusion-based bioprinting and 2D “ [....] » Read More
Currently, the use of mesenchymal stem cells (MSCs) has emerged as an effective alternative in regenerative medicine. It is believed that the success of therapy for regeneration, mainly cutaneous, is due to the reduction of inflammation, increased cell viability and differentiati [....] » Read More
In order to study the rehabilitation progress of a patient undergoing anterior cruciate ligament (ACL) reconstruction surgery on the right leg. This subject was compared with a healthy patient who performs physical activity with regularity. They carried out similar physical activ [....] » Read More
Hydrogels and their medical applications in tissue engineering have been widely studied due to their three-dimensional network structure, biocompatibility, and cell adhesion. However, the development of an artificial bile duct to replace the recipient’s tissue is still desi [....] » Read More
Ovarian cancer is one of the most common gynecological malignancies. Because the early typical symptoms are not obvious, the lack of effective screening means, its mortality is the highest in gynecological tumors. Therefore, the prevention and treatment of ovarian [....] » Read More
Malignant melanoma is the most malignant skin tumor, which is prone to distant transfer. At present, the research methods are limited, and there is an urgent need to find new treatment targets. The results showed that UT-B overexpression in B16 cells would inhibit the cytosocytic [....] » Read More
Ovarian cancer is one of the malignancies of the female reproductive system. Due to the lack of clinical symptoms in the early stage, it is very important to study the mechanism of the occurrence and development of ovarian cancer at the molecular level for early diagnosis and pro [....] » Read More
Aging leads to a progressive decline in homeostasis and regenerative function, including age-related degeneration of stem cell function. In order to investigate whether there were differences in the functions of spermatogonial stem cells(SSCs) at different periods, magnetic activ [....] » Read More
Title : A revolution or surrender: The success and failures of tissue engineering and regenerative medicine
Thomas J Webster, Hebei University of Technology, United States
In the 1990s, tissue engineering promised to change healthcare forever. Images on the cover of journals showed humans with almost every organ regenerated using tissue engineering approaches. From bone to skin to the brain to the heart, tissue engineering was destined to change th [....] » Read More
Title : Efficacy and safety outcomes in patients with chronic traumatic brain injury: Final analysis of the randomized, double-blind, surgical sham-controlled phase 2 STEMTRA trial
Bijan Nejadnik, SanBio, Inc, United States
BACKGROUND: Patients with traumatic brain injury (TBI) frequently experience chronic motor deficits, for which no approved pharmacological or biological agents are available. OBJECTIVE: To determine whether the stereotactic intracranial implantation of allogeneic modified bone [....] » Read More
Title : Biofabrication of functional human intestinal tissue with villi and crypts using high-resolution 3D printing technique
Lindy Jang, Lawrence Livermore National Laboratory, United States
The epithelium of the small intestine is composed of villi that protrude into the gut lumen like fingers and crypts that are epithelial invaginations. The architecture of villi and crypts is critical to maintain intestinal homeostasis and renewal. In recent years, researchers hav [....] » Read More
Title : A 3D -bioprinted in vitro adipose tissue model for the study of macrophage polarisation and function within metabolic disease.
Tiah Oates, University of Bristol, United Kingdom
Macrophages dynamically polarise into specialised phenotypes to perform an array of functions as part of both the innate immune response and tissue homeostasis. The ability of macrophages to polarise stems from the sensitivity of these cells to the local tissue environment. The c [....] » Read More
Title : Comparison of different nanofiber scaffolds effects on bone regeneration of calvaria defect in a wistar rat model _importance of porosity
Fanny Gimie, Gip Cyrio, France
Abstract Skeletal tissue injury is a major burden on the global healthcare system due to an aging population. In addition, metabolic disorders such as diabetes and osteoporosis further impede the healing process. Tissue engineering scaffold for reconstructive strategies offer exc [....] » Read More
Title : Influence of exposure to pesticides on telomere length and pregnancy outcome: Diethylphosphates but not dimethylphosphates are associated with accelerated telomere attrition in a Palestinian cohort
Jaber Jamil Haj Ali, University Medical Center, Germany
Exposure to environmental pesticides during pregnancy is associated with adverse health outcomes such as low birth weight and impaired neuro-development. In this study, we assessed maternal leukocyte telomere lengths (TL) in Palestinian pregnant women and compared the data with u [....] » Read More
Title : The development of an open-source low-cost 3d “micro”-bioprinter
Lauren R Harrison, McGill University, Canada
The impact of three dimensional (3D) bioprinting within the tissue engineering field has grown significantly in recent decades. 3D bioprinting allows for automated and accurate high- throughput fabrication of functional tissues and organs using a layer-by-layer bottom-up printing [....] » Read More
Title : Biodegradable ultrathin nanofibrous membranes for retinal tissue engineering
Hana Studenovska, Institute of Macromolecular Chemistry, Czech Republic
Degenerative retinal diseases such as age-related macular degeneration (AMD) impair the function of the retinal pigment epithelium (RPE), which results in failure of photoreceptors and loss of vision. Replacement of the RPE by a transplantation of retinal cells via nanofibrous me [....] » Read More
Title : Optimizing electrospun biodegradable small diameter vascular graft via 3D printing reinforcement achieved a long-term patency neotissue formation in a small animal model
Obiweluozor Francis Onyekachi, Chonnam University Hospital and Medical school, Korea, Republic of
Step-wise increase in cases of patients with cardiovascular disease globally has propelled scientist in this area to develop improved commercially available artificial blood vessel with large diameter for reducing adverse responds that drive acute thrombosis and the accompanying [....] » Read More
Title : Investigation of trace elements in Nigerian women with breast cancer using particle-induced xray emission (PIXE) analysis
Olaiya David Olubunmi, Obafemi Awolowo University, Nigeria
This study determined the variations in trace elements level in cancer patients, non-cancer patients and compared concentrations of trace elements in cancerous and non-cancerous breast tissues. This was with a few to understanding the effects of trace elements in the etiology of [....] » Read More
Title : Early and automatic breast cancer detection and screening using thermal imaging
Alamirew Kefale, University of Gondar, Ethiopia
Breast cancer is one of the deadliest forms of cancer in women but the disease has a good prognosis when diagnosed early. Existing breast cancer diagnosis devices are mammography, breast ultrasound, breast MRI scan and breast biopsy. But the gold standard for the diagnosis of bre [....] » Read More
Title : MicroRNAs in the composition of platelet- Rich fibrin
Indre Jasineviciute, Lithuanian University of Health Sciences, Lithuania
Regenerative effectiveness of platelet-rich fibrin has been discussed in previous clinical research, but information about its composition related to cellular and genetic composition is lacking. A three-dimensional fibrin matrix in platelet-rich fibrin attracts and traps signific [....] » Read More
Title : Ultra-high throughput multiphoton 3D bio-printer
Linas Jonusauskas, Vital3D Technologies, Lithuania
Fast development in the field of 3D bio-printing showed immense promise in the capability to produce fully functional organs for in vitro testing or even in vivo implantation. However, while there is an abundance of methodologies that can be employed in this role, the challenge o [....] » Read More
Title : Ocular surface regeneration; current strategies and the considerable candidates.
Sara Aghazadeh, Aalborg University, Denmark
The ocular surface comprises the cornea, the outermost layer of the eye. As it is exposed, genetic and environmental factors can affect it and cause permanent deficiencies. Limbal stem cells (LSCs), reside in the basal layer of the epithelium and regenerate the ocular surface. An [....] » Read More
Title : Control release of dexamethasone from 3D printed scaffolds promotes M2 like Macrophage and enhanced Osteogenic Differentiation of MSCs
Majed Majrashi, University of Nottingham, United Kingdom
The immune system plays a vital role in inducing inflammation, tissue repairing and regeneration. Currently, there is an endeavour to investigate the role of macrophages in bone tissue regeneration. It has been elucidated that macrophages can polarise to proinflammatory M1 and an [....] » Read More