Title : SIRT1 inhibits metastasis of ovarian cancer cells through ERß-mediated autophagy
Abstract:
Ovarian cancer is one of the most common gynecological malignancies. Because the early typical symptoms are not obvious, the lack of effective screening means, its mortality is the highest in gynecological tumors. Therefore, the prevention and treatment of ovarian cancer remains a huge challenge. It was found that the silent information regulator 1 (SIRT1) was low expressed in ovarian cancer tissues, and the increased expression of SIRT1 inhibited the metastasis of ovarian cancer cells, but the molecular mechanism was not clear. As a histone deacetylase, SIRT1 is involved in the regulation of autophagy, energy metabolism, cancer and other physiological and pathological processes. SIRT1-induced autophagy can delay the formation of atherosclerosis and the progression of neurodegenerative diseases. However, there are few studies on the role of SIRT1-induced autophagy in the process of tumor metastasis in ovarian cancer. Our previous work found that estrogen receptor beta (ERβ) could induce autophagy to inhibit metastasis of breast cancer cells through the claudin6/beclin1 axis. The expression of ERβ was low in ovarian cancer tissues and correlated with the expression of SIRT1.Therefore, we speculated that ERβ might be the target gene of SIRT1, and SIRT1 could induce autophagy and inhibit the
metastasis of ovarian cancer cells through ERβ.The study provides a theoretical basis for the search of molecular markers and targeted therapy for early metastasis of ovarian cancer.
Audience Take Away:
- You can study the role of SIRT1 in inducing autophagy in ovarian cancer cells.
- You can learn the relationship between SIRT1-mediated autophagy and ovarian cancer metastasis.
- You can study the regulatory relationship between SIRT1 and ERβ in ovarian cancer cells.
- This study elucidates the mechanism of SIRT1/ERβ in ovarian cancer metastasis, and provides valuable theoretical and experimental basis for the early diagnosis and drug development of ovarian cancer.
