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5th Edition of International Conference on Tissue Engineering and Regenerative Medicine

September 18-20 | London, UK

September 18 -20, 2025 | London, UK
TERMC 2024

Modifications of chitin-glucan complex in ionic liquids: A tool to generate nanostructured materials for tissue engineering

Ivan Kelnar, Speaker at Tissue Engineering Conferences
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Czech Republic
Title : Modifications of chitin-glucan complex in ionic liquids: A tool to generate nanostructured materials for tissue engineering

Abstract:

Chitin and related chitosan are important biopolymers with antibacterial activity, even more medically relevant effects possess various types of water soluble glucans. Both polysaccharides are present mainly in various fungi like Aspergillus niger, which also contain important or even dominant fraction of chitin-glucan complex (CGC). In spite of its high suitability for different medicinal applications, the potential of CGC is not fully exploited due to insolubility in most of traditional solvents. In this area is most effective way application of various ionic liquids (IL), which allow or even support many chemical modifications. In this work we focused on parallel modifications of both constituents of CGC, including grafting of polymer chains. Presented are effects of modification on solubility in IL and other solvents including formation of self-assembled structures. In the case of polycaprolactone and polylactide chains grafting, effects of such modifications on ordering in IL is highlighted. This work was supported by Ministry of Education Youth and Sports  of the Czech Republic (Grant LUAUS 23004)

Audience take away Notes:

  • Highlighting of chemical modifications of CGC
  • Effect of chemical modifications of CGC on ordering in IL
  • Introduction of a new tool to prepare CGC-based nanostructures

Biography:

Ivan Kelnar is head of the Department of nanostructured polymers and composites at the Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic.  His research is mainly focused on structure-properties relationships in polymer systems with complex structures, especially rigid/soft self-assembled nanostructures and interfaces also based on modified polysaccharides. Most of the research is done within national and international projects, published in more than 100  research articles.

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