Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
The field of tissue engineering combines the use of cells, biologically active molecules, and biomaterials to create functional tissues. Hydrogels, which are 3D networks of polymeric materials (both natural and synthetic), can absorb substantial amounts of water and swell in aque [....] » Read More
Bioprinting has emerged as an attractive technology to treat tissue injuries. The most common approach in 3D printing is performed based on plane layering. When the bioprinted implant slides over other tissue (e.g. when the injury is in a joint), the stair-step effect of a typica [....] » Read More
The erythrocytes in flow are continually changing their shape in a synchronized erratic fashion. Then, there is a natural crossover between the mathematical field of Brownian motion and medicine. Eugene Wigner, one of the important physicists of the twenty's century claimed: [....] » Read More
For many years nitric oxide NO, hydrogen sulfide H2S and carbon monoxide CO have been considered toxic gases which at low concentrations present in the atmosphere. Then all these gases have been discovered to be produced endogenously to regulate numerous key physiological functio [....] » Read More
Eye related diseases can cover diseases of the front segment of the eye as e.g. limbal stem cell deficiency (LSCD) but also diseases related to the back segment, the retina, as e.g age-related macular degeneration (AMD). In both cases one of the ways to treat the impaired part of [....] » Read More
Defects in vascular cells can contribute to peripheral vascular disease, stroke, atherosclerosis/thrombosis, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, dementia, and some severe viral infectious diseases. However, the recognition of ECs as dis [....] » Read More
To investigate if SCT cells are able to migrate and contribute to cartilage in CSD, we transplanted tissues with fluorescently labelled CT cells to the wildtype host prior to fracture surgery. The labelled CT cells are migrating to the CSD gap, and some are expressing cartilage p [....] » Read More
Adipose stem cell therapy, also known as adipose-derived stem cell therapy, is a promising approach in the treatment of various conditions, including ischemia. Ischemia refers to a condition where there's an inadequate blood supply to tissues, often resulting in tissue damage [....] » Read More
In this study, we found that the phospholipase C delta1 (PLCD1) protein expression is reduced in colorectal tumor tissues compared with paired surgical margin tissues. PLCD1-promoted CpG methylation was detected in 29/64 (45%) primary colorectal tumors, but not in nontumor tissue [....] » Read More
Multiple sclerosis (MS) is a serious neurological problem because of its high prevalence, chronic course, frequent disability, and propensity to affect young people. The immunopathogenesis hypothesis underlies the origin of MS. Selective sorption activity of biocompatible magneti [....] » Read More
INTRODUCTION : Application of Regenerative medicine in Orthopaedics includes use of modalities specifically aimed at replacing and / or repairing damages cells, tissues in cartilage, bones and joints in order to restore or improve their function. OBJECTIVES : Highlighting the [....] » Read More
Improvements in the Roll Porous Scaffold 3D bioproduction technology will increase print density of 10−15 µm cells by ~20% up to ~1.5×10^8 cells/mL and clarity by >10%. The analogues of the proposed solution are only indirect, much more expensive and less tec [....] » Read More
INTRODUCTION The exposed wound of bone and tendon caused by trauma has always been the focus and difficulty in clinical work. The traditional treatment scheme is skin flap transplantation to repair the wound after debridement. However, this kind of technique not only solves the p [....] » Read More
Bypass surgery, using the autologous vein has been one of the most effective treatments for cardiovascular diseases. More recently tissue engineering including engineered vascular grafts to synthesize blood vessels is gaining usage. Dacron and ePTFE has been employed for vascular [....] » Read More
Cell and gene therapies hold promise for brain repair in disorders of the central nervous system. Here, I will focus on stroke and brain disorders associated with vascular dysfunction, particularly blood-brain barrier (BBB) breakdown. I will review the basic pathophysiology of [....] » Read More
Microgravity is one of the most significant stress factors experienced by living organisms during spaceflight. Controlled in vitro studies of cells and tissues under the conditions of microgravity can improve our understanding of gravity sensing, transduction and responses in liv [....] » Read More
Skeletal tissues, bone and cartilage, do not regenerate in humans. While bone fractures can repair themselves, critical size bone defects do not, nor does the avascular cartilage. Hence, repair of these tissues is often achieved using autologous grafts. This, however, can result [....] » Read More
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This study included a total of 30 patients with finger tip defects in the Department of Bone and Soft Tissue Repair and Reconstructive Surgery of the Second Affiliated Hospital of Dalian Medical University from January 2020 to January 2023. The causes of patient injuries include: [....] » Read More
Our research goal is to characterize cartilage-derived progenitors, isolate a purer population of cells with enhanced chondrogenic potential, and apply this knowledge towards the evolution of improved therapeutics for the regeneration of genuine hyaline-like cartilage. In the fie [....] » Read More
The clinical treatment for esophageal defects is a huge challenge as it leads to poor quality of patient life, where the conduit tissue taken from the patients’ stomach, jejunum or colon is implanted in the damaged region. The treatment comes along with many post operative [....] » Read More
Tissue engineering is the latest technology in creating artificial tissues ex vivo (outside the body). One of the materials for tissue engineering is scaffolds derived from the decellularization of xenograft tissues from animals, such as chicken tissues. One of the artificial tis [....] » Read More
Leukemia, a type of cancer that affects the blood and bone marrow, is a complex and devastating disease with limited treatment options. Over the years, researchers have been exploring novel therapeutic approaches to improve patient outcomes. One emerging area of interest is the r [....] » Read More
Background: In addition to conventional commercial scaffolds in tissue engineering and regenerative medicine, currently, three-dimensional scaffolds with high biological activities have been able to open new perspectives for the repair of skin lesions, especially in patients with [....] » Read More
Withania somnifera (WS), a significant medicinal plant utilized in the Ayurvedic system, is a rich source of withanolides, which are pharmacologically active secondary metabolites. Withanolides, withaferin-A, withanolide-A, withanoside-IV, and certain sitoindosides are the primar [....] » Read More
The goal of tissue engineering is to create artificial living structures with structural organization and function that resemble native tissue. The deep zone of articular cartilage has a distinct anisotropic architecture with organized chondrocytes. In this area, aligned and para [....] » Read More
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Title : Artificial Intelligence (AI) in biomedical engineering
Hossein Hosseinkhani, Innovation Center for Advanced Technology, Matrix HT, United States
Application of Artificial intelligence (AI) in biomedical engineering technology is rapidly under development. The way AI applies in biomedical science is as the same as natural living cells consider playing the critical rules in their extracellular matrix environment. The presen [....] » Read More
Title : Connections between modern physics and practice regenerative medicine
Marco Polettini, DVM, Italy
A new autologous regenerative therapy, consistent with the laws of modern physics, is effective for anti-aging and for some diseases difficult to treat in veterinary medicine. This presentation briefly explains a very complex theory that is realized in a simple application techni [....] » Read More
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model to secure the human healthcare, wellness and biosafety: Through the view of cell-based therapy and rehabilitation
Sergey Suchkov, The Russian University of Medicine and The Russian Academy of Natural Sciences, Russian Federation
A principally new and upgraded systems approach to subclinical and/or diseased states and wellness resulted in a new trend in the healthcare services, is called as Personalized and Precision Medicine (PPM). But despite breakthroughs in translational research that have led to an i [....] » Read More
Title : Modifications of chitin-glucan complex in ionic liquids: A tool to generate nanostructured materials for tissue engineering
Ivan Kelnar, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Czech Republic
Chitin and related chitosan are important biopolymers with antibacterial activity, even more medically relevant effects possess various types of water soluble glucans. Both polysaccharides are present mainly in various fungi like Aspergillus niger, which also contain important or [....] » Read More
Title : Remote activation of mechanotransduction via integrin alpha-5 by aptamer conjugated magnetic nanoparticles promotes osteogenesis
Hadi Hajiali, University of Birmingham, United Kingdom
Introduction Magnetic particle (MNP) based technology platforms use superparamagnetic nanoparticles conjugated with targeting biomolecules to apply mechanical force directly to mechano-receptors on the cell surface, stimulating mechanotransduction and downstream signalling [1] [....] » Read More
Title : Bioprinted cell gradients to analyze nanoparticle uptake variability
Luigi Di Stolfo, University of Fribourg, Switzerland
Physical and chemical gradients in the human body are crucial for tissue development, function, and pathology. Replicating these gradients in in-vitro designs is essential to tissue engineering and disease research. The aim of this study is to design cell gradients using a bio [....] » Read More
Title : Tumor cell microspheroids induced by non-contact mechanical forces
Itziar Gonzalez, The Spanish National Research Council, Spain
We present a novel device actuated by ultrasound to induce rapid formation of cellular spheroids in very short times of less than 5 minutes, an order of magnitude less than those of conventional systems, which usually require more than 24h. It consists of a 2D polymeric array wit [....] » Read More
Title : Optimizing the regenerative effects on equine tendons and ligaments using a multi-frequency laser device as a standalone therapy: A methodological approach
Antonio Luciani, Luciani Equine Veterinary Consulting, Italy
In recent decades, extensive research has explored the effects of laser light on cells, resulting in well-documented photo-bio-modulation. The significant potential of laser light for tissue regeneration has been effectively applied to treat soft tissue injuries. Our developed me [....] » Read More
Title : The promising future of the unique translational tool to manage cardiac self-renewal and regeneration to secure the post-infarction period
Sergey Suchkov, The Russian University of Medicine and The Russian Academy of Natural Sciences, Russian Federation
The approaches securing cardiac regeneration in post-infarction period are not available to be practiced. The key problem is the identity of cells be born to generate functionally active cardiac myocytes replenishing those being lost during ischemia. With identification of reside [....] » Read More
Title : Durable immunomodulatory hierarchical patch for rotator cuff repairing
Liren Wang, Shanghai Jiaotong University, China
High re-tear rates exceeding 50% in degradable shoulder cuff patches, observed over a five-year follow-up, are attributed to the failure of degradable polymers alone to restore the inflammatory niche post-rotator cuff injury, hindering tendon-bone interface healing. Theoretically [....] » Read More
Title : Macrofluidic single use bioreactors
Gilad Gome, Hebrew University Faculty of Agriculture, Israel
One of the main challenges of cultured meat is reducing costs of production, often described as scaling. The main components of the operation are cells, media, scaffolds and bioreactors. This work presents an alternative to current stainless steel or glass bioreactors and uses pl [....] » Read More
Title : 4D printing of shape-memory polymer using a thermal stimulus for biomedical applications
Shubham Shankar Mohol, Indian Institute of Technology Delhi, India
Shape memory polymers (SMPs), as a class of smart materials, have demonstrated significant potential in the tissue engineering and soft robotics disciplines. The ability of MSMPs to store two shapes extends their applications in several fields. Additionally, 4D printing allows ad [....] » Read More
Title : Inflammation and the osteogenesis ability of mesenchymal stem cells the effect of natural compounds
Adel Mohammadalipour, Isfahan University of Medical Sciences, Iran (Islamic Republic of)
Inflammation has a significant impact on the osteogenic differentiation and function of mesenchymal stem cells (MSCs). Proinflammatory cytokines like TNF-α, IL-1β, and IL-6 have been shown to inhibit osteoblast differentiation, induce apoptosis in osteoblasts, and impa [....] » Read More
Title : Effect of human umbilical cord matrix stem cell conditioned media in cuprizone mice model of multiple sclerosis
Mohsen Marzban, Iranshahr University of Medical Sciences, Iran (Islamic Republic of)
Introduction: Human Umbilical Cord Matrix Stem Cells (h-UCMSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of h-UCMSCs supernatant or conditioned media in the cuprizone mice m [....] » Read More
Title : Histological evaluation of subcutaneous tissue reactions to a novel bilayer polycaprolactone/silk fibroin/strontium carbonate nanofibrous membrane for guided bone regeneration: A study in rabbits
Lida Kheiri, Shahid Beheshti University of Medical Sciences, Iran (Islamic Republic of)
The selection of appropriate biomaterial for guided bone regeneration is challenging. The blending of polymers is a simple method to retain their characteristics and to compensate for the drawbacks of each component. The release of Sr+2 (Strontium) ions from the Polycaprolactone/ [....] » Read More
Title : The emerging role of induced pluripotent stem cells and its derivatives in periodontal regeneration: A scoping review of preclinical studies
Lida Kheiri, Shahid Beheshti University of Medical Sciences, Iran (Islamic Republic of)
The main goal of periodontal regenerative therapy is to regenerate fully functional tissues that can replace the deteriorated ones resulted from periodontitis and injuries. Tissue engineering methods provide promising results in periodontium reconstruction and within its developm [....] » Read More
Title : In vitro model of endochondral ossification based on collagen-hyaluronic acid hydrogel with embedded chondrocytes
Marina Malic, Charles University, Czech Republic
Hydrogels are widely investigated biomaterials due to their potential to mimic the structure and function of the native extracellular matrix. We wanted to prepare a 3D in vitro model of endochondral ossification with focus on the cellular and material composition. To mimic the na [....] » Read More
Title : Pre-vascularized skin model in vitro
Yu Chieh Wu, Institute of Physiology, CAS, Czech Republic
Animal models have been used for decades in various physiological, pathophysiological, pharmaceutical, toxicological and other biomedical studies. However, significant obstacles of these models are ethical issues, considerable costs, and limited translatability of study outcomes [....] » Read More