Title : Selective MRI contrast with magnetite nanoparticles in malignant tumors: Hopes and challenges
Abstract:
In an experiment on rats, it was demonstrated that biocompatible standardized magnetite nanoparticles (ICNB) can be effectively used in MRI. It was proven that ICNB nanoparticles significantly enhance MRI imaging. The methodology for the safe intravenous administration of ICNB excludes the use of magnetite nanoparticles as an independent contrast agent for MRI. It was established that 24 hours after intravenous administration of ICNB, magnetite nanoparticles selectively accumulate in malignant tumor tissues with statistical significance, thereby increasing the brightness of the image. By the 4th day of the study, a statistically significant reduction in the brightness of the tumor and muscle images was observed, which was caused by the excretion of magnetite nanoparticles from the rat's body. The mechanism of action of ICNB nanoparticles induces reversible changes associated with a temporary increase in hydrogen proton mobility in the extracellular fluid. This inevitably modifies the metabolism of malignant cells, offering hope for the discovery of new approaches to targeted therapy for malignant tumors.
Keywords: Nanoparticles; ICNB; MRI; Malignant tumor; Contrast.
