Congenital diseases often present defects in multiple tissue and organs and require complex clinical care and in some cases surgical intervention. The use of autologous mesenchymal stem cells and patient derived cells from Induced Pluripotent Stem Cells (iPSCs) can allow one to s [....] » Read More
Background: Type 1 diabetes mellitus (T1D) is a chronic autoimmune disorder marked by the destruction of pancreatic β-cells, resulting in lifelong insulin dependency and associated complications. Traditional treatments, including insulin therapy, pancreas, and islet tra [....] » Read More
Tissue Engineering and Regenerative Medicine in the AI Era represents a transformative convergence of biology, materials science, and digital intelligence. Artificial Intelligence (AI) is reshaping how we design, fabricate, and apply regenerative therapies, accelerating the path [....] » Read More
Cognitive health is associated with the maintenance of a well-functioning cerebrovascular system throughout life. Because the aging population continues to grow worldwide, the risk and impact of age-related diseases is increasing. Over decades of aging research, several key biolo [....] » Read More
Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundr [....] » Read More
Blood vessels exhibit a range of structural and functional differences, contain a range of matrices and even specialized accessory cells that align with the specific needs of the tissue in which they reside. To study and recapitulate the highly complex behavior of blood vessels, [....] » Read More
This study investigated the in vivo immunomodulatory properties of canine Adipose tissue-Derived Stromal Vascular Fraction (AD-SVF) and xanthosine. AD-SVF, rich in mesenchymal stem cells, possesses inherent regenerative and anti-inflammatory capabilities. Xanthosine, a naturally [....] » Read More
The placenta is a non-controversial and readily available source of cells for regenerative medicine. The epithelial cells isolated from full-term amnion membrane contain several properties qualifying such cells as multipotent stem cells, with pluripotent characteristics and immun [....] » Read More
Problem Statement: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage breakdown and chronic inflammation. Interleukin-1 beta (IL-1β), a key pro-inflammatory cytokine in OA, disrupts iron metabolism, leading to excess intracellular iron and reactiv [....] » Read More
Polysaccharides elicit enormous and promising applications due to their extensive obtainability, innocuousness, and biodegradability. Various outstanding features of polysaccharides can be employed to fabricate biomimetic and multifunctional hydrogels as efficient wound dressings [....] » Read More
Introduction: Among the other tissue-resident adult stem cells, Mesenchymal stem cells (MSCs) are well characterized by their immune-modulatory and regenerative functionality (1). Impairment of tissue regeneration leads to fibrosis/ scar formation (2). To understand the mechanism [....] » Read More
The development of intelligent wound dressings has significantly advanced the field of wound care by offering both therapeutic benefits and diagnostic insights. This study focuses on a smart hydrogel bandage designed to provide real-time visual monitoring of wound healing progres [....] » Read More
The current global landscape highlights an escalating environmental crisis driven by pollution and climate change. Among the primary contributors, carbon dioxide (CO2) stands out as the most significant greenhouse gas, with atmospheric concentrations reaching unprecedented levels [....] » Read More
Background: In tissue engineering, hydrogels made from decellularized extracellular matrix (dECM) are gaining prominence because of their inherent biochemical composition and biocompatibility. They provide a platform for 3D bioprinting structures tailored to a given tissue. Hydro [....] » Read More
Background and Aim: Postburn permanent depigmentation, which occasionally results from deep partial-thickness and full-thickness burn injuries, remains a serious psychological problem for the affected people. To date, there has not been an available standard treatment for the pos [....] » Read More
Background: MSCs represent a heterogenous population of cells, which can be derived either from fetal (e.g. Wharton’s Jelly from umbilical cord, placenta, etc.) or adult human sources (e.g. Bone Marrow, Adipose Tissue, etc.). Recentrly, in our laboratory were able to i [....] » Read More
In an experiment on rats, it was demonstrated that biocompatible standardized magnetite nanoparticles (ICNB) can be effectively used in MRI. It was proven that ICNB nanoparticles significantly enhance MRI imaging. The methodology for the safe intravenous administration of ICNB ex [....] » Read More
In regenerative medicine, the selection of the optimal stem cell type is pivotal due to their diverse differentiation potentials and interactions with the extracellular matrix (ECM). Although Gellan Gum-based hydrogels have been extensively studied with various cell types, their [....] » Read More
Introduction: Interleukin-2 (IL-2) is a cytokine that exerts its actions via binding to a variety of interleukin-2 receptors (IL-2R), thereby stimulating T-cell response. Acute renal graft rejection (AR) is known to be mediated by CD8+ T-cells, through the IL-2 pathway. The aim o [....] » Read More
Impaired wound healing is a major medical specially in diabetic condition. Scientists worldwide are looking for new ways to treat wounds. Many different natural materials such as fibroin, chitosan, collagen or keratin have gained attention for their biomedical properties. In this [....] » Read More
Tendon tissue engineering is the branch of regenerative medicine that focuses on repairing, regenerating or replacing aged or damaged tendon tissue. This approach commonly makes use of various stem cells differentiated into tenocytes with the use of growth factors and biomaterial [....] » Read More
The development of three-dimensional (3D) culture systems has transformed tissue engineering by offering more physiologically relevant models compared to traditional two-dimensional (2D) cultures. Beyond their scientific contribution, 3D models represent an ethical and innovative [....] » Read More
Title : Graphene, butterfly structures, and stem cells: A revolution in surgical implants
Alexander Seifalian, Nanotechnology & Regenerative Medicine Commercialisation Centre, United Kingdom
Technological advancements have accelerated rapidly, as evidenced by everyday innovations like mobile phones. However, healthcare diagnostics, treatments, and surgical procedures have seen minimal progress over the last 50 years. Despite optimistic reports in the media and academ [....] » Read More
Title : mRNA and RNA biodistribution to brain and bones
Nagy Habib, Imperial College London, United Kingdom
The use of transferrin receptor ligand aptamer to target the brain in-vivo Widespread expression in the dellp p[arts of the brain How to target cartilage and bone for rare and acquired diseases A new approach for cell longevity.
Title : Progenitor cell mobilization and induced neutrophilia promote neovascularization and fibrinolysis in chronically ischemic tissue
Darwin Eton, Vasogenesis Inc, United States
A quarter of a century ago Granulocyte Colony Stimulating Factor (G-CSF) was used to induce progenitor cell mobilization in clinical trials so as to promote neovascularization in patients with chronic ischemia, both in the heart and in patients with chronic limb threatening ische [....] » Read More
Title : A versatile principle for creating pre-vascularized tissue in vitro for soft and hard tissue engineering
Lucie Bacakova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
Pre-vascularization of in vitro engineered tissues significantly enhances their survival and proper function after in vivo implantation and is also a prerequisite for the relevance of in vitro tissue models. We propose a relatively simple and uniform principle for the const [....] » Read More
Title : Quantum physics and cells: The evolution of life from energy
Darwin Eton, Vasogenesis Inc, United States
We now stand at the threshold of a transformative era in medicine, where cellular and molecular approaches are revolutionizing treatment of chronic diseases. To fully harness this potential, an understanding of matter at its most fundamental level is required. The subatomic realm [....] » Read More
Title : Innovative educational strategies in tissue engineering: Integrating research into higher education
Laurie Mans, Leiden University of Applied Sciences, Netherlands
The rapid advancements in tissue engineering demands an adaptive educational curriculum to prepare the next generation of professionals for impactful careers in science and innovation. At the University of Applied Sciences, we adjust our educational curriculum by integrating appl [....] » Read More
Title : Optimizing melt electrospun PLGA fibers with CuSO4 to improve endothelial cell support
Soulmaz Sarkari, University of Oldenburg, Germany
Background: Melt electrospinning is a promising solvent-free technique for fabricating microfibrous scaffolds with controlled fiber design. However, its application is limited by the poor electrical conductivity of many polymers, including poly(lactic-co-glycolic acid) (PLGA). Th [....] » Read More
Title : Bioengineering human cornea for global supply
Jingjing You, University of Sydney, Australia
The fight against corneal blindness is a significant global challenge. Impacting all age groups, corneal disease and injury represent the 3rd most common cause of blindness affecting approximately 6.2 million people worldwide. Corneal transplantation, which uses donor corneal tis [....] » Read More
Title : Interleukin 11 drives dermal fibroblast activation in mechanical stretch-mediated skin expansion
Yi Min Khoong, NHS Fife, United Kingdom
Skin expansion is a commonly used method to generate additional skin for the repair of tissue abnormalities in many circumstances, including post-traumatic scars, congenital defects, and skin defects following tumor excision. This is accomplished by inducing skin regeneration usi [....] » Read More
Title : Expression dynamics of mesenchymal stem cell markers in canine adipose-derived stromal vascular fraction during culture
Hitesh Rana, Guru Angad Dev Veterinary and Animal Sciences University, India
The stromal vascular fraction (SVF) is a heterogeneous cell population derived from adipose tissue that has gained attention for its potential in regenerative medicine. This study investigated the expression dynamics of mesenchymal stem cell (MSCs) markers, CD90, CD105, and CD44 [....] » Read More
Title : Combining old and new concepts in targeting telomerase for cancer therapy: Transient, Immediate, Complete and Combinatory Attack (TICCA)
Jaber Jamil Haj Ali, Consulting Medical Lab, State of Palestine
Telomerase can overcome replicative senescence by elongation of telomeres but is also a specific element in most cancer cells. It is expressed more vastly than any other tumor marker. Telomerase as a tumor target inducing replicative immortality can be overcome by only one other [....] » Read More
Title : Current techniques for the ex vivo perfusion of free tissue flaps systematic review and meta analysis
Serag Saleh, St Vincent’s Hospital, Australia
Background: Access to healthy living tissue in the lab has always been an essential substrate for experimentation across the breadth of medical research. Historically originally limited to live animal studies using small mammals such as rats, and subsequently more anatomically an [....] » Read More
Title : Human model for the ex vivo perfusion of free tissue using extracorporeal membrane oxygenation
Serag Saleh, St Vincent’s Hospital, Australia
Background: The Deep Inferior Epigastric Perforator (DIEP) flap is the gold standard for autologous reconstruction of the breast following mastectomy. It recruits analogous, redundant and accessible adipocutaneous tissue from the abdomen based on a reliable and consistent blood s [....] » Read More
Title : Innovative educational strategies in tissue engineering: Bridging theory & practice in higher education
Celine Van Der Valk, Leiden University of Applied Sciences, Netherlands
The rapid advancements in tissue engineering and regenerative medicine demand a comprehensive and adaptive educational approach to prepare the next generation of professionals. At Leiden University of Applied Sciences, we offer several modules that integrate state of the art scie [....] » Read More