Nagy Habib, Imperial College London, United Kingdom
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Impaired wound healing is a major medical specially in diabetic condition. Scientists worldwide are looking for new ways to treat wounds. Many different natural materials such as fibroin, chitosan, collagen or keratin have gained attention for their biomedical properties. In this [....] » Read More
Degenerative changes in intervertebral discs (IVDs) significantly alter their mechanical properties, often leading to chronic back pain and reduced spinal function. Numerical simulations, particularly finite element analyses, are invaluable for understanding how these degenerativ [....] » Read More
Background: MSCs represent a heterogenous population of cells, which can be derived either from fetal (e.g. Wharton’s Jelly from umbilical cord, placenta, etc.) or adult human sources (e.g. Bone Marrow, Adipose Tissue, etc.). Recentrly, in our laboratory were able to i [....] » Read More
In an experiment on rats, it was demonstrated that biocompatible standardized magnetite nanoparticles (ICNB) can be effectively used in MRI. It was proven that ICNB nanoparticles significantly enhance MRI imaging. The methodology for the safe intravenous administration of ICNB ex [....] » Read More
Neuropsychiatric disorders have a significant impact on global health due to their substantial effect on disability. These mental disorders typically manifest during adolescence or early adulthood, leading to severe consequences on the patient's social, emotional, and profess [....] » Read More
Background: In tissue engineering, hydrogels made from decellularized extracellular matrix (dECM) are gaining prominence because of their inherent biochemical composition and biocompatibility. They provide a platform for 3D bioprinting structures tailored to a given tissue. Hydro [....] » Read More
Title : Eliminating implants infections with nanomedicine: Human results
Thomas J Webster, Interstellar Therapeutics, United States
Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundr [....] » Read More
Title : Graphene, butterfly structures, and stem cells: A revolution in surgical implants
Alexander Seifalian, Nanotechnology & Regenerative Medicine Commercialisation Centre, London NW1 0NH, United Kingdom
Technological advancements have accelerated rapidly, as evidenced by everyday innovations like mobile phones. However, healthcare diagnostics, treatments, and surgical procedures have seen minimal progress over the last 50 years. Despite optimistic reports in the media and academ [....] » Read More
Title : Bioengineering human cornea for global supply
Jingjing You, University of Sydney, Australia
The fight against corneal blindness is a significant global challenge. Impacting all age groups, corneal disease and injury represent the 3rd most common cause of blindness affecting approximately 6.2 million people worldwide. Corneal transplantation, which uses donor corneal tis [....] » Read More
Title : Innovative educational strategies in tissue engineering: Integrating research into higher education
Laurie Mans, University of Applied Biosciences Leiden, Netherlands
The rapid advancements in tissue engineering demands an adaptive educational curriculum to prepare the next generation of professionals for impactful careers in science and innovation. At the University of Applied Sciences, we adjust our educational curriculum by integrating appl [....] » Read More
Title : A versatile principle for creating pre-vascularized tissue in vitro for soft and hard tissue engineering
Lucie Bacakova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
Pre-vascularization of in vitro engineered tissues significantly enhances their survival and proper function after in vivo implantation and is also a prerequisite for the relevance of in vitro tissue models. We propose a relatively simple and uniform principle for the const [....] » Read More
Title : Site-Specific L-DOPA Incorporation in collagen-mimicking peptides: A novel biomaterials strategy
Mor Pasi Deutschman, Ben Gurion University, Israel
Collagen, a pivotal structural protein in the extracellular matrix (ECM), plays a critical role in providing mechanical stability and supporting cell functions, making it essential for tissue engineering (TE) applications. Our work leverages synthetic biology to engineer collagen [....] » Read More
Title : Expression dynamics of mesenchymal stem cell markers in canine adipose-derived stromal vascular fraction during culture
Hitesh Rana, Guru Angad Dev Veterinary and Animal Sciences University, India
The stromal vascular fraction (SVF) is a heterogeneous cell population derived from adipose tissue that has gained attention for its potential in regenerative medicine. This study investigated the expression dynamics of mesenchymal stem cell (MSCs) markers, CD90, CD105, and CD44 [....] » Read More
Title : Development of bacterial cellulose based shape memory aerogels for biomedical applications
Ankita Sharma, IIT Delhi, India
Wound management materials are highly advanced materials that enhance health outcomes in various settings. The high cost of such materials limits their wide-spread use, particularly among under privileged population. Therefore, developing low-cost biomaterials is crucial to reduc [....] » Read More
Title : Vat-based 3D-bioprinted scaffolds from photocurable bacterial levan for osteogenesis and immunomodulation
Yusuf Olatunji Waidi, Indian Institute of Science, India
Emerging techniques of additive manufacturing, such as vat-based three-dimensional (3D) bioprinting, offer novel routes to prepare personalized scaffolds of complex geometries. However, there is a need to develop bioinks suitable for clinical translation. This study explored the [....] » Read More
Title : Differential gene expression and tumorigenicity analysis of cultured melanocyte comparing melanoma
Atefeh Shahbazi, University of Tehran, Iran (Islamic Republic of)
This study aimed to identify the optimal growth media for culturing human skin melanocytes for clinical applications and to assess their tumorigenic potential both in vitro and in vivo. Various growth media were tested to determine the most effective and safest for melanocyte cul [....] » Read More
Title : Megakaryocyte differentiation from human induced pluripotent stem cells in rat lung using 3D bioreactor
Minoo Shahidi, Allied Medical Sciences, Iran (Islamic Republic of)
Extracellular matrix plays a crucial role in the differentiation of hiPSCs into megakaryocytes. Therefore, we aimed to prepare a suitable natural acellular scaffold, and 3D bioreactor for in-vitro proliferation, and differentiation of hiPSCs into megakaryocytes. Methods: The r [....] » Read More
Title : Innovative educational strategies in tissue engineering: Bridging theory and practice in higher education
Marissa Vacher, Leiden University of Applied Sciences, Netherlands
The rapid advancements in tissue engineering and regenerative medicine demand a comprehensive and adaptive educational approach to prepare the next generation of professionals. At Leiden University of Applied Sciences, we offer several modules that integrate state?of?the?art scie [....] » Read More
Title : Innovative educational strategies in tissue engineering: Bridging theory & practice in higher education
Celine Van Der Valk, Leiden University of Applied Sciences, Netherlands
The rapid advancements in tissue engineering and regenerative medicine demand a comprehensive and adaptive educational approach to prepare the next generation of professionals. At Leiden University of Applied Sciences, we offer several modules that integrate state of the art scie [....] » Read More
Title : Lipid nanoparticle-encapsulated VEGFa siRNA facilitates cartilage formation by suppressing angiogenesis
Yi Chen, Peking Union Medical College, China
Cartilage reconstruction in plastic and reconstructive surgery is mostly realized by surgical placement of supports, such as autologous rib cartilage implantation and prosthetic material implantation in rhinoplasty and microtia, but there are problems such as limited autologous c [....] » Read More
Title : Lipid nanoparticle-assisted miR29a delivery based on core-shell nanofibers improves tendon healing by cross-regulation of the immune response and matrix remodeling
Wei Chen, Beijing Jishuitan Hospital, China
It’s well known that transfecting siRNA into recipient cells is challenging due to the high hydrophilicity, high molecular weight and anionic charge of siRNA. What’s worse, siRNA is quickly degraded and inactivated in vivo. Therefore, it is of urgent importance to dev [....] » Read More
Title : The emerging role of induced pluripotent stem cells and its derivatives in periodontal regeneration: A scoping review of preclinical studies
Lida Kheiri, Dental Research Center, Iran (Islamic Republic of)
The main goal of periodontal regenerative therapy is to regenerate fully functional tissues that can replace the deteriorated ones resulted from periodontitis and injuries. Tissue engineering methods provide promising results in periodontium reconstruction and within its developm [....] » Read More