Title : Rapid electrical impedance analysis as a cost-effective method for characterizing doped bio-composites to be used in clinical applications
Abstract:
Metal ion-modified hydroxyapatites constitute the primary inorganic matrix of bone tissue and are approved for integration into bio-composites and protective coatings for surgical implants. Zinc enhances bone metabolism, cellular proliferation, and tissue regeneration. Numerous studies have documented the successful incorporation of zinc into the hydroxyapatite crystal lattice, verifying the resulting structural and morphological changes through advanced analytical methods such as X-ray diffraction (XRD) and scanning electron microscopy (SEM). However, conventional analytical techniques remain energy-intensive, costly, and labor-demanding. To address these constraints, this study evaluates structural modifications using electrical impedance spectroscopy (EIS). Standardizing EIS parameters against zinc-induced lattice alterations provides a rapid, cost-effective screening tool to accelerate the clinical translation of Zn-doped hydroxyapatite (ZnHA).
