Cardiovascular diseases are the leading cause of human mortality with high socioeconomic burden in developing and industrialized countries because of limited cardiac cell regeneration capacity. Along with conventional modalities, the advent of cell-based therapies has revolutioni [....] » Read More
Damages to tissues with limited self-regenerative capacity, such as cartilage, require advanced regenerative strategies. One promising approach is in situ photopolymerization (direct in-wound printing) of hydrogel scaffolds, designed to guide the migration of autologous stem cell [....] » Read More
Inherited retinal dystrophies (IRD) impact millions of people and are leading causes of blindness globally. IRDs can be caused by over 300 different genetic mutations and many of the individual disorders are rare diseases with low prevalence and few treatment options. One treatme [....] » Read More
Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (Satellite Cells: SCs). Following satellite cell activation, several factors drive asymmetric cell division to generate a stem cell and a proliferative progenitor that forms new [....] » Read More
This study investigated the effects of physical factors induced by magnetite nanoparticles (specifically, constant magnetic fields and sorption activity) on microorganisms belonging to various taxonomic groups. Biomarkers included the intensity of Free Radical Lipid Peroxidation [....] » Read More
Mechanistic studies of tumor-immune interactions and preclinical evaluation of immunotherapies require in vitro models that closely recapitulate the tumor microenvironment. Although patient-derived tumor organoids preserve key structural and functional features of native tumors, [....] » Read More
Background: Wound healing is one of the most important medical issues occurring due to the injuries or diseases. Various wound dressings with advanced physio-mechanical properties have beenfabricated for this purpose. Amongthese biomaterials, self-pumping structures with their [....] » Read More
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Melanoma and squamous cell carcinoma are among the most common skin cancers worldwide, with rising incidence and significant clinical impact. To enhance the translational relevance of preclinical drug discovery, we developed high-throughput, three-dimensional (3D) bioprinted huma [....] » Read More
Despite substantial advances in scaffold chemistry, architecture, and biofunctionalization, tissue engineering systems continue to be fundamentally constrained by open-loop design paradigms in which cellular responses are assumed to be predictable and static. Such assumptions are [....] » Read More
Objective This study aimed to compare the regenerative effect of autogenous micro-dentin and nano-dentin particles on bone regeneration in rabbits’ mandibular defects. Materials & Methods: Sixty adult New Zealand rabbits were randomly divided into three groups: a contro [....] » Read More
Title : Will be updated soon...
Nagy Habib, Imperial College London, United Kingdom
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Title : AI-integrated high-throughput tissue-chip for space-based biomanufacturing applications
Kunal Mitra, Florida Tech, United States
Predicting human drug responses from animal studies remains a persistent challenge in pharmaceutical development. Despite extensive optimization of preclinical protocols, fewer than 10% of drug candidates entering clinical trials ultimately receive approval, with failures frequen [....] » Read More
Title : Will be updated soon...
Alexander Seifalian, Nanotechnology & Regenerative Medicine Commercialisation Centre, United Kingdom
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Title : The regenerative medicine of the future
Marco Polettini, DVM, Italy
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Title : Advanced 3D tissue models: Pioneering tools for investigating health and disease
Lucie Bacakova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
In vitro tissue models are laboratory-grown biological systems that use isolated cells, tissues, or organs to simulate the structure and function of living organisms. Traditional models are two-dimensional (2D) cell cultures, in which cells are grown as a monolayer on flat s [....] » Read More
Title : Personalized and Precision Medicine (PPM): A unique healthcare model via pathology-related modelling and biodesign-inspired translational applications for the next generation of human healthcare and biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
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Title : Building possibility for gangrene reversals in complex wounds by regenerative care
Sandeep Shrivastava, Datta Meghe Institute of Medical Sciences, India
Will be Updated Soon...
Title : Polysaccharide Based Nanotubes for Medical Applications
Ivan Kelnar, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Czech Republic
β-1,3-glucan polysaccharides are important biomaterials with a comb-like structure, which treat diseases and promote health in a number of important ways including antitumor, immune-stimulating activities, etc. Their well-known triple-helix conformation in water has so far b [....] » Read More
Title : A resorbable and biomimetic 3D-printed natural hydrogel scaffold driving large-volume soft tissue repair: evidence from a large animal study
Audrey Cherblanc, Healshape SAS, France
Breast cancer is the most common form of cancer in women, often requiring total mastectomy. In the US, 38% of affected women undergo this procedure (1), yet only 33% opt for reconstruction (2). Despite the availability of multiple reconstruction methods, a study conducted in the [....] » Read More
Title : An adipose-derived dECM hydrogel as a versatile ECM platform for pancreatic diseases
Lisa Martin, University Grenoble Alpes, France
Pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% of pancreatic cancers and remains one of the deadliest malignancies in the worldwide, with a 5-year survival rate of only 8–13%1–3. PDAC arises from the exocrine compartment (ductal and acinar ce [....] » Read More
Title : 3D in vitro model of Dupuytren’s disease
Jarmila Knitlova, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
Dupuytren’s disease (DD) is a common fibrotic disorder of the hand, characterized by progressive thickening and contracture of the palmar and digital fascia. Surgical excision remains the primary treatment; however, there are currently no therapies to prevent disease progre [....] » Read More
Title : Stem cell technologies to integrate biodesign related tissue engineering within the frame of cell based regenerative medicine: towards the preventive therapeutic and rehabilitative resources and benefits
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
The end-stage heart failure is a global scourge, and cardiovascular disease (CVD) is a major health problem and the leading cause of morbidity and mortality in the Globe. And thus the treatment and prevention of CVD are considered to be the public health priorities. The latter me [....] » Read More
Title : The pomegranate theory: a systematic review and meta-analysis on decellularization techniques for tissue-engineered aortic scaffolds development
Shakil M Hussain, The National MedTech Foundation, United Kingdom
Key Words: Decellularisation, Aortic grafts, Extracellular matrix (ECM), Sodium dodecyl sulfate (SDS), Sonication, High hydrostatic pressure (HHP), Biocompatibility Background: Decellularised aortic grafts are a promising alternative to synthetic and biological vascular substitut [....] » Read More
Title : Enhanced osteogenic differentiation of human mesenchymal stem cells: Impact of surface terminations of nanocrystalline diamond coatings
Shanaya Surendra Phal Desai, Institute of Physiology of the Czech Academy of Sciences, Czech Republic
The existing bone implant materials lack sufficient mechanical stability and surface properties for effective cell-material interactions, thereby limiting osseointegration. Nanocrystalline diamond (NCD) coatings are promising materials for bone biomimetics because of their compel [....] » Read More
Title : In vitro evaluation of lyophilized dedifferentiated fat cells (DFAT) impregnated artificial dermis
Kazutaka Soejima, Nihon University, School of Medicine, Japan
Dedifferentiated fat cells (DFAT) were infiltrated into an artificial dermal collagen sponge under reduced pressure, followed by lyophilization to create lyophilized DFAT-impregnated artificial dermis. In this study, the release of bioactive substances was examined in vitro. M [....] » Read More