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Cancer Pathophysiology

Pathophysiology: It is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury, simply called as a convergence of pathology with physiology. The conditions where cancer development consist of multistep process involving mutation and selection for cells with a progressively increasing capacity for proliferation, survival, invasion, and metastasis known as Cancer Pathophysiology.

Genetics: The scientific discipline that investigation of genes and pathways in cancer development. Cancer geneticists use several approaches including the analysis of the genomes of cancer patients to identify cancer genes.

Epigenetics: It is considered as rapidly growing field of cancer research which includes study of behavioural and environmental changes that affect the active genes. Mutations in the DNA sequence of specific genes led to the uncontrolled cell reproduction seen in cancer.

Metastasis: The spread of cancer cells from the place where they initially formed to another parts of the body. In metastasis, cancer cells break away from the original primary tumor, travels through the blood or lymph system, and form a new tumor in other organs or tissues of the body. The newly formed cells also represents the primary tumour. Likewise if breast cancer spreads to the lung, the cancer cells in the lung are breast cancer cells, not converted into lung cancer cells.

Metabolism:  It means the chemical changes that take place in a cell or an organism of the body. Cancer metabolism is one of the past research in cancer biology, refers to the alterations in cellular metabolism pathways that are evident in cancer cells compared with most normal tissue cells. Those Metabolic alterations in cancer cells are numerous includes-

  • Aerobic glycolysis
  • Reduced oxidative phosphorylation
  • Increased generation of biosynthetic intermediates which helps  for cell growth and proliferation

Committee Members
Speaker at International Conference on Clinical & Translational Oncology 2026 - Yan Leyfman

Yan Leyfman

NYP- Meyer Cancer Center, United States
Speaker at International Conference on Clinical & Translational Oncology 2026 - Rajvir Dahiya

Rajvir Dahiya

University of California San Francisco, United States
Speaker at International Conference on Clinical & Translational Oncology 2026 - Jianhua Luo

Jianhua Luo

University of Pittsburgh School of Medicine, United States
ICTO 2026 Speakers
Speaker at International Conference on Clinical & Translational Oncology 2026 - Pietro Salvatori

Pietro Salvatori

Formerly, Humanitas San Pio X Hospital, Italy
Speaker at International Conference on Clinical & Translational Oncology 2026 - Sergey Suchkov

Sergey Suchkov

N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Speaker at International Conference on Clinical & Translational Oncology 2026 - Shinya Tajima

Shinya Tajima

National Hospital Organization Shizuoka Medical Centre, Japan
Speaker at International Conference on Clinical & Translational Oncology 2026 - Nayara Delgado Andre

Nayara Delgado Andre

Federal University of São João del-Rei (UFSJ), Brazil

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