Organoids and 3D bioprinting have emerged as groundbreaking technologies in cancer research, offering more realistic models of human tumors. Organoids, which are miniature, three-dimensional cultures grown from patient tissue, closely mimic the complexity of tumors found in the human body, allowing researchers to study cancer behavior in a controlled environment. By testing potential drugs on organoids, researchers can identify effective treatments personalized to an individual’s cancer. 3D bioprinting enhances this approach by creating tumor models that replicate the structure and microenvironment of actual tumors, providing an even more accurate platform for testing therapies. These technologies hold great promise in improving cancer treatment and drug development.