The miracle of autologous growth factors enriched bone graft matrix (sticky bone) in regenerative endodontic micro surgery

Title : The miracle of autologous growth factors enriched bone graft matrix (sticky bone) in regenerative endodontic micro surgery

Abstract:

The use of platelet concentrates in dentistry evolves frequently, from the initial platelet-rich plasma (PRP) to sophisticated centrifugation procedures and injectable PRF preparations. Alveolar ridge augmentation, periodontal surgery, implant surgery, and endodontic regeneration are just a few of the disciplines that have used platelet concentrates for hard and soft tissue healing. 

With breakthroughs in surgical approaches, some authors have proposed the combination of platelet concentrates with bone graft materials such as synthetic bone, xenografts and allografts, a novel idea that involves creating "sticky bone," a growth factor-enriched bone graft matrix. This composite biomaterial, is a promising autologous material, results in a significant release of cytokines and autologous growth factors that responsible for healing and tissue recovery, in addition, these growth factors promotes proliferation of mesenchymal stem cells, fibroblasts, and osteoblasts, impacting the development of tissue neoformation. 

Sticky bone application in regenerative endodontic surgery in cases of through and through lesions, apico-marginal defects, and non-healed large apical lesions after root canal treatment will modulate the microenvironment in periapical defects that demand guided tissue regeneration (GTR), which combines the use of bone graft material plus a resorbable or non-resorbable membrane, and this may elicit some immunological response. So, using sticky bone after apicoectomy provides us with an autologous growth factor-enriched bone graft matrix that simplifies handling during the surgical operations due to its optimal moldability without disintegration into the surrounding soft tissues. It also allows stabilization of the bone graft in the defect to accelerate tissue healing with the elimination of graft loss and inhibits the ingrowth of soft tissue in the graft, which results in complementing the surgery and increasing the success rate. 

Keywords: platelet concentrates, injectable PRF, sticky bone, Regenerative Endodontics, micro-surgery.

Biography:

Nirvana Khalaf Mansour graduated from Cairo University in May 2009, earned her Master’s degree in Endodontics from SCU in 2016, and completed her Ph.D. in Endodontics at SCU in 2021. She is a certified member of the European Society of Endodontology (ESE) and a member of the Pierre Fauchard Academy, USA. She serves as a reviewer for the Science Publishing Group (SPG), Saudi Dental Journal (Q2 Journal), and Asian Journal of Dental Research, and is recognized as a Peer Review Excellence Graduate by IOP Publishing (2022). She is a lecturer and trainer for new batches of dentists at the Comprehensive Insurance Medical Complex / State Presidency Training Authority. As an international speaker, she has presented at the IFEA World Congress, Glasgow (2024); European Society of Endodontology Congress, Helsinki (2023); Budapest (2022); Pan Arab Endodontic Congress, Amman (2024); IADR Egyptian Section (2022 and 2023); PanEndo (2019, 2022), as well as at multiple scientific events organized by Egyptian dental syndicates. She was awarded the Best Poster Presentation Prize at the Pan Arab Endodontic Congress in Amman (2024) and at PanEndo in Cairo (2022). She is a Gold Member of the 3D Cleaning Project and serves as an administrator for Style Arabiano Endodontics. She has been a member of the scientific committees for the International Conference on Dentistry (December 2022) and the International Prosthodontic Conference, Paris (2022). To date, she has 10 publications in international journals.