Title : Graphite oxide is an efficient green catalyst and support material in organic synthesis
Abstract:
Catalyst is an important ingredient in organic synthesis. Many catalysts are known which show very good selectivity and reactivity but they are not green and sustainable. Therefore, scientists around the globe are trying to develop not only efficient but also green and sustainable catalysts. On the other hand, to avoid the agglomeration issues of nanoparticles, support materials also played a very crucial role. In both cases, carbon materials are far ahead of other type of materials. Among the various allotropes of carbon, graphite oxide (GO) occupies a supreme position because it has a large surface area with various functional groups. We exploit these properties of GO for the synthesis of various biologically, pharmaceutically, and industrially important organic molecules. Benzodiazepine and its derivatives are one of the most privileged structures in the pharmaceutical industry. It possesses a broad spectrum of activities. Mainly they are used to treat anxiety disorder. GO was utilized to synthesize 1,5- benzodiazepines and spirodibenzo[1,4]diazepines under green and sustainable conditions1,2. Palladiums are mainly used to construct carbon-carbon and carbon-heteroatom bonds. Palladium salts are costly and moreover, reusability is one of the biggest challenges. So, palladium nanoparticles was grafted on GO surface (Pd@GO) and utilized to make Carbon- Carbon bond followed by coumarin synthesis using C-H activation of aryans and alkynes3.
Audience Take Away
- Application of environment-friendly, sustainable materials in organic synthesis.
- Other researchers can also utilize graphene oxide in their research.
- This catalyst can be used at the Industrial level.