Rahul Hajare

Title : Molar characterization and analytical UPLC method development of matrix impurity, disregards impurity, specified impurity associated undetectable impurity of laboratory drug Isatin

Abstract:

This is out line work on the process development for the impurity detection of Isatin from synthetic occurring and several new methods have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. UPLC method has been developed and validated for simultaneous estimation of matrix impurity, disregards impurity; specified impurity associated undetectable impurity in pure synthetic formulations. Separation was carried out using column Hypersil ODS C18 (250 mm x 4.6mm x 5μm particle size) in isocratic mode using mobile phase composition pH 6.0 ammonium acetate Buffer: Acetonitrile (68:32) v/v and UV detection at 310 nm. The impurities were eluted at a flow rate of 1.0 mL/ min. The average retention times for matrix impurity, disregards impurity, specified impurity associated undetectable impurity were 2.86 and 3.67 min, 4.54 min respectively. The method was validated according to the ICH guidelines.

Biography:

Dr. Rahul Hajare studied Pharmaceutical Chemistry at the Amravati University, India and graduated as B.Pharm in 2002. He then joined the research group of Institute of Pharmaceutical Research and Education and Quality Assurance, Nagpur University. He received his PhD degree in 2012 at the Vinayaka Mission University. After two year postdoctoral fellowship supervised by Renowned and Scientist Respected Dr. Ramesh Paranjape at the National AIDS Research Institute ICMR Pune India. He obtained the position of an Associate Professor at the G H Raisoni University Amravati GHRU.He has published more than 70 research articles in SCI (E) journals.).Dr. Rahul Hajare is awarded by Scholar Hindu University of America.