Wei Zhang

Title : Recent developments in one-pot stepwise synthesis

Abstract:

One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less amount of waste disposal. Among three kinds of one-pot syntheses 1) cascade reactions, 2) multicomponent reactions (MCRs), and 3) one-pot stepwise synthesis (OPSS), OPSS could be more flexible and practical since it is carried out stepwisely and have variable reaction conditions for different steps. This presentation highlights the recent development in OPSS involving cyclization, cycloaddition, rearrangement, and catalytic reactions for the synthesis of heterocyclic scaffolds, asymmetric molecules, natural products, and bioactive compounds.

Audience Take Away

• Understand three different kinds of one-pot synthesis
• Learn green chemistry benefit of one-pot synthesis
• Aware of OPSS in organic synthesis and catalysis

Biography:

Dr. Wei Zhang is a Professor and the Director of the Center for Green Chemistry at the University of Massachusetts Boston. He received his PhD and did his post-doctoral research at the University of Pittsburgh.  His previous positions include Research Assistant Professor at the University of Pittsburgh, Senior Chemist at DuPont, and Director at Fluorous Technologies, Inc. Prof. Zhang’s research is in the areas of fluorous chemistry, organocatalysis, medicinal chemistry, and green chemistry. He has coauthored over 240 papers including three in Chem. Rev., 6 US patents, and two books on green synthesis. He received the International Fluorous Technology Award in 2015.