Title : Real-time monitoring for diabetes management
Abstract:
Diabetes is a global health challenge, with most cases being type 2 diabetes. Notably, type 2 diabetes can often be detected at an early phase through real-time monitoring of metabolic biomarkers. To address the challenge, a wearable wristband has been developed that integrates microneedles capable of detecting three key biomarkers, along with ultrasound sensors for continuous monitoring of vital signs. The device is aimed at advanced diabetes management and early risk detection of diabetes-related complications.
In this study, we monitored healthy individuals and detected subjects who have a high risk for developing diabetes, demonstrating the capability of the devices to differentiate metabolic profiles across populations. We developed a high-accuracy microneedle system using advanced nanofabrication techniques to ensure reliable and sensitive detection of the biomarkers. The microneedles feature a flexible, replaceable design, making them appropriate for next-generation closed-loop systems.
The key biomarkers include glucose, lactate, and alcohol, which are monitored simultaneously with vital signs such as blood pressure and heart rate. The multimodal sensing approach enables a comprehensive understanding of how metabolic parameters and vital signs respond to daily activities. Despite advances in wearable technologies, real-time, minimally invasive detection of biochemical markers and vital signs remains a significant challenge. This integrated microneedle-ultrasound platform offers a promising technology to bridge the gap in current diabetes monitoring systems.
