Agnieszka Ewa Wiacek

Title : Immunosuppressive cyclosporine CsA. The physicochemical characterization of liposomal and colloidal systems.

Abstract:

These researches present an overview of the possibilities of testing various cyclosporine (CsA) formulations with an emphasis on parameters that may be key to improving the stability and biocompatibility. The feasibility of immunosuppressive cyclosporine CsA 

The chosen CsA systems were developed using dipalmitoylphosphocholine (DPPC) and/or cholesterol as a lipid matrix, stabilized with ethanol, with soybean oil or n-tetradecane as oil phase in emulsions, under natural pH, room and physiological temperature 

Their integrity was found to be strictly dependent on the stabilizers. The highest CsA penetrability with the system containing phospholipid in the context of its interactions with lipid membranes was shown. Also, the bioavailability of CsA can be enhanced with the biopolymer antibacterial chitosan. The obtained results showed the suitability of liposome/microemulsion as promising vehicles for CsA delivery, the most hopeful to be formulation with the smaller particle size facilitating absorption. However, when safety is assessed, relying on just the particle size cannot be the only criteria. Reassumed, the CsA formulation stability known on the basis of the size and zeta potential measurements guarantees a decrease of the individual variations in the drug bioavailability, toxicity and minimizes rejection.

Biography:

Prof. Agnieszka Ewa Wiącek studied chemistry in 1989-1994 at Maria Curie-Skłodowska University in Lublin (Poland) and in 1994 was employed as a research assistant in the Department of Physical Chemistry. She received D. Sc. degree in chemistry in September 2000 on the base of PhD thesis including the effect of natural stabilizers on oil/water emulsion stability. In 2013 she received Dr. habilitation degree in physical chemistry writing dissertation titled “Effect of the selected biologically-active substances, mainly phospholipids and (phospho)lipases on the interfacial properties of dispersed systems” and in 2018 associate professor position. She published about 90 scientific papers (including 15 monoauthor’s paper) which were cited according to GoogleScholar about 1700 times. Additionally she is author or co-author of about 100 conference' presentations. In 1997-2004 she was an examiner of Recruitment Commission of Chemistry Faculty in Lublin and outer cities. She was promoter of more than 50 master of science thesis (M. Sc) or licentiate thesis (B. Sc.) and 2 doctoral thesis. She participated in 6 scientific projects including international projects.