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2nd Edition of International Conference on Tissue Engineering and Regenerative Medicine

September 16-17, 2022 | Paris, France

September 16 -17, 2022 | Paris, France
TERMC 2021

Immunosuppressive cyclosporine CsA. The physicochemical characterization of liposomal and colloidal systems.

Agnieszka Ewa Wiacek, Speaker at Speaker for Tissue Engineering Conference - Agnieszka Ewa Wiacek
Maria Curie-Sklodowska University, Poland
Title : Immunosuppressive cyclosporine CsA. The physicochemical characterization of liposomal and colloidal systems.

Abstract:

These researches present an overview of the possibilities of testing various cyclosporine (CsA) formulations with an emphasis on parameters that may be key to improving the stability and biocompatibility. The feasibility of immunosuppressive cyclosporine CsA 

The chosen CsA systems were developed using dipalmitoylphosphocholine (DPPC) and/or cholesterol as a lipid matrix, stabilized with ethanol, with soybean oil or n-tetradecane as oil phase in emulsions, under natural pH, room and physiological temperature 

Their integrity was found to be strictly dependent on the stabilizers. The highest CsA penetrability with the system containing phospholipid in the context of its interactions with lipid membranes was shown. Also, the bioavailability of CsA can be enhanced with the biopolymer antibacterial chitosan. The obtained results showed the suitability of liposome/microemulsion as promising vehicles for CsA delivery, the most hopeful to be formulation with the smaller particle size facilitating absorption. However, when safety is assessed, relying on just the particle size cannot be the only criteria. Reassumed, the CsA formulation stability known on the basis of the size and zeta potential measurements guarantees a decrease of the individual variations in the drug bioavailability, toxicity and minimizes rejection.

Biography:

Dr Hab. Agnieszka Ewa Wiacek studied chemistry in 1989-1994 at Maria Curie-Sklodowska University and in 1994 was employed as a research assistant in the Department of Physical Chemistry. She received D. Sc. degree in chemistry in September 2000 on the base of PhD. thesis including the effect of natural stabilizers on oil/water emulsion stability. In 2013 she received Dr. habilitation degree in physical chemistry writing dissertation titled “Effect of the selected biologically-active substances, mainly phospholipids and (phospho)lipases on the interfacial properties of dispersed systems”. She has published more than  80 research articles which were cited according to Scopus more than 650 times. Additionally she is author or co-author of 100 conference' articles. She is promoter of about 27 master of science thesis (M. Sc) and 25 licentiate thesis (B. Sc.) and 2 doctoral thesis. She participated in 6 scientific projects. In 2018 she obtained the position of an Associate Professor at MCSU.

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