2nd Edition of International Conference on Tissue Engineering and Regenerative Medicine

September 16-17, 2022 (Online Event)

September 16 -17, 2022 | Online Event
TERMC 2021

Multiphysics/Multiscale Modeling and Simulation of Organic Retinal Prostheses

Riccardo Sacco, Speaker at Tissue Engineering Congress
Politecnico di Milano, Italy
Title : Multiphysics/Multiscale Modeling and Simulation of Organic Retinal Prostheses

Abstract:

In this talk we propose a model for the simulation of retinal prostheses based on the use  of organic polymer nanoparticles (NP). The model consists of a nonlinearly coupled system of partial differential equations accounting for: (1) light photoconversion into free charge carriers in the NP bulk; (2) charge transport in the NP bulk due to drift and diffusion forces; (3) net charge recombination in the NP bulk due to the balance between light absorption and particle-particle recombination; (4) electron-driven molecular oxygen reduction and capacitive coupling at the NP-solution interface; (5) ion electrodiffusion in the solution bulk; (6) capacitive and conductive coupling across the neuronal membrane. The proposed model is solved in stationary conditions and in one spatial dimension. System coupling is dealt with a modification of the Gummel Decoupled algorithm conventionally used in inorganic semiconductor simulation. System discretization is conducted using the Finite Element Method, with stabilization terms to prevent spurious unphysical oscillations in the electric potential and ensure positivity of carrier and ion concentrations. Model predictions suggest that the combined effect of NP polarization and resistivity of the NP-neuron interface results in neuron depolarization and supports the efficacy of organic NPs in retinal prosthesis development.

Biography:

Dr. Sacco received a MS in Electronic Engineering from Politecnico di Milano (PoliMi), Italy in 1989, and a PhD in Applied Mathematics from Universita’ degli Studi di Milano, Italy in 1992. In 1995, Dr. Sacco obtained the position of Assistant Professor in Numerical Analysis (NA) at PoliMi, in 2001 the position of Associate Professor in NA at PoliMi and in 2017 the National Habilitation to the role of Full Professor in NA. Dr. Sacco has published 6 books and more than 80 research articles in SCI(E) journals.

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