Platelet rich plasma(PRP) therapy is one of the fast pacing branch of regenerative medicine in intervention dermatology and trichology. This has significantly changed the out of difficult to treat difficult disorders in addition to contributing immensely in the field of cosmetic-intervention dermatology and trichology. PRP therapy can be used as an adjuvant in various cocktail treatments of scarring alopecia, androgenetic alopecia, alopecia areata in trichology with promising results. It has also proved its mettle as an add on therapy in hair transplant and randomized controlled trials are published to prove its efficacy in reducing the catagen fall, preserving the transplanted hair and giving faster results as early as 6 months against 9 months in control group. It also helps in activating native dormant hair thus adding on to existing density. It can be used in difficult conditions like surgical treatment of vitiligo with LAPEEST (laser ablation of recipient area with PRP enriched epidermal suspension) and yielding impressive pigmentation as early as 3 to 6 months. The triple combination of ablative laser, PRP therapy and epidermal fragment suspension works in multipronged way to give fast and cosmetically acceptable pigmentation. Other indications are burn scars, post acne and post traumatic scars where it is an excellent adjuvant to ablative lasers and microneedling radiofrequency to resurface not only skin, but underlying appendages as well, thus restoring near normal looking skin. PRP therapy when utilized to aid in the healing process can yield unparalleled results in various difficult areas in intervention dermatology and trichology.