Title : Tissue engineering in periodontal therapy - a case Series
Abstract:
Periodontitis is a globally prevalent inflammatory disease characterized by periodontal tissue destruction. The main purpose of periodontal treatment is to arrest the progression of the disease and to regenerate the lost periodontal structures. Periodontal regenerative therapy is aimed at reconstruction of lost or injured tissues through tissue engineering with the application of barrier membrane (guided tissue regeneration), osseous defects and growth factors.
One of the oldest biomaterial used as a scaffold is foetal membrane. The foetal membrane which consists of aminion (AM) and chorion membrane as a bilayer are used individually with novel technique in periodontics. Growth factors play critical roles in periodontal repair through the regulation of cell behavior such as cell adhesion, migration, proliferation and differentiation. Different growth factors have specific functions and target cells in wound healing, and their delicate balance is required for optimal tissue repair. Human bone allografts are predominantly used in clinical practice for the treatment of periodontal defects as they give predictable results and eliminate an additional donor site surgery
The presentation includes the studies which involves the clinical application of allografts, ACM membranes (as barrier membrane in guided tissue regeneration) and PRP-PRF (growth factors) in periodontal therapy.
