2nd Edition of International Conference on Tissue Engineering and Regenerative Medicine

September 16-17, 2022 (Online Event)

September 16 -17, 2022 | Online Event
TERM C 2022

Design of 3D bioengineered personalized scaffolds to potentiate bone ingrowth and angiogenic network for oral tissues reconstruction

Christiane Salgado , Speaker at TERM C conferences 2022
Institute of Research and Innovation in Health(i3S), Brazil
Title : Design of 3D bioengineered personalized scaffolds to potentiate bone ingrowth and angiogenic network for oral tissues reconstruction


Population ageing (>70 years) and associated risk factors (alcohol addiction and smoke - 85%) increase the number of oral cancer (more frequently, head and neck squamous cell carcinoma - HNSCC) cases requiring large bone defects repair, raising the need for bone and oral mucosa regenerative solutions. The development of novel approaches to treat maxillofacial bone defects deriving from tumor removal will require a customized architecture, bioactive and responsive properties. The development of innovative bone grafts shall foster patient-specific therapeutic solution, that will stimulate angiogenesis and bone regeneration, while avoiding patient-tumor regrowth. A biomimetic hybrid system will deliver chemical and biological clues for a critical bone defect repair and overcome current limitations related with mechanic and biological performance. Here, the bone complex void-space will be filled with a cellular approach device derived from dental tissues, providing an ideal 3D microenvironment to foster the formation of vascularized bone tissue throughout the bioengineered scaffold. The personalized biomimetic materials will be radically more efficient approach to treat large maxillofacial defects and offer new hope to patients with oral cancer, condition that affect circa of 8.9M patients/year with a treatment overall cost of 100M€/year. This breakthrough technology will positive impact on patients' prognosis, reducing post-operative problems and recovery time while enhancing their life quality.


Dr. Christiane Salgado is dedicated to the biomaterials and regenerative research field. She is currently an Assistant researcher at INEB/i3S. She has a background of Dental Medicine (Brazil) and a PhD in Mechanical Engineering (Materials and Process) at State University of Campinas (Brazil) in 2009. By using tissue engineering strategies, she aims at providing an in situ required biological signals to promote vascular and bone tissue regeneration at critical bone defects that includes the development of new polymers for efficient cells/cell products delivery. She has also been engaged in technology transfer projects including the development of a bone graft at Portugal. To this date, she published 19 papers in peer reviewed international journals and 1 book chapters with more than 370 citations (h index = 10), 2 patents and 3 awards.