HYBRID EVENT: You can participate in person at London, UK or Virtually from your home or work.

5th Edition of International Conference on Tissue Engineering and Regenerative Medicine

September 18-20 | London, UK

September 18 -20, 2025 | London, UK
TERMC 2022

Placental therapy: Is really a natural weapon for wound healing therapy?

Madhu Gupta, Speaker at Tissue Engineering Conferences
School of Pharmaceutical Sciences, India
Title : Placental therapy: Is really a natural weapon for wound healing therapy?

Abstract:

Placental extract formulation Regenerin (Patent no- RU 2469704 CI, dt: 07.07.2011) has been reported to possess antioxidant, antimicrobial, anti-inflammatory, cellular proliferation, and tissue regeneration properties. Considering the properties of placental extract, the present investigation was undertaken to investigate the effectiveness of this formulation in rat diabetic foot ulcer (DFU). Diabetes was induced by intraperitoneal (i.p) injection of 65 mg/kg of Streptozotocin (STZ) in rats and open excision wounds were produced in feet by using scalpel. The formulations were topically applied to all the groups once a day till the complete healing was achieved. Blood glucose monitoring, body weight, food and water content, parameters were measured weekly. Wound healing was assessed by analyzing % wound closure,wound area measurements, hydroxyproline content, epithelialization period, and inflammatory marker CRP At the end of study, foot was excised for histopathology and hydroxyproline level. Treatment with Regenerin gel produced decrease in wound size and increased epithelization from 8th day which continued until 18 days when complete closure was found. Regenerin-gel showed the higher hydroxyproline content, decrease in inflammatory markers, neovascularization as well as increases the collagen deposition. It can be concluded from this study that topically applied regernerin-gel may be a potential approach for faster wound healing for treatment of chronic diabetic wounds.

Biography:

Dr. Madhu Gupta is working as an Associate Professor in Delhi Pharmaceutical Sciences and Research University, New Delhi. She is pioneer scientist in the field of nanotechnology and drug delivery field. Dr. Madhu Gupta has research experience pertaining to drug delivery to nanoformulations for placental extract, regenerative medicine, magical molecule delivery, bioligands for targeting of bioactives and drug moiety, biopolymers, She is exploring the area of fungal infection, wound healing , diagnostic devices, PK-PD modelling, herbal delivery and psoriasis. Dr. Gupta recognized among the top 2% of scientists globally in the year 2023-24, list that often comes from data compiled by Stanford University researchers, published in collaboration with Elsevier and other academic databases. She has over 100 research publications to her credit published in journals of high scientific impact and contributed 30 chapters in various renowned books and to several international and national books.

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