HYBRID EVENT: You can participate in person at London, UK or Virtually from your home or work.

3rd Edition of International Conference on Tissue Engineering and Regenerative Medicine

August 21-23, 2023

August 21 -23, 2023 | London, UK
TERM C 2022

Madhu Gupta

Madhu Gupta, Speaker at TERM C 2022 Conferences
Research University, India
Title : Placental therapy: Is really a natural weapon for wound healing therapy?

Abstract:

Placental extract formulation Regenerin (Patent no- RU 2469704 CI, dt: 07.07.2011) has been reported to possess antioxidant, antimicrobial, anti-inflammatory, cellular proliferation, and tissue regeneration properties. Considering the properties of placental extract, the present investigation was undertaken to investigate the effectiveness of this formulation in rat diabetic foot ulcer (DFU). Diabetes was induced by intraperitoneal (i.p) injection of 65 mg/kg of Streptozotocin (STZ) in rats and open excision wounds were produced in feet by using scalpel. The formulations were topically applied to all the groups once a day till the complete healing was achieved. Blood glucose monitoring, body weight, food and water content, parameters were measured weekly. Wound healing was assessed by analyzing % wound closure,wound area measurements, hydroxyproline content, epithelialization period, and inflammatory marker CRP At the end of study, foot was excised for histopathology and hydroxyproline level. Treatment with Regenerin gel produced decrease in wound size and increased epithelization from 8th day which continued until 18 days when complete closure was found. Regenerin-gel showed the higher hydroxyproline content, decrease in inflammatory markers, neovascularization as well as increases the collagen deposition. It can be concluded from this study that topically applied regernerin-gel may be a potential approach for faster wound healing for treatment of chronic diabetic wounds.

Biography:

Dr. Madhu Gupta is working as an Associate Professor in Delhi Pharmaceutical Science and Research University, New Delhi. She has research experience pertaining to drug delivery to nanoformulations for magical molecule delivery, bioligands for targeting of bioactives and drug moiety, biopolymers, cancer nanomedicine as well as topical delivery. She has over 80 research publications to her credit published in journals of high scientific impact and contributed 30 chapters in various renowned books with h index 20 and more than 1000 citations.. She has the recipient of Research Excellence of the Year 2020, Youth Education Icon of the Year 2018, Young Scientist Award, Best Administrative Service Award, IDMA-G.P. Nair award and Prof. C.S. Chauhan award, BioAsia Innovation Award – 2012, Grace India awards. She has also filed the PCT patent for effective wound healing therapy.

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