Title : Cellular conflict, degenerative disease onset, and nutritional demands: A novel insight into the role of single-cell nutrients as an adjuvant to cell therapy
Abstract:
As the incidence of degenerative disease increases with age, we argue that conditions are related to nutritional defects in a particular organ. As not all genetic risk factors trigger diseases in old age, other factors likely intervene. Many recent studies have revealed nutritional status deficiency without providing a holistic rationale for interpreting such derangements. Alternatively, many disease markers reflect a state of imbalanced metabolite levels that respond to nutritional therapy. A variety of diseases, including osteoporosis, MS, Alzheimer’s disease, ALS, diabetic ulcers, and cancers, will be reviewed as examples of a particular deficiency status triggering an organ degeneration tendency. Organ functions, metabolism, and activities are under dynamic conditions depending on numerous extrinsic and intrinsic factors, such as stress, nutrient availability, environment, and genetics. Therefore, the dietary requirements of a particular organ are changeable according to the demands of interplay among various circumstances. Which organ could meet its optimum needs is dependent on its biochemical, physiological and activity potential. Under conditions of inadequate nutritional resources, the most “endowed” cells and/or organs will receive the right amount of nutrients leaving other cells and /or organs in deficit state that demands a change in metabolic status of this organ to compensate for a deficit in the food supply. This food shortage can affect signalling, energy, structural, or defence mechanisms in cells, leading to an unbalanced state. Moreover, if an organ experiences an increase in food demand as a result of an unprecedented stressful condition without being able to meet it optimally from the body nutrient pool, this will necessitate a way of “getting rid” of some cells. This could be conceptualized as a type of organ conflict, and even cells fight over finite nutrients. If such defects can be corrected by supplying the right nutrients to the right site at the right time, many degenerative diseases can be prevented. Notably, natural products contain growth factors, functional food ingredients, and nutrients. They can restore the balanced state of the cells and protect them. Additionally, one benefit of stem cell therapy might be its ability to provide a cellular microenvironment with the necessary elements needed to maintain a balanced cell internal environment. To the best of our knowledge, this study provides novel insights into the interpretation of degenerative processes. In conclusion, single-cell nutritional status warrants further research. We also look forward to adding adjuvant nutrients to potentiate cell therapy, which may greatly enhance the process of organ regeneration via extending stem cell longevity of the transplanted cells. Daily nutritional requirements can be modified to meet the daily nutritional requirements of different organs based on real-time needs. A detailed map outlining the tailored nutritional needs of various types of cells must be built.
Audience Take Away:
- This proposal may guide people to take care of their different organs based on good acquaintance with their various nutritional needs in order to avoid old age diseases and maintain health.
- Everyone activity may affect a particular cell and/or organ, which necessitates a particular diet measure to counteract any unwanted effects triggered by this specific type of activity on a particular organ.
- This may provide new insights into the importance of lifestyle and types of targeted diet to avoid degenerative diseases. The care of body organs turns out to be an art and science.
- Diseases. Care of body organs turns out to be an art and science.
