Title : Molecular mechanism of GATA2 and AR regulating BRCA1 transcription in sporadic ovarian cancer
Abstract:
Ovarian cancer is one of the malignancies of the female reproductive system. Due to the lack of clinical symptoms in the early stage, it is very important to study the mechanism of the occurrence and development of ovarian cancer at the molecular level for early diagnosis and prognosis of this disease. BRCA1 is an important tumor suppressor gene. The ovarian cancer patients with this gene mutation have a poor prognosis. Although the relationship between BRCA1 mutation and ovarian cancer has been studied thoroughly, it is difficult to explain the mechanism of sporadic ovarian cancer with very low mutation frequency. The reduction of its expression may be another key factor, which is closely related to the transcriptional regulation of BRCA1 gene by transcription factors. By far, the knowledge about this aspect is still relatively scarce. GATA binging protein 2 (GATA2), a member of the zinc finger transcription factor GATA family, has been proved to be closely related to the occurrence and development of ovarian cancer. Androgen receptor (AR) is a nuclear transcription factor. In addition to playing an important role in male growth and development, it is also closely related to ovarian cancer and is functionally related to GATA2. What is the relationship between the three genes in ovarian cancer? This research analyzed the regulatory effects of GATA2 and AR on BRCA1 from the perspective of transcriptional regulation, and clarified the influence of this regulatory mechanism on the malignant biological behavior of ovarian cancer. The results provide a theoretical basis for further revealing the molecular regulation mechanism of BRCA1 in ovarian cancer, and lay the foundation for the further development of new potential targets for ovarian cancer.
Audience Take Away:
- You can learn knowledge about the transcriptional regulation research
- You can know effect of reduced expression of BRCA1 gene on ovarian cancer
- You can learn about the link between transcription factors GATA2 and AR in ovarian cancer
- You can use the idea of this research to explore whether reduced BRCA1 expression in other cancer species affects the biological behavior of cancer cells
