Title : "Preparing the soil"-optimizing metabolic management in regenerative medicine procedures
Abstract:
Background:
Osteoarthritis (OA) is a degenerative disease linked to metabolic syndrome and chronic inflammation. Studies show that metabolic management is important in regenerative medicine treatments for degenerative diseases, including OA. The connection between metabolic syndrome, inflammation, and osteoarthritis is explored, with a focus on the importance of lifestyle habits in managing metabolic syndrome risk factors and protecting the subchondral bone to prevent OA progression.
Objectives:
This article aims to explore the role of metabolic management in regenerative treatments for osteoarthritis. It discusses the importance of pre-treatment evaluation and complementary exams and the impact of diet and the gut microbiome on bone and cartilage health. The article also explores drug strategies for treating OA and the role of hormones in tendinopathies.
Methods:
This article is a literature review of studies exploring the connection between metabolic syndrome, inflammation, and degenerative diseases like OA. It provides an overview of the role of lifestyle habits, complementary exams, diet, gut microbiome, drug strategies, and hormones in managing OA.
Results:
Complementary exams provide important data for physicians to choose the appropriate therapeutic modality. The importance of diet in bone and cartilage health is emphasized, with studies showing the effects of high fat and high sugar diets and the benefits of a Mediterranean-style diet. The gut microbiome plays a key role in bone health, and nutritional supplements with prebiotics and probiotics can positively affect skeletal health. Drug strategies for treating OA, including antiresorptive, bone anabolic, and antihypertensive drugs, have shown potential benefits in protecting bone and cartilage. Hormones, including insulin, sex hormones, growth hormones, and thyroid hormones, also play an important role in bone and cartilage health.?
Conclusions:
Metabolic management is important in regenerative medicine treatments for degenerative diseases, including OA. The gut microbiome and its metabolites, drug strategies, and hormones play a key role in bone and cartilage health. Complementary exams, lifestyle habits, and diet are important factors in managing metabolic syndrome risk factors and preventing OA progression. Further research is needed to explore the connection between metabolic management and regenerative treatments for OA.
