Title : Simultaneous 3D bioprinting of multilayer tissues, blood vessels and organs
Abstract:
The rapid development of 3D bioprinting technologies is important for tissue engineering, regenerative medicine and drug evaluation. Designed a Roll Porous Scaffold (RPS) technology describes the ways to overcome the main imperfection of extrusion-based bioprinting and 2D “body on a chip” systems. The proposed technology is thousands of times superior to the analogues in terms of multi functionality. RPS offers methods for fast volume bioprinting of multilayer tissues with blood vessels and organs providing a physiologically relevant 3D environment without the lack of only planar cell-cell interactions. The use of multiple inkjet heads and a winding from roll to roll scaffold allows the formation of complex multi-cell structures with high density and precision. Seiko Epson Corporation introduces next-generation piezoelectric printing technology PrecisionCore suitable for bio-inks. The print head plate has 800 nozzles (two rows of 400 nozzles), each of which is approximately 20 microns in diameter and capable of passing droplets up to 1.5 picoliter (1.5×10-12 liter). The potential of RPS in a spatially mediated microenvironment and controlled micron density of living cells and intercellular distance due to ribbon scaffolds consisting of biomaterials such as nanofibers, sponge. These thin tape scaffolds ensure that the cell droplets of the next layer do not leak from the calculated locations. RPS presents major features of novel multifunctional 3D bioprinting suitable for forming of human tissues (own print head for each kind of cells and collagen hydrogel) according to digital model. New techniques can be used to improve the organ tissue biomodel and test new drugs on it.
Audience Take Away:
- The novel 3D bio printing technology is thousands of times superior to the dominant analogues
- New methods are suitable for formation of multilayer tissues, blood vessels and organs at the same time for its repair, transplantation
- Solution for the problem of the lack of only planar intercellular interactions in multilayer tissues, nerves, bones and entire organ
- A potential accelerator for the development of complex “body on a chip” systems
- Improvement for the biomodel of organ tissue and testing of new drugs on it
