Title : Potential of articular cartilage resident progenitor in the field of cartilage regeneration
Abstract:
Our research goal is to characterize cartilage-derived progenitors, isolate a purer population of cells with enhanced chondrogenic potential, and apply this knowledge towards the evolution of improved therapeutics for the regeneration of genuine hyaline-like cartilage. In the field of cartilage tissue engineering and regenerative medicine, there is still a requirement to enhance biological and functional outcomes, in terms of improving ongoing treatment and developing new therapeutic strategies. Our research focuses on the creation and validation of osteoarthritic models in animals, characterization of cartilage-derived progenitors, and assessing their potential implications for cartilage regeneration using in-vitro and in-vivo conditions in comparison to commonly employed cells named bone marrow derived MSCs and chondrocytes.We hypothesize that a better understanding of these progenitors, in comparison to other cell types, will enable us to create a detailed biological profile and develop better approaches towards the treatment of cartilage pathologies. Ultimately, the overarching goal of our research is to establish translational studies that leverage cell isolates from cartilage to facilitate effective cartilage repair.
Audience Take Away Notes
- The standardized methodology for the isolation of cartilage resident cells: chondroprogenitors and chondrocytes
- The comparative chondrogenic potential of chondrogenitors to commonly employed cells in the field of cartilage repair
- The upcoming advances in the field using articular cartilage derived chondroprogenitors
