Sergey Suchkov

Title : The promising future of the unique translational tool to manage cardiac self renewal and regeneration to secure the post infarction period

Abstract:

The approaches securing cardiac regeneration in post-infarction period are not available to be practiced. The key problem is the identity of cells be born to generate functionally active cardiac myocytes replenishing those being lost during ischemia. With identification of resident cardiac stem cells (CSCs), it has been supposed that the latter may be a crucial source to initiate and prompt myocardial self-renewal and regeneration. In the last years, the focus has been moved towards a concept of the new wave of cardiac myocyte (CM) formation via a scenario of dedifferentiation and proliferation of mature CMs. The observation that CSCs can be developed inside a pool of immature cardiac cells by formation of “cell-in-cell structures” (CICSs) has enabled us to conclude that CICSs being encapsulated are implicated into mammalian cardiac myogenesis over the entire lifespan. It had been demonstrated before that new CMs are generated through formation of CSC-derived transitory amplifying cells (TACs) either in the CM colonies or in a process of intracellular development of CICSs being encapsulated. The analysis of adult rat cardiac cell suspension 1-5, 10, and 14 days after permanent coronary occlusion and ischemia/reperfusion has gifted a researcher a unique phenomenon of TAC release from mature CMs with clear sarcomeric structure. In this case a development of the intracellular CSC occurs within the vacuole pre-formed by CSC-driven sarcolemma-induced invagination. 

Biography:

Sergey Suchkov was born in the City of Astrakhan, Russia, in a family of dynasty medical doctors. In 1980, graduated from Astrakhan State Medical University and was awarded with MD. In 1985, Suchkov maintained his PhD as a PhD student of the I.M. Sechenov Moscow Medical Academy and Institute of Medical Enzymology. In 2001, Suchkov maintained his Doctor Degree at the National Institute of Immunology, Russia. From 1989 through 1995, Dr Suchkov was being a Head of the Lab of Clinical Immunology, Helmholtz Eye Research Institute in Moscow. From 1995 through 2004 - a Chair of the Dept for Clinical Immunology, Moscow Clinical Research Institute (MONIKI). In 1993-1996, Dr Suchkov was a Secretary-in-Chief of the Editorial Board, Biomedical Science, an international journal published jointly by the USSR Academy of Sciences and the Royal Society of Chemistry, UK.