Title : 3D printable/injectable personalized amyloidgenic hydrogel for accelerated wound healing and tissue regeneration
Abstract:
Personalized biomaterials with multifunctional healing capabilities are essential for addressing complex and diverse tissue injuries. In this work, we present a novel 3D printable and injectable amyloidogenic hydrogel, derived from self-assembling protein fibrils, designed to accelerate healing in renal abscesses, internal organ injuries, deep muscle wounds, and burn wounds. The hydrogel mimics the Extracellular Matrix (ECM), forming a biocompatible, structurally stable scaffold that supports cell survival, proliferation, and migration. Unlike conventional hydrogels limited by weak mechanical properties, high cost, and poor reproducibility, our hybrid formulation offers enhanced mechanical resilience, scaffold stability, and cost-effectiveness while maintaining high biodegradability and biocompatibility. Tuneable porosity and adhesive properties further support cellular infiltration and integration. Inherent antimicrobial, antioxidant, and anti-inflammatory properties facilitate faster tissue regeneration through neovascularization and collagen remodeling. The dual-mode delivery injectable for internal applications like kidney abscesses and printable for surface wounds ensures versatility and site- specific adaptation. In vivo studies on rat models confirm the hydrogel’s effectiveness in reducing inflammation, enhancing tissue integration, and significantly accelerating healing outcomes in both soft and complex tissues. This personalized, ECM-inspired hydrogel system addresses current limitations in tissue engineering and wound management, offering a promising, patient-adaptable solution for acute and chronic injuries. It represents a transformative platform in regenerative medicine, capable of meeting the multifaceted demands of modern wound care through its multifunctional healing capabilities.
