Title : Complete Blood Count (CBC) & immuno-inflammatory dysfunction in patients with behavioral disorders associated with psychosis
Abstract:
Neuropsychiatric disorders have a significant impact on global health due to their substantial effect on disability. These mental disorders typically manifest during adolescence or early adulthood, leading to severe consequences on the patient's social, emotional, and professional life. Schizophrenia is a chronic and severe psychotic disorder that affects approximately 1% of the population. It is characterized by positive symptoms such as delusions and hallucinations, negative symptoms such as depression and social withdrawal, as well as cognitive dysfunction. Over the past ten years, research has highlighted the role of inflammation in patients with schizophrenia. However, this has not yet led to effective new treatments. The limited results of clinical trials on anti-inflammatory drugs may reflect the inability of available medications to target the appropriate inflammatory mechanisms. Therefore, it is necessary to develop approaches to identify the right targets for new therapies. To strengthen the hypothesis of the involvement of neuroinflammation in schizophrenia, we investigated the implication of neutrophils, basophils, lymphocytes, red blood cells(RBG), hemoglobin levels (HGB), hematocrit HCT), platelets, red blood cell hemoglobin content (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), mean platelet volume (MPV), and platelet distribution width (PDW) in the complete blood count (CBC) of patients with schizophrenia compared to healthy individuals. Our study was conducted on 387 individuals, consisting of 280 men and 107 women, including 155 healthy individuals and 232 individuals with schizophrenia. Our results showed a significant increase in neutrophils, lymphocytes, eosinophils, basophils, HGB, HCT, MCH, and MCHC. We also detected a significant decrease in RBG and PDW, along with a slight increase and a trend toward significance in monocyte levels and MPV. To better understand this phenomenon, it is necessary to include a larger number of individuals with schizophrenia as well as healthy controls, using big data and artificial intelligence in the field of healthcare.
Keywords: schizophrenia, inflammation, , neutrophils, platelets, lymphocytes, CBC, RDW, HCT MCH MCHC, PDW, MPV.
