Scientific Program

Abstract:

Nano magnetite copper (I) complexes are exceptionally antibacterial, anticancer, anti-inflammatory, and antimicrobial capabilities, which have drawn particular attention as a potential class of medicinal medicines. Nano-magnetic copper complexes [Nano-magnetite-Lys@Cu(PPh3)I] and [Nano-magnetite-Arg@Cu(PPh3)I] with sizes of 12 nm and 15 nm are reported to have undergone a multi-step synthesis and characterization process. Complexes significantly outperformed the conventional medicine cis-platin (IC50=88.91 g/mL) in terms of their ability to inhibit the growth of MCF-7 breast cancer cells, with IC50 values of 104.38 g/mL and 95.81 g/mL, respectively. Both complexes' hyperthermia investigations produced impressive specific absorption rate (SAR) values of 36.83-85.81 W/g and 97.67-125.58 W/g, respectively, at therapeutic temperatures of 48 °C and 43 °C. According to the studies, the combined effects of hyperthermia and chemotherapy can make both complexes a double-edged sword in the treatment of breast cancer. Additionally, they have minimal toxicity, are inexpensive, and quickly undergo redox reactions, which enable a range of ligands to combine to produce stable and biologically effective complexes.

Audience Take Away Notes:

• Audience will learn in vitro anticancer activity of nano-magnetite
• The significant anticancer activities of complexes are attributed to synergistic effect of nano-magnetite supported ligand architecture and Cu metal. this research is useful for evaluating the potential of nano-magnetite for biomedical applications
• The studies reveal that complexes play dual role (anticancer/hyperthermia) against breast cancer cells and can be further explored as a double edged sword for their potent applications in breast cancer therapeutics

Biography:

Dr. Tarulata N. Chhowala is at present serving as an Associate Professor, Coordinator of M.Sc Evening Course at Department of Chemistry and also serving as Coordinator of Day care centre in Veer Narmad South Gujarat University, Surat, Gujarat. She did her M.Sc in Inorganic Chemistry and she was awarded Ph.D by the same University in 2010. She has several research papers to her credit and attended National and International conferences in countries like China and Mauritius. Her research interest are in the field of Green Chemistry, Material Science, Organic Synthesis - Dyes, Drugs, Polymer, Catalysis and Liquid Crystal. Dr. Tarulata N. Chhowala is at present serving as an Associate Professor, Coordinator of M.Sc Evening Course at Department of Chemistry and also serving as Coordinator of Day care centre in Veer Narmad South Gujarat University, Surat, Gujarat. She did her M.Sc in Inorganic Chemistry and she was awarded Ph.D. by the same University in 2010. She has several research papers to her credit and attended National and International conferences in countries like China and Mauritius. Her research interest are in the field of Green Chemistry, Material Science, Organic Synthesis Dyes, Drugs, Polymer, Catalysis and Liquid Crystal.